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Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: long-chain fatty acid-CoA ligase activity
Acc: GO:0004467
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
Synonyms:
  • lignoceroyl-CoA synthase activity
  • palmitoyl coenzyme A synthetase
  • palmitoyl-CoA synthase
  • arachidonyl-CoA synthetase
  • LCFA synthetase activity
  • long-chain-fatty-acyl-CoA synthetase activity
  • long-chain acyl-CoA synthetase II
  • acyl-activating enzyme activity
  • long-chain acyl-CoA synthetase activity
  • long-chain fatty acid-CoA ligase activity
  • pristanoyl-CoA synthetase
  • long chain fatty acyl-CoA synthetase activity
  • long-chain acyl-coenzyme A synthetase activity
  • thiokinase
  • palmitoyl-CoA ligase
  • oleoyl-CoA synthetase
  • FAA1
  • acyl-CoA synthetase activity
  • long-chain-fatty-acid-CoA ligase activity
  • long-chain acyl CoA synthetase activity
  • stearoyl-CoA synthetase
  • fatty acid thiokinase (long chain) activity
  • long-chain fatty acid activation
  • fatty acid thiokinase (long-chain) activity
  • long-chain fatty acyl coenzyme A synthetase activity
  • ACS3
  • long-chain acyl-CoA synthetase I
Proteins in PDR annotated with:
   This term: 67 [Search]
   Term or descendants: 67 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004467 - long-chain fatty acid-CoA ligase activity (interactive image map)

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