YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes:	This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Hrt1. The topolgies of protein complexes in this experiment are unknown.
Complex Size:	27 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ADR1	nucleus	regulation of carbohydrate metabolic process transcription peroxisome organization negative regulation of transcription from RNA polymerase II promoter by glucose	transcription factor activity
BBC1	actin cortical patch	actin cytoskeleton organization	myosin I binding
CDC39	nucleus cytoplasm CCR4-NOT core complex	negative regulation of transcription from RNA polymerase II promoter response to pheromone involved in conjugation with cellular fusion pseudohyphal growth nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity
CDC53	SCF ubiquitin ligase complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination during ubiquitin-dependent protein catabolic process	DNA replication origin binding ubiquitin-protein ligase activity protein binding, bridging
CRM1	nucleus	mRNA export from nucleus ribosomal large subunit export from nucleus protein export from nucleus	protein transmembrane transporter activity
DUR1,2	cytoplasm	urea metabolic process allantoin catabolic process	allophanate hydrolase activity urea carboxylase activity
ECM29	nucleus cytoplasm proteasome complex	protein catabolic process	protein binding
ECM33	fungal-type cell wall mitochondrion plasma membrane	cellular cell wall organization	molecular_function
FAA4	lipid particle cytoplasm	lipid transport lipid metabolic process N-terminal protein myristoylation	long-chain fatty acid-CoA ligase activity
GAL3	cytoplasm	galactose metabolic process positive regulation of transcription by galactose	transcription activator activity
GCN1	mitochondrion cytosol	regulation of translational elongation	molecular_function
HRT1	nucleus nuclear ubiquitin ligase complex cytoplasm SCF ubiquitin ligase complex Cul3-RING ubiquitin ligase complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination during ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity
HYP2	cytoplasm mitochondrion ribosome	translational initiation	translation initiation factor activity protein binding
MDN1	nucleus mitochondrion nucleoplasm	protein complex assembly rRNA processing ribosomal large subunit assembly	ATPase activity
MKT1	polysome cytoplasm	interspecies interaction between organisms positive regulation of translation	nuclease activity
MMS1	cellular_component	DNA repair negative regulation of transposition, DNA-mediated	molecular_function
MYO2	incipient cellular bud site cellular bud tip cellular bud neck fungal-type vacuole membrane myosin V complex mating projection tip vesicle filamentous actin	mitochondrion inheritance vacuole inheritance establishment of mitotic spindle orientation unidimensional cell growth vesicle-mediated transport Golgi inheritance vesicle transport along actin filament peroxisome inheritance membrane addition at site of cytokinesis budding cell apical bud growth	actin filament binding calmodulin binding microfilament motor activity
PFK1	6-phosphofructokinase complex cytoplasm mitochondrion	glycolysis	6-phosphofructokinase activity
PMA2	mitochondrion plasma membrane	proton transport regulation of pH	hydrogen-exporting ATPase activity, phosphorylative mechanism
RPA190	DNA-directed RNA polymerase I complex	transcription from RNA polymerase I promoter	DNA-directed RNA polymerase activity
RPN1	nucleus proteasome regulatory particle, base subcomplex cytoplasm endoplasmic reticulum	ubiquitin-dependent protein catabolic process	endopeptidase activity protein binding, bridging
TPS1	cytoplasm alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	carbohydrate metabolic process response to drug trehalose biosynthetic process response to stress	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
UBI4	cytoplasm	protein deubiquitination ascospore formation protein polyubiquitination protein monoubiquitination response to stress protein ubiquitination	protein tag ATP-dependent protein binding
VPS13	endosome mitochondrion extrinsic to membrane	ascospore formation protein retention in Golgi apparatus late endosome to vacuole transport vacuolar protein catabolic process	molecular_function
YAR009C	retrotransposon nucleocapsid	transposition, RNA-mediated	DNA-directed DNA polymerase activity RNA-directed DNA polymerase activity RNA binding protein binding ribonuclease activity peptidase activity
YGP1	fungal-type cell wall	response to nutrient response to stress	molecular_function
YLR035C-A	retrotransposon nucleocapsid	transposition, RNA-mediated	RNA binding protein binding

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
SCF ubiquitin ligase complex	9.5242E-4	27	11	2	6292
cullin-RING ubiquitin ligase complex	1.5634E-3	27	14	2	6292
6-phosphofructokinase complex	8.5646E-3	27	2	1	6292
myosin V complex	8.5646E-3	27	2	1	6292
filamentous actin	8.5646E-3	27	2	1	6292
unconventional myosin complex	8.5646E-3	27	2	1	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
response to nutrient	3.803E-5	27	16	3	6292
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	3.6753E-4	27	7	2	6292
response to extracellular stimulus	5.3794E-4	27	38	3	6292
response to nutrient levels	5.3794E-4	27	38	3	6292
response to external stimulus	5.3794E-4	27	38	3	6292
catabolic process	8.16E-4	27	496	8	6292
protein ubiquitination during ubiquitin-dependent protein catabolic process	9.5242E-4	27	11	2	6292
protein catabolic process	1.0928E-3	27	189	5	6292
macromolecule catabolic process	1.2731E-3	27	294	6	6292
regulation of transcription by carbon catabolites	1.3436E-3	27	13	2	6292
cellular response to nutrient	1.3436E-3	27	13	2	6292
protein ubiquitination	2.5786E-3	27	65	3	6292
urea metabolic process	4.2912E-3	27	1	1	6292
Golgi inheritance	4.2912E-3	27	1	1	6292
cellular macromolecule catabolic process	4.8063E-3	27	265	5	6292
cellular protein catabolic process	5.67E-3	27	171	4	6292
protein modification by small protein conjugation	5.6904E-3	27	86	3	6292
G2/M transition of mitotic cell cycle	6.7039E-3	27	29	2	6292
cellular catabolic process	7.164E-3	27	415	6	6292
developmental growth involved in morphogenesis	8.5646E-3	27	2	1	6292
interspecies interaction between organisms	8.5646E-3	27	2	1	6292
vesicle transport along actin filament	8.5646E-3	27	2	1	6292
actin filament-based movement	8.5646E-3	27	2	1	6292
developmental growth	8.5646E-3	27	2	1	6292
unidimensional cell growth	8.5646E-3	27	2	1	6292
membrane addition at site of cytokinesis	8.5646E-3	27	2	1	6292
cellular response to external stimulus	9.6706E-3	27	35	2	6292
cellular response to extracellular stimulus	9.6706E-3	27	35	2	6292
cellular response to nutrient levels	9.6706E-3	27	35	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
protein binding	1.2818E-4	27	612	10	6292
protein binding, bridging	3.2128E-3	27	20	2	6292
ligase activity	3.5524E-3	27	150	4	6292
calmodulin binding	4.2912E-3	27	1	1	6292
ATP-dependent protein binding	4.2912E-3	27	1	1	6292
allophanate hydrolase activity	4.2912E-3	27	1	1	6292
urea carboxylase activity	4.2912E-3	27	1	1	6292
ligase activity, forming carbon-nitrogen bonds	7.2853E-3	27	94	3	6292
myosin I binding	8.5646E-3	27	2	1	6292
hydrogen-exporting ATPase activity, phosphorylative mechanism	8.5646E-3	27	2	1	6292
6-phosphofructokinase activity	8.5646E-3	27	2	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis