Protein Overview: ATP4

General Information:
Name(s) found:	ATP4 / YPL078C [SGD]
Description(s) found: Found 22 descriptions. SHOW ALL	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [SGD]
Organism:	Saccharomyces cerevisiae
Length:	244 amino acids
Gene Ontology:
Cellular Component:	mitochondrial proton-transporting ATP synthase, stator stalk [ISS] mitochondrion [IDA]
Biological Process:	ATP synthesis coupled proton transport [IMP][ISS]
Molecular Function:	hydrogen ion transporting ATP synthase activity, rotational mechanism [IMP ][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMSMGVRGL ALRSVSKTLF SQGVRCPSMV IGARYMSSTP EKQTDPKAKA NSIINAIPGN  60
   61 NILTKTGVLG TSAAAVIYAI SNELYVINDE SILLLTFLGF TGLVAKYLAP AYKDFADARM 120
  121 KKVSDVLNAS RNKHVEAVKD RIDSVSQLQN VAETTKVLFD VSKETVELES EAFELKQKVE 180
  181 LAHEAKAVLD SWVRYEASLR QLEQRQLAKS VISRVQSELG NPKFQEKVLQ QSISEIEQLL 240
  241 SKLK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2 ATP20 ATP3 ATP4 ATP5 ATP6 ATP7 ATP8 INH1 OLI1 TIM11
View Details	Ho Y, et al. (2002)		ABP1 ACO1 AIM41 ATP4 BUD14 CAR2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 GAS1 GCN1 GCN3 GPH1 HHF1, HHF2 HRR25 HSP104 HXT7 HYP2 IPP1 LOC1 LOS1 LSP1 LTV1 MDH1 MDS3 MGE1 NSA1 NUG1 OYE2 PEX19 PIL1 PIN4 POL5 PTC4 PUF3 RIO2 RPC19 RPM2 RPT3 RVB1 SAP185 SAP190 SAS10 SEC2 SEC23 SEC7 SES1 SFB3 SGM1 SIT4 TMA19 TSR1 UBA1 UBC6 UTP20 VMA4 YBR225W YER138C YKU70 YPT1
View Details	Qiu et al. (2008)		ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2 ATP20 ATP3 ATP4 ATP5 ATP6 ATP7 ATP8 COB COR1 COX1 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYT1 INH1 MCR1 OLI1 QCR2 QCR6 QCR7 QCR8 QCR9 RIP1 STF1 STF2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	ATP4	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ATP4	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..89]	MSA	2.020997	View MSA. Confident ab initio structure predictions are available.
2	View Details	[90..244]	MSA	28.049997	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
hydrogen ion transmembrane transporter activity	9.75824095339252	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	8.02996687028513	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	7.03421298777104	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	6.33533983608004	bayes_pls_golite062009
cation transmembrane transporter activity	3.43905785379115	bayes_pls_golite062009
ion transmembrane transporter activity	3.40493178308083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.11087315592201	bayes_pls_golite062009
transporter activity	2.33132024466294	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	2.14184902122852	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.91129736413093	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.68240669590269	bayes_pls_golite062009
pyrophosphatase activity	1.61544861060476	bayes_pls_golite062009
ATPase activity	1.60552572277149	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.5982352071671	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.5958855657846	bayes_pls_golite062009
transmembrane transporter activity	1.51271412556287	bayes_pls_golite062009
substrate-specific transporter activity	1.35431931487507	bayes_pls_golite062009
binding	1.24770939036016	bayes_pls_golite062009
primary active transmembrane transporter activity	0.907643434530535	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.90151467619641	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.873541340643087	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.870099443464063	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.870012300409237	bayes_pls_golite062009
active transmembrane transporter activity	0.869408183980935	bayes_pls_golite062009
catalytic activity	0.67288476528593	bayes_pls_golite062009
hydrolase activity	0.636687378087875	bayes_pls_golite062009
protein binding	0.438049027037998	bayes_pls_golite062009
ATPase activity, coupled	0.423824294580682	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2