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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 28 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL16B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL18A, RPL18B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL1A, RPL1B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • RNA processing
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL24A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS1A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS2
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 2.4869E-33 28 101 21 6292
    cytosolic part 1.9338E-31 28 122 21 6292
    ribosomal subunit 1.7012E-27 28 183 21 6292
    cytosolic large ribosomal subunit 2.5296E-24 28 60 15 6292
    cytosol 2.3967E-23 28 284 21 6292
    ribosome 3.753E-23 28 290 21 6292
    ribonucleoprotein complex 7.0814E-23 28 514 24 6292
    large ribosomal subunit 5.0685E-20 28 110 15 6292
    non-membrane-bounded organelle 2.3317E-12 28 959 21 6292
    intracellular non-membrane-bounded organelle 2.3317E-12 28 959 21 6292
    macromolecular complex 5.2268E-11 28 1635 24 6292
    cytosolic small ribosomal subunit 1.0987E-8 28 38 6 6292
    small ribosomal subunit 6.0964E-7 28 73 6 6292
    90S preribosome 7.178E-7 28 17 4 6292
    preribosome 1.3278E-5 28 34 4 6292
    organelle part 3.3136E-5 28 2282 21 6292
    intracellular organelle part 3.3136E-5 28 2282 21 6292
    cytoplasmic part 1.4025E-4 28 2482 21 6292
    cytoplasm 9.8232E-4 28 3552 24 6292
    small nucleolar ribonucleoprotein complex 3.8338E-3 28 72 3 6292
    stress granule 4.4501E-3 28 1 1 6292
    intracellular part 9.6979E-3 28 4938 27 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 9.8838E-33 28 376 27 6292
    cellular macromolecule biosynthetic process 4.0298E-21 28 1187 28 6292
    macromolecule biosynthetic process 4.2266E-21 28 1189 28 6292
    cellular protein metabolic process 3.3251E-20 28 1074 27 6292
    gene expression 3.6435E-20 28 1283 28 6292
    protein metabolic process 1.5234E-19 28 1136 27 6292
    cellular biosynthetic process 1.039E-17 28 1567 28 6292
    biosynthetic process 1.9388E-17 28 1602 28 6292
    cellular macromolecule metabolic process 4.3324E-13 28 2285 28 6292
    macromolecule metabolic process 9.4321E-13 28 2349 28 6292
    regulation of translation 1.2869E-12 28 57 9 6292
    posttranscriptional regulation of gene expression 2.4536E-12 28 61 9 6292
    regulation of cellular protein metabolic process 6.8397E-12 28 68 9 6292
    regulation of protein metabolic process 1.5089E-11 28 74 9 6292
    primary metabolic process 3.4162E-10 28 2896 28 6292
    cellular metabolic process 1.2537E-9 28 3033 28 6292
    metabolic process 3.8688E-9 28 3157 28 6292
    ribosomal subunit assembly 1.0962E-7 28 55 6 6292
    ribosome assembly 2.759E-7 28 64 6 6292
    organelle assembly 4.3453E-7 28 69 6 6292
    ribonucleoprotein complex assembly 2.4112E-6 28 92 6 6292
    ribosome biogenesis 1.1272E-5 28 346 9 6292
    regulation of gene expression 1.165E-5 28 445 10 6292
    regulation of macromolecule biosynthetic process 1.4465E-5 28 456 10 6292
    regulation of cellular biosynthetic process 1.9605E-5 28 472 10 6292
    regulation of biosynthetic process 1.9974E-5 28 473 10 6292
    ribonucleoprotein complex biogenesis 2.1139E-5 28 374 9 6292
    regulation of macromolecule metabolic process 2.6261E-5 28 488 10 6292
    ribosomal large subunit assembly 2.8381E-5 28 41 4 6292
    regulation of primary metabolic process 4.1257E-5 28 514 10 6292
    cellular process 5.1428E-5 28 4426 28 6292
    regulation of cellular metabolic process 5.9229E-5 28 536 10 6292
    regulation of metabolic process 7.05E-5 28 547 10 6292
    cellular macromolecular complex assembly 1.1953E-4 28 182 6 6292
    ribosomal large subunit biogenesis 1.7631E-4 28 65 4 6292
    ribosomal small subunit biogenesis 1.9165E-4 28 26 3 6292
    regulation of translational fidelity 6.7442E-4 28 9 2 6292
    cellular macromolecular complex subunit organization 8.0479E-4 28 259 6 6292
    macromolecular complex assembly 1.2328E-3 28 281 6 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.4452E-3 28 13 2 6292
    regulation of translational elongation 1.4452E-3 28 13 2 6292
    regulation of cellular process 1.5228E-3 28 796 10 6292
    ribosomal small subunit assembly 1.6815E-3 28 14 2 6292
    regulation of biological process 1.989E-3 28 824 10 6292
    maturation of SSU-rRNA 2.1721E-3 28 59 3 6292
    cellular component biogenesis 2.2841E-3 28 694 9 6292
    rRNA processing 2.2914E-3 28 128 4 6292
    rRNA metabolic process 2.9347E-3 28 137 4 6292
    biological regulation 3.5468E-3 28 1213 12 6292
    macromolecular complex subunit organization 4.153E-3 28 357 6 6292
    response to cycloalkane 4.4501E-3 28 1 1 6292
    response to organic cyclic substance 4.4501E-3 28 1 1 6292
    negative regulation of mRNA processing 4.4501E-3 28 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 4.4501E-3 28 1 1 6292
    negative regulation of RNA splicing 4.4501E-3 28 1 1 6292
    response to cycloheximide 4.4501E-3 28 1 1 6292
    cellular component assembly 6.0122E-3 28 385 6 6292
    translational elongation 7.1991E-3 28 29 2 6292
    regulation of mRNA processing 8.8811E-3 28 2 1 6292
    regulation of RNA splicing 8.8811E-3 28 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 8.8811E-3 28 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 8.9458E-40 28 212 27 6292
    structural molecule activity 5.4485E-34 28 339 27 6292
    RNA binding 1.8158E-5 28 367 9 6292
    nucleic acid binding 1.7083E-3 28 666 9 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle