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Protein Overview: EGD1

General Information:
Name(s) found: EGD1 / YPL037C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 157 amino acids

    Gene Ontology:
    Cellular Component: nascent polypeptide-associated complex [IDALink to PubMed article]
    Biological Process: 'de novo' cotranslational protein folding [IPILink to PubMed article]
    Molecular Function: unfolded protein binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIDQEKLAK LQKLSANNKV GGTRRKLNKK AGSSAGANKD DTKLQSQLAK LHAVTIDNVA  60
   61 EANFFKDDGK VMHFNKVGVQ VAAQHNTSVF YGLPQEKNLQ DLFPGIISQL GPEAIQALSQ 120
  121 LAAQMEKHEA KAPADAEKKD EAIPELVEGQ TFDADVE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) EGD1 EGD2
    View Details (MIPS) Mewes HW, et al. (2004) EGD1 EGD2
    View Details Krogan NJ, et al. (2006) BTT1 CAF130 EGD1 EGD2 PLC1 YJR011C
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 AFR1 AHP1 ARC1 ARF1 ATP3 CAR2 CCT5 CDC33 CKA1 CKB1 CKB2 CLU1 COF1 COR1 CPR1 CYR1 CYS4 DBP2 DUN1 EGD1 ENP2 ERB1 ERG13 ERG6 FPR1 FPR3 FRS2 GCD11 GND1 GND2 GRX1 GUS1 HAS1 HEF3 HHF1, HHF2 HHT1, HHT2 HOT1 HTA1 HTB2 KRE33 KRI1 LRO1 LSP1 MET6 MGM101 NAP1 NMD3 NOG1 NOP12 NOP2 NOP4 NOP56 NTF2 NUG1 OLA1 OYE2 PDI1 PFK1 PIL1 POB3 PRM2 PRP19 PUF6 PWP1 QCR2 RNR2 RSN1 SAH1 SCP160 SEC53 SEN15 SES1 SNU13 SOD1 SPT16 SSF1 TCP1 TEF4 THS1 TIF1, TIF2 TIF6 TMA19 TSA2 UBA1 VMA4 VMA5 WTM1 YER084W YJU2 YNK1
    View Details Qiu et al. (2008) BTT1 EGD1 EGD2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LSM12 EGD1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data EGD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..157] Pfam 27.920819 NAC domain No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle