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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 410.35
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC45
  • replication fork
  • pre-replicative complex
  • DNA replication initiation
  • DNA strand elongation involved in DNA replication
  • pre-replicative complex assembly
  • DNA binding
  • DPB11
  • replication fork
  • DNA replication initiation
  • DNA replication checkpoint
  • lagging strand elongation
  • recombinational repair
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • protein binding
  • DPB2
  • replication fork
  • nucleus
  • cytoplasm
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • DNA binding
  • nucleotidyltransferase activity
  • DNA-directed DNA polymerase activity
  • double-stranded DNA binding
  • transferase activity
  • DPB3
  • replication fork
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • chromatin silencing at telomere
  • DNA binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • double-stranded DNA binding
  • transferase activity
  • MCM2
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MCM3
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MCM4
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MCM5
  • replication fork
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • establishment of chromatin silencing
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MCM6
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MCM7
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • ATP binding
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • ORC1
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • ATPase activity
  • DNA replication origin binding
  • ORC2
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC3
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC4
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC5
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • ATPase activity
  • DNA replication origin binding
  • ORC6
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • POL2
  • replication fork
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • DNA synthesis involved in DNA repair
  • chromatin silencing at telomere
  • nucleotide binding
  • nucleic acid binding
  • DNA binding
  • zinc ion binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • metal ion binding
  • double-stranded DNA binding
  • transferase activity
  • POL3
  • replication fork
  • delta DNA polymerase complex
  • mutagenesis
  • lagging strand elongation
  • base-excision repair
  • leading strand elongation
  • maintenance of fidelity involved in DNA-dependent DNA replication
  • nucleotide-excision repair
  • mismatch repair
  • postreplication repair
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
  • POL31
  • delta DNA polymerase complex
  • mutagenesis
  • lagging strand elongation
  • base-excision repair
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • postreplication repair
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
  • POL32
  • nucleus
  • delta DNA polymerase complex
  • mutagenesis
  • lagging strand elongation
  • base-excision repair
  • leading strand elongation
  • telomere maintenance
  • nucleotide-excision repair
  • mismatch repair
  • postreplication repair
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein-DNA complex 1.0534E-39 20 57 19 6292
    pre-replicative complex 1.1263E-32 20 16 13 6292
    chromosomal part 1.4934E-29 20 237 20 6292
    chromosome 3.0465E-28 20 274 20 6292
    nuclear chromosome part 3.5063E-26 20 190 18 6292
    nuclear chromosome 1.0636E-24 20 228 18 6292
    non-membrane-bounded organelle 3.8645E-17 20 959 20 6292
    intracellular non-membrane-bounded organelle 3.8645E-17 20 959 20 6292
    origin recognition complex 4.5084E-16 20 6 6 6292
    nuclear origin of replication recognition complex 4.5084E-16 20 6 6 6292
    replication fork 1.6786E-15 20 42 9 6292
    MCM complex 3.1498E-15 20 7 6 6292
    nucleoplasm part 2.1033E-14 20 245 13 6292
    nucleoplasm 5.5723E-14 20 264 13 6292
    nuclear part 6.298E-14 20 1103 19 6292
    DNA polymerase complex 9.3955E-14 20 10 6 6292
    protein complex 4.9584E-12 20 1137 18 6292
    nuclear replisome 8.1795E-12 20 18 6 6292
    replisome 8.1795E-12 20 18 6 6292
    nuclear replication fork 1.7013E-11 20 20 6 6292
    nuclear lumen 5.7536E-11 20 453 13 6292
    macromolecular complex 1.0598E-10 20 1635 19 6292
    organelle part 1.4703E-9 20 2282 20 6292
    intracellular organelle part 1.4703E-9 20 2282 20 6292
    organelle lumen 6.4211E-9 20 660 13 6292
    intracellular organelle lumen 6.4211E-9 20 660 13 6292
    nucleus 6.7236E-9 20 2041 19 6292
    membrane-enclosed lumen 1.3271E-8 20 700 13 6292
    delta DNA polymerase complex 2.7472E-8 20 3 3 6292
    epsilon DNA polymerase complex 2.7361E-7 20 5 3 6292
    nucleotide-excision repair complex 3.5228E-5 20 21 3 6292
    intracellular organelle 1.6178E-4 20 4070 20 6292
    organelle 1.6258E-4 20 4071 20 6292
    membrane-bounded organelle 5.0591E-4 20 3771 19 6292
    intracellular membrane-bounded organelle 5.0591E-4 20 3771 19 6292
    intracellular part 7.7919E-3 20 4938 20 6292
    intracellular 9.0491E-3 20 4975 20 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA-dependent DNA replication 1.6462E-39 20 82 20 6292
    DNA replication 1.3367E-35 20 123 20 6292
    pre-replicative complex assembly 2.0565E-31 20 13 12 6292
    DNA replication initiation 1.8107E-29 20 33 14 6292
    protein-DNA complex assembly 5.9999E-23 20 39 12 6292
    DNA metabolic process 1.7291E-21 20 585 20 6292
    cellular macromolecule biosynthetic process 2.8607E-15 20 1187 20 6292
    macromolecule biosynthetic process 2.9594E-15 20 1189 20 6292
    leading strand elongation 6.3683E-15 20 15 7 6292
    DNA strand elongation 1.5755E-14 20 31 8 6292
    DNA strand elongation involved in DNA replication 1.5755E-14 20 31 8 6292
    cellular macromolecular complex assembly 2.4625E-14 20 182 12 6292
    lagging strand elongation 3.1323E-14 20 18 7 6292
    nucleic acid metabolic process 9.8605E-14 20 1415 20 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7.5906E-13 20 1566 20 6292
    cellular biosynthetic process 7.6887E-13 20 1567 20 6292
    mismatch repair 8.599E-13 20 27 7 6292
    biosynthetic process 1.1992E-12 20 1602 20 6292
    DNA unwinding involved in replication 1.3333E-12 20 14 6 6292
    cellular macromolecular complex subunit organization 1.7305E-12 20 259 12 6292
    macromolecular complex assembly 4.574E-12 20 281 12 6292
    negative regulation of gene expression, epigenetic 6.5303E-12 20 100 9 6292
    gene silencing 6.5303E-12 20 100 9 6292
    regulation of gene expression, epigenetic 6.5303E-12 20 100 9 6292
    chromatin silencing 6.5303E-12 20 100 9 6292
    cellular nitrogen compound metabolic process 8.9131E-12 20 1770 20 6292
    nitrogen compound metabolic process 1.1299E-11 20 1791 20 6292
    nucleotide-excision repair 1.1979E-11 20 38 7 6292
    DNA geometric change 1.7013E-11 20 20 6 6292
    DNA duplex unwinding 1.7013E-11 20 20 6 6292
    negative regulation of macromolecule biosynthetic process 3.1154E-11 20 175 10 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.1292E-11 20 180 10 6292
    negative regulation of nitrogen compound metabolic process 4.1292E-11 20 180 10 6292
    negative regulation of biosynthetic process 6.7192E-11 20 189 10 6292
    negative regulation of cellular biosynthetic process 6.7192E-11 20 189 10 6292
    macromolecular complex subunit organization 7.7538E-11 20 357 12 6292
    negative regulation of macromolecule metabolic process 7.8605E-11 20 192 10 6292
    negative regulation of cellular metabolic process 1.8259E-10 20 209 10 6292
    cellular component assembly 1.879E-10 20 385 12 6292
    negative regulation of metabolic process 1.9144E-10 20 210 10 6292
    negative regulation of transcription, DNA-dependent 3.9622E-10 20 157 9 6292
    negative regulation of RNA metabolic process 4.1947E-10 20 158 9 6292
    chromatin silencing at silent mating-type cassette 4.7419E-10 20 33 6 6292
    negative regulation of transcription 5.8607E-10 20 164 9 6292
    negative regulation of gene expression 5.8607E-10 20 164 9 6292
    negative regulation of cellular process 1.0681E-9 20 250 10 6292
    negative regulation of biological process 1.2007E-9 20 253 10 6292
    cellular macromolecule metabolic process 1.5096E-9 20 2285 20 6292
    macromolecule metabolic process 2.629E-9 20 2349 20 6292
    DNA conformation change 1.6518E-8 20 58 6 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.4224E-7 20 415 10 6292
    regulation of nitrogen compound metabolic process 1.4552E-7 20 416 10 6292
    cellular component biogenesis 1.6138E-7 20 694 12 6292
    primary metabolic process 1.757E-7 20 2896 20 6292
    regulation of macromolecule biosynthetic process 3.4606E-7 20 456 10 6292
    cellular metabolic process 4.4416E-7 20 3033 20 6292
    regulation of cellular biosynthetic process 4.7829E-7 20 472 10 6292
    regulation of biosynthetic process 4.8786E-7 20 473 10 6292
    regulation of transcription, DNA-dependent 5.4328E-7 20 358 9 6292
    regulation of RNA metabolic process 6.1131E-7 20 363 9 6292
    regulation of macromolecule metabolic process 6.533E-7 20 488 10 6292
    regulation of transcription 9.849E-7 20 384 9 6292
    metabolic process 9.9232E-7 20 3157 20 6292
    regulation of primary metabolic process 1.0595E-6 20 514 10 6292
    DNA repair 1.2228E-6 20 192 7 6292
    regulation of cellular metabolic process 1.5626E-6 20 536 10 6292
    regulation of metabolic process 1.8853E-6 20 547 10 6292
    mutagenesis 2.2798E-6 20 9 3 6292
    regulation of gene expression 3.3983E-6 20 445 9 6292
    response to DNA damage stimulus 4.8779E-6 20 236 7 6292
    base-excision repair 5.9345E-6 20 12 3 6292
    cellular response to stress 1.8977E-5 20 290 7 6292
    postreplication repair 2.1745E-5 20 18 3 6292
    regulation of cellular process 5.5506E-5 20 796 10 6292
    regulation of biological process 7.5101E-5 20 824 10 6292
    transcription, DNA-dependent 8.3876E-5 20 503 8 6292
    RNA biosynthetic process 9.0017E-5 20 508 8 6292
    cellular response to stimulus 1.0636E-4 20 379 7 6292
    transcription 1.6227E-4 20 552 8 6292
    cellular component organization 1.9067E-4 20 1582 13 6292
    biological regulation 3.9439E-4 20 1213 11 6292
    response to stress 5.7434E-4 20 497 7 6292
    obsolete_biological_process 8.3744E-4 20 60 3 6292
    cellular process 8.6878E-4 20 4426 20 6292
    maintenance of fidelity involved in DNA-dependent DNA replication 3.1786E-3 20 1 1 6292
    RNA metabolic process 6.2445E-3 20 954 8 6292
    response to stimulus 7.1454E-3 20 766 7 6292
    establishment of chromatin silencing 9.5071E-3 20 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA replication origin binding 7.6335E-13 20 13 6 6292
    ATP-dependent DNA helicase activity 8.1795E-12 20 18 6 6292
    chromatin binding 4.7419E-10 20 33 6 6292
    DNA helicase activity 5.747E-10 20 34 6 6292
    binding 1.1642E-9 20 1294 17 6292
    DNA binding 1.3478E-9 20 256 10 6292
    ATP-dependent helicase activity 5.105E-9 20 48 6 6292
    purine NTP-dependent helicase activity 5.105E-9 20 48 6 6292
    sequence-specific DNA binding 6.5852E-9 20 50 6 6292
    DNA-dependent ATPase activity 1.1899E-8 20 55 6 6292
    single-stranded DNA specific 3'-5' exodeoxyribonuclease activity 2.7472E-8 20 3 3 6292
    single-stranded DNA specific exodeoxyribonuclease activity 2.7472E-8 20 3 3 6292
    ATPase activity 1.2479E-7 20 211 8 6292
    helicase activity 1.468E-7 20 83 6 6292
    3'-5'-exodeoxyribonuclease activity 5.4611E-7 20 6 3 6292
    exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.5229E-6 20 8 3 6292
    exodeoxyribonuclease activity 2.2798E-6 20 9 3 6292
    nucleoside-triphosphatase activity 3.7211E-6 20 329 8 6292
    ATPase activity, coupled 4.6993E-6 20 149 6 6292
    hydrolase activity, acting on acid anhydrides 6.301E-6 20 353 8 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.301E-6 20 353 8 6292
    pyrophosphatase activity 6.301E-6 20 353 8 6292
    nucleic acid binding 1.1362E-5 20 666 10 6292
    hydrolase activity 2.646E-5 20 911 11 6292
    double-stranded DNA binding 4.6719E-5 20 23 3 6292
    deoxyribonuclease activity 9.5225E-5 20 29 3 6292
    exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.5437E-4 20 34 3 6292
    3'-5' exonuclease activity 1.685E-4 20 35 3 6292
    structure-specific DNA binding 3.348E-4 20 44 3 6292
    exonuclease activity 3.8219E-4 20 46 3 6292
    catalytic activity 1.143E-3 20 2150 14 6292
    DNA-directed DNA polymerase activity 4.7725E-3 20 110 3 6292
    DNA polymerase activity 5.4048E-3 20 115 3 6292

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