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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 19 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DBP9
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 4.3E-29 19 211 19 6292
    nuclear lumen 1.3629E-22 19 453 19 6292
    organelle lumen 1.9614E-19 19 660 19 6292
    intracellular organelle lumen 1.9614E-19 19 660 19 6292
    membrane-enclosed lumen 6.0905E-19 19 700 19 6292
    non-membrane-bounded organelle 2.5789E-16 19 959 19 6292
    intracellular non-membrane-bounded organelle 2.5789E-16 19 959 19 6292
    nuclear part 3.7675E-15 19 1103 19 6292
    nucleus 4.8456E-10 19 2041 19 6292
    intracellular organelle part 4.0756E-9 19 2282 19 6292
    organelle part 4.0756E-9 19 2282 19 6292
    preribosome, large subunit precursor 1.9392E-6 19 9 3 6292
    Noc1p-Noc2p complex 8.6401E-6 19 2 2 6292
    membrane-bounded organelle 5.8584E-5 19 3771 19 6292
    intracellular membrane-bounded organelle 5.8584E-5 19 3771 19 6292
    Noc complex 8.5935E-5 19 5 2 6292
    nuclear outer membrane 1.0783E-4 19 86 4 6292
    preribosome 1.317E-4 19 34 3 6292
    nuclear membrane 1.7227E-4 19 97 4 6292
    nuclear envelope 2.4367E-4 19 199 5 6292
    intracellular organelle 2.5052E-4 19 4070 19 6292
    organelle 2.517E-4 19 4071 19 6292
    90S preribosome 1.1437E-3 19 17 2 6292
    outer membrane 1.7203E-3 19 178 4 6292
    organelle outer membrane 1.7203E-3 19 178 4 6292
    nuclear membrane-endoplasmic reticulum network 4.5093E-3 19 232 4 6292
    endomembrane system 5.4792E-3 19 398 5 6292
    Noc2p-Noc3p complex 6.0308E-3 19 2 1 6292
    nucleolar part 7.9168E-3 19 45 2 6292
    intracellular part 9.9367E-3 19 4938 19 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 7.2228E-25 19 346 19 6292
    ribonucleoprotein complex biogenesis 3.292E-24 19 374 19 6292
    ribosomal large subunit biogenesis 2.4157E-20 19 65 12 6292
    cellular component biogenesis 5.1604E-19 19 694 19 6292
    ribosome assembly 3.6847E-10 19 64 7 6292
    organelle assembly 6.3458E-10 19 69 7 6292
    ribosomal large subunit assembly 1.3334E-9 19 41 6 6292
    ribonucleoprotein complex assembly 4.9567E-9 19 92 7 6292
    ribosomal subunit assembly 8.3852E-9 19 55 6 6292
    rRNA processing 5.0323E-8 19 128 7 6292
    rRNA metabolic process 8.0639E-8 19 137 7 6292
    cellular macromolecular complex assembly 5.6713E-7 19 182 7 6292
    ncRNA processing 1.7524E-6 19 215 7 6292
    ncRNA metabolic process 5.7788E-6 19 257 7 6292
    cellular macromolecular complex subunit organization 6.084E-6 19 259 7 6292
    macromolecular complex assembly 1.0432E-5 19 281 7 6292
    macromolecular complex subunit organization 4.965E-5 19 357 7 6292
    RNA processing 7.4111E-5 19 380 7 6292
    cellular component assembly 8.0565E-5 19 385 7 6292
    cellular process 1.2366E-3 19 4426 19 6292
    establishment of ribosome localization 2.6892E-3 19 26 2 6292
    ribosome localization 2.6892E-3 19 26 2 6292
    ribosomal subunit export from nucleus 2.6892E-3 19 26 2 6292
    RNA metabolic process 4.3105E-3 19 954 8 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 1.1619E-6 19 28 4 6292
    RNA-dependent ATPase activity 1.3452E-6 19 29 4 6292
    RNA helicase activity 6.1837E-6 19 42 4 6292
    ATP-dependent helicase activity 1.0627E-5 19 48 4 6292
    purine NTP-dependent helicase activity 1.0627E-5 19 48 4 6292
    helicase activity 9.3851E-5 19 83 4 6292
    ATPase activity, coupled 8.8722E-4 19 149 4 6292
    rRNA binding 1.011E-3 19 16 2 6292
    nucleoside-triphosphatase activity 2.4E-3 19 329 5 6292
    ATPase activity 3.2045E-3 19 211 4 6292
    hydrolase activity, acting on acid anhydrides 3.2669E-3 19 353 5 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 3.2669E-3 19 353 5 6292
    pyrophosphatase activity 3.2669E-3 19 353 5 6292
    RNA binding 3.8677E-3 19 367 5 6292
    5S rRNA binding 6.0308E-3 19 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle