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Protein Overview: Csk-PH

General Information:
Name(s) found: Csk-PH / FBpp0289773 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene C-terminal Src kinase is referred to in FlyBase by the symbol Dmel\Csk (CG42317, FBgn0259217). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7458992..7476418. It has the cytological map location 86E13. There is experimental evidence that it has the molecular function</span>: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of growth; adherens junction maintenance; positive regulation of programmed cell death; establishment or maintenance of epithelial cell apical/basal polarity; epithelial structure maintenance; negative regulation of cell proliferation; germarium-derived egg chamber formation. 27 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsal mesothoracic disc; anterior crossvein; wing vein L4; wing; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 805 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: negative regulation of growth [IGI][IMP]
    germarium-derived egg chamber formation [IMP]
    intracellular signaling pathway [IEA]
    epithelial structure maintenance [IMP]
    negative regulation of cell proliferation [IMP]
    establishment or maintenance of epithelial cell apical/basal polarity [IMP]
    positive regulation of programmed cell death [IMP]
    adherens junction maintenance [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [IDA][ISS][NAS]
    protein binding [IEA]
    non-membrane spanning protein tyrosine kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESIAIGFL QYIITINYDD EEAQARKTSH EKSQKPKPKP EENHKEKEAI SRKASGEGDL  60
   61 ITVEIKQGLL RKQTATTTTG QAMNSHATAT QNGQTTVVGH HRGFSQPSVT VAAAAATGST 120
  121 AGDPWFLQTT GHQMPPTAPL RHNKRPAPQP NAVLGAGSSG TAPGSAVGAV LLHQQQLSQS 180
  181 QPHIVPPSIP PHHHHHRENN VHPIQAGAAA ALHLSSHALN SHNLISSASN HSPKSPSQTQ 240
  241 QQQQTTNQQQ QQQQQQASHS ILSTFAPAPT VAAVQPAGSQ SVAGTAAAVA AVAQQQQQQH 300
  301 LQLLANCPPG GAGLMSSSLN AAQMGMHGAE RALPPKSLAL SGSQHGSNML LHTAPQPPQA 360
  361 SQPAAVVGVS GSGSAGMSTS LHSFDINGVT AGSGVNASSA WSSGSTTAMN HASLSPTALA 420
  421 PQQGRSRCEV KLNAMPWFHG SITRDEAEHL LQPREDGLFL VRESTNFPGD YTLCVCFQSK 480
  481 VEHYRVKYLE NKLTIDDEEY FENLGQLVAH YEADADGLCT QLIKCLPKLG KQEFCINSKD 540
  541 FVDKGWVIPE AELQLRESIG KGEFGDVMLG ILRNEKVAVK MLKDEGAVQK FLAEASVMTT 600
  601 LEHDNLVKFI GLVFTSKHLY LVTEYMSKGS LVDYLRSRGR QHITKKDQII FAYDTASGME 660
  661 YLEAKKVVHR DLAARNVLIS EDCVAKVSDF GLAREECYNL DVGKLPIKWT APEALKNGRF 720
  721 SNKSDMWSFG ILLWEIYSFG RVPYPRIPLA DVVKHVEVGY KMEAPEGCPP EIYEMMRQAW 780
  781 DLNPAKRPTF AELKVKLQLL NNATA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..189] deduced N/A No confident structure predictions are available.
    2 View Details [190..342] deduced N/A No confident structure predictions are available.
    3 View Details [343..805] PSI-BLAST 102.0 Carboxyl-terminal src kinase (csk)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  4.41722924924158 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • actin binding
    		•  3.91045208670052 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • CD8 receptor binding
    		•  3.34636716492159 bayes_pls_golite062009
  • protein binding
    		•  3.13677730481089 bayes_pls_golite062009
  • binding
    		•  3.06905798270146 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • actin filament binding
    		•  2.72908433443928 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.65451266834284 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.4913932444423 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.08937039830657 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • PTB domain binding
    		•  1.56656184134104 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.34867629228264 bayes_pls_golite062009
  • signal transducer activity
    		•  1.34867629228264 bayes_pls_golite062009
  • transporter activity
    		•  1.30447542854757 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • tubulin binding
    		•  1.13686658158825 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08558010881058 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • structural molecule activity
    		•  0.989403012920596 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.820987609295422 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.80673395326897 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • microtubule binding
    		•  0.734274677384472 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.546647574638943 bayes_pls_golite062009
  • insulin binding
    		•  0.546269851452869 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.52430033936893 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.371928447183203 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.275913005279959 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.188254408239569 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • receptor binding
    		•  0.0742205785215131 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  0.0613131034808199 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • cation binding
    		•  0.046173055856133 bayes_pls_golite062009
  • metal ion binding
    		•  0.046173055856133 bayes_pls_golite062009
  • ion binding
    		•  0.0389662058697694 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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