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Protein Overview: DPB3

General Information:
Name(s) found: DPB3 / YBR278W [SGD]
Description(s) found:
Found 33 descriptions.
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  • Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 201 amino acids

    Gene Ontology:
    Cellular Component: replication fork [TASLink to PubMed article]
    epsilon DNA polymerase complex [IDALink to PubMed article]
    Biological Process: lagging strand elongation [TASLink to PubMed article]
    leading strand elongation [TASLink to PubMed article]
    nucleotide-excision repair [TASLink to PubMed article]
    mismatch repair [TASLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEA]
    DNA-directed DNA polymerase activity [IEA][TAS]
    nucleotidyltransferase activity [IEA]
    double-stranded DNA binding [IDA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNLVKEKAP VFPISKVKKI AKCDPEYVIT SNVAISATAF AAELFVQNLV EESLVLAQLN  60
   61 SKGKTSLRLS LNSIEECVEK RDNFRFLEDA IKQLKKNSAL DKKRELNMQP GRSDQEVVIE 120
  121 EPELHEDDGV EEEEEEDEVS EEEEPVHNEE LLDDSKDQQN DKSTRSVASL LSRFQYKSAL 180
  181 DVGEHSDSSD IEVDHTKSTD P

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DPB2 DPB3 DPB4 POL2
    View Details (MIPS) Mewes HW, et al. (2004) CDC45 DPB11 DPB2 DPB3 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL2 POL3 POL31 POL32
    View Details Krogan NJ, et al. (2006) DPB2 DPB3 DPB4 INM1 MBA1 MCM2 POL2 RPN4
    View Details Qiu et al. (2008) CDC45 DPB11 DPB2 DPB3 DPB4 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC2 ORC5 POL1 POL2 POL3 POL30 POL31 POL32 PRI1 PRI2 RAD30 REV3 REV7 SLD2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DPB3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..109] ORFEUS 12.86 Negative cofactor 2, NC2, alpha chain
    2 View Details [110..201] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  7.11495094825518 bayes_pls_golite062009
  • DNA polymerase activity
    		•  7.07317269086318 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  4.8449005461991 bayes_pls_golite062009
  • DNA binding
    		•  4.24660531286828 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.14026521609645 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.91807454227165 bayes_pls_golite062009
  • binding
    		•  3.14832737946099 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.58437727844306 bayes_pls_golite062009
  • transcription factor activity
    		•  2.39322722597434 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.253406442565 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.11715713953033 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.72510004749125 bayes_pls_golite062009
  • transferase activity
    		•  1.52384026846369 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.14016287166607 bayes_pls_golite062009
  • transcription activator activity
    		•  1.12739348005764 bayes_pls_golite062009
  • protein binding
    		•  1.01897642648285 bayes_pls_golite062009
  • transcription factor binding
    		•  1.01773884290535 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.840442755533537 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.390904810536807 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0585868733603467 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle