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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 23 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
NHP6A
  • nuclear chromatin
  • chromatin remodeling
  • chromatin organization
  • positive regulation of transcription from RNA polymerase II promoter
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase II promoter
  • chromatin binding
  • PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS22A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • telomere maintenance
  • translation
  • structural constituent of ribosome
  • RPS23B, RPS23A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • ribosome
  • intracellular
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 7.1591E-27 23 101 17 6292
    cytosolic part 2.2548E-25 23 122 17 6292
    ribosomal subunit 3.1397E-22 23 183 17 6292
    cytosol 6.6296E-19 23 284 17 6292
    ribosome 9.5031E-19 23 290 17 6292
    ribonucleoprotein complex 4.5383E-16 23 514 18 6292
    cytosolic large ribosomal subunit 2.9495E-15 23 60 10 6292
    large ribosomal subunit 1.6683E-12 23 110 10 6292
    non-membrane-bounded organelle 2.6903E-11 23 959 18 6292
    intracellular non-membrane-bounded organelle 2.6903E-11 23 959 18 6292
    cytosolic small ribosomal subunit 3.7394E-11 23 38 7 6292
    small ribosomal subunit 4.4635E-9 23 73 7 6292
    macromolecular complex 2.2652E-7 23 1635 18 6292
    90S preribosome 2.8067E-5 23 17 3 6292
    organelle part 4.726E-5 23 2282 18 6292
    intracellular organelle part 4.726E-5 23 2282 18 6292
    preribosome 2.3718E-4 23 34 3 6292
    cytoplasmic part 8.3315E-4 23 2482 17 6292
    cytoplasm 1.8805E-3 23 3552 20 6292
    stress granule 3.6554E-3 23 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 2.671E-24 23 376 21 6292
    cellular macromolecule biosynthetic process 1.8389E-17 23 1187 23 6292
    macromolecule biosynthetic process 1.9122E-17 23 1189 23 6292
    gene expression 1.1179E-16 23 1283 23 6292
    cellular protein metabolic process 1.1402E-14 23 1074 21 6292
    cellular biosynthetic process 1.1521E-14 23 1567 23 6292
    biosynthetic process 1.9216E-14 23 1602 23 6292
    protein metabolic process 3.662E-14 23 1136 21 6292
    cellular macromolecule metabolic process 7.1036E-11 23 2285 23 6292
    macromolecule metabolic process 1.345E-10 23 2349 23 6292
    primary metabolic process 1.6931E-8 23 2896 23 6292
    cellular metabolic process 4.9214E-8 23 3033 23 6292
    metabolic process 1.241E-7 23 3157 23 6292
    ribosomal subunit assembly 1.2658E-6 23 55 5 6292
    regulation of translation 1.5163E-6 23 57 5 6292
    ribosome biogenesis 1.7052E-6 23 346 9 6292
    posttranscriptional regulation of gene expression 2.1338E-6 23 61 5 6292
    ribosome assembly 2.7151E-6 23 64 5 6292
    ribonucleoprotein complex biogenesis 3.2649E-6 23 374 9 6292
    regulation of cellular protein metabolic process 3.6766E-6 23 68 5 6292
    organelle assembly 3.9543E-6 23 69 5 6292
    regulation of protein metabolic process 5.6004E-6 23 74 5 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.1918E-5 23 13 3 6292
    ribonucleoprotein complex assembly 1.6374E-5 23 92 5 6292
    maturation of SSU-rRNA 5.4067E-5 23 59 4 6292
    rRNA processing 8.0783E-5 23 128 5 6292
    ribosomal small subunit biogenesis 1.0504E-4 23 26 3 6292
    rRNA metabolic process 1.1162E-4 23 137 5 6292
    cellular process 3.0112E-4 23 4426 23 6292
    ribosomal large subunit assembly 4.1551E-4 23 41 3 6292
    cellular macromolecular complex assembly 4.2202E-4 23 182 5 6292
    cellular component biogenesis 4.4858E-4 23 694 9 6292
    regulation of gene expression 7.644E-4 23 445 7 6292
    regulation of macromolecule biosynthetic process 8.8492E-4 23 456 7 6292
    ncRNA processing 9.0415E-4 23 215 5 6292
    regulation of cellular biosynthetic process 1.0869E-3 23 472 7 6292
    regulation of biosynthetic process 1.1006E-3 23 473 7 6292
    ribosomal small subunit assembly 1.1326E-3 23 14 2 6292
    regulation of macromolecule metabolic process 1.3241E-3 23 488 7 6292
    ribosomal large subunit biogenesis 1.6079E-3 23 65 3 6292
    regulation of primary metabolic process 1.7955E-3 23 514 7 6292
    ncRNA metabolic process 2.0084E-3 23 257 5 6292
    cellular macromolecular complex subunit organization 2.0783E-3 23 259 5 6292
    regulation of cellular metabolic process 2.2902E-3 23 536 7 6292
    regulation of metabolic process 2.5747E-3 23 547 7 6292
    macromolecular complex assembly 2.9709E-3 23 281 5 6292
    response to cycloalkane 3.6554E-3 23 1 1 6292
    response to organic cyclic substance 3.6554E-3 23 1 1 6292
    negative regulation of mRNA processing 3.6554E-3 23 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 3.6554E-3 23 1 1 6292
    negative regulation of RNA splicing 3.6554E-3 23 1 1 6292
    response to cycloheximide 3.6554E-3 23 1 1 6292
    biological regulation 6.7486E-3 23 1213 10 6292
    regulation of mRNA processing 7.2981E-3 23 2 1 6292
    regulation of RNA splicing 7.2981E-3 23 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 7.2981E-3 23 2 1 6292
    macromolecular complex subunit organization 8.2356E-3 23 357 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 1.061E-29 23 212 21 6292
    structural molecule activity 2.881E-25 23 339 21 6292
    RNA binding 9.2348E-3 23 367 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle