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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 29 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL16B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL18A, RPL18B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL1A, RPL1B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • RNA processing
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL24A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL9A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS2
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • RPS22A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • telomere maintenance
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 4.1857E-35 29 101 22 6292
    cytosolic part 4.109E-33 29 122 22 6292
    ribosomal subunit 5.7972E-29 29 183 22 6292
    cytosolic large ribosomal subunit 3.2921E-26 29 60 16 6292
    cytosol 1.3256E-24 29 284 22 6292
    ribosome 2.123E-24 29 290 22 6292
    ribonucleoprotein complex 6.4221E-24 29 514 25 6292
    large ribosomal subunit 1.392E-21 29 110 16 6292
    non-membrane-bounded organelle 4.5908E-13 29 959 22 6292
    intracellular non-membrane-bounded organelle 4.5908E-13 29 959 22 6292
    macromolecular complex 1.5559E-11 29 1635 25 6292
    cytosolic small ribosomal subunit 1.3793E-8 29 38 6 6292
    small ribosomal subunit 7.6167E-7 29 73 6 6292
    organelle part 1.5629E-5 29 2282 22 6292
    intracellular organelle part 1.5629E-5 29 2282 22 6292
    90S preribosome 5.7332E-5 29 17 3 6292
    cytoplasmic part 7.1901E-5 29 2482 22 6292
    preribosome 4.7862E-4 29 34 3 6292
    cytoplasm 6.3629E-4 29 3552 25 6292
    small nucleolar ribonucleoprotein complex 4.2414E-3 29 72 3 6292
    stress granule 4.609E-3 29 1 1 6292
    intracellular part 7.8434E-3 29 4938 28 6292
    intracellular 9.4454E-3 29 4975 28 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 5.703E-34 29 376 28 6292
    cellular macromolecule biosynthetic process 7.4562E-22 29 1187 29 6292
    macromolecule biosynthetic process 7.8338E-22 29 1189 29 6292
    cellular protein metabolic process 5.7548E-21 29 1074 28 6292
    gene expression 7.2997E-21 29 1283 29 6292
    protein metabolic process 2.7926E-20 29 1136 28 6292
    cellular biosynthetic process 2.5526E-18 29 1567 29 6292
    biosynthetic process 4.8717E-18 29 1602 29 6292
    cellular macromolecule metabolic process 1.561E-13 29 2285 29 6292
    macromolecule metabolic process 3.4949E-13 29 2349 29 6292
    regulation of translation 1.8531E-12 29 57 9 6292
    posttranscriptional regulation of gene expression 3.5311E-12 29 61 9 6292
    regulation of cellular protein metabolic process 9.8336E-12 29 68 9 6292
    regulation of protein metabolic process 2.1676E-11 29 74 9 6292
    primary metabolic process 1.5641E-10 29 2896 29 6292
    cellular metabolic process 6.0142E-10 29 3033 29 6292
    metabolic process 1.9326E-9 29 3157 29 6292
    ribosomal subunit assembly 1.3729E-7 29 55 6 6292
    ribosome assembly 3.4512E-7 29 64 6 6292
    organelle assembly 5.4319E-7 29 69 6 6292
    ribonucleoprotein complex assembly 3.0047E-6 29 92 6 6292
    ribosome biogenesis 1.5562E-5 29 346 9 6292
    regulation of gene expression 1.6672E-5 29 445 10 6292
    regulation of macromolecule biosynthetic process 2.0665E-5 29 456 10 6292
    regulation of cellular biosynthetic process 2.7942E-5 29 472 10 6292
    regulation of biosynthetic process 2.8462E-5 29 473 10 6292
    ribonucleoprotein complex biogenesis 2.9063E-5 29 374 9 6292
    ribosomal large subunit assembly 3.2768E-5 29 41 4 6292
    cellular process 3.6108E-5 29 4426 29 6292
    regulation of macromolecule metabolic process 3.7337E-5 29 488 10 6292
    regulation of primary metabolic process 5.8427E-5 29 514 10 6292
    regulation of cellular metabolic process 8.3597E-5 29 536 10 6292
    regulation of metabolic process 9.934E-5 29 547 10 6292
    cellular macromolecular complex assembly 1.4713E-4 29 182 6 6292
    ribosomal large subunit biogenesis 2.0295E-4 29 65 4 6292
    ribosomal small subunit biogenesis 2.1318E-4 29 26 3 6292
    regulation of translational fidelity 7.2384E-4 29 9 2 6292
    cellular macromolecular complex subunit organization 9.8024E-4 29 259 6 6292
    biological regulation 1.4786E-3 29 1213 13 6292
    macromolecular complex assembly 1.497E-3 29 281 6 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.5505E-3 29 13 2 6292
    regulation of translational elongation 1.5505E-3 29 13 2 6292
    ribosomal small subunit assembly 1.8037E-3 29 14 2 6292
    regulation of cellular process 2.0652E-3 29 796 10 6292
    maturation of SSU-rRNA 2.4067E-3 29 59 3 6292
    rRNA processing 2.6167E-3 29 128 4 6292
    regulation of biological process 2.6857E-3 29 824 10 6292
    cellular component biogenesis 2.994E-3 29 694 9 6292
    rRNA metabolic process 3.3475E-3 29 137 4 6292
    response to cycloalkane 4.609E-3 29 1 1 6292
    response to organic cyclic substance 4.609E-3 29 1 1 6292
    negative regulation of mRNA processing 4.609E-3 29 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 4.609E-3 29 1 1 6292
    negative regulation of RNA splicing 4.609E-3 29 1 1 6292
    response to cycloheximide 4.609E-3 29 1 1 6292
    macromolecular complex subunit organization 4.9914E-3 29 357 6 6292
    cellular component assembly 7.1986E-3 29 385 6 6292
    translational elongation 7.7104E-3 29 29 2 6292
    regulation of mRNA processing 9.1975E-3 29 2 1 6292
    regulation of RNA splicing 9.1975E-3 29 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 9.1975E-3 29 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 2.7363E-41 29 212 28 6292
    structural molecule activity 2.8105E-35 29 339 28 6292
    RNA binding 2.4991E-5 29 367 9 6292
    nucleic acid binding 2.2487E-3 29 666 9 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle