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Protein Overview: Xpd-PA

General Information:
Name(s) found: Xpd-PA / FBpp0071503 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene Xeroderma pigmentosum D is referred to in FlyBase by the symbol Dmel\Xpd (CG9433, FBgn0015844). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17058460..17062009. It has the cytological map location 57C7. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity; ATP-dependent 5'-3' DNA helicase activity; helicase activity. There is experimental evidence that it is involved in the biological process</span>: response to DNA damage stimulus; regulation of mitosis; response to UV. 6 alleles are reported. The phenotype of these alleles is annotated with: mitotic cell cycle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 769 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    polytene chromosome puff [IDA]
    polytene chromosome interband [IDA]
    cytoplasm [IDA]
    holo TFIIH complex [ISS]
    Biological Process: regulation of mitosis [IMP]
    nucleotide-excision repair [ISS]
    response to UV [IDA]
    response to DNA damage stimulus [IDA]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: ATP binding [IEA]
    DNA binding [IEA]
    ATP-dependent 5'-3' DNA helicase activity [ISS]
    general RNA polymerase II transcription factor activity [ISS]
    helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSVDGLLV YFPYEYIYPE QYAYMLELKR SLDAKGHCLL EMPSGTGKTA TLLSLIVAYM  60
   61 VEHPETVRKL IYCSRTVPEI EKVIAELQNL MVYYERHCPN PPPFTGLVLS SRKNMCIHPE 120
  121 VSKEREGKAV DGKCYGLTAS YIRERHEMDT ETPICQYFEG FSLEGKESTL PVGVYSIDDL 180
  181 KEYGRSRNWC PYFLARYAIA HAHIVVYSYH YLLDPKIAQV VSKEMSRESC VVFDEAHNID 240
  241 NVCIDSMSVK INRRTVERST NALNHLTKLV QDIREEDTNR LNEEYQRMVQ GLKDASVQRD 300
  301 TDMILANPVL PNDVLTEVVP GNIRNADHFL SFLRRFIEYI KTRLRVHHVV QESPAGFLKD 360
  361 ISSKICIERK PLRFCAERLS SLLRTLEISD LTEYGALTLI THFATLVSTY TKGFTIIIEP 420
  421 FDDKTPTVSN PILHFSCLDS SIAMAPVFSR FQTVVITSGT LSPMDMYPKI LDFDPVVMSS 480
  481 FTMTLARPCL LPMIVSKGND QVTISSKFET REDTAVIRNY GQLLVEVAKT VPDGIVCFFT 540
  541 SYLYLESVVA SWYDQGIVDT LLRYKLLFIE TQDNAETSYA LMNYVKACDC GRGAVLLAVA 600
  601 RGKVSEGVDF DHHYGRAVLM FGIPYVYTQS RILKARLDYL RDQFQIREND FLTFDAMRHA 660
  661 AQCVGRALRG KTDYGIMIFA DKRFSRHDKR SRLPKWIQEH LVDSFCNLST EEAVQLARRW 720
  721 LRRMAQPFTR EDQLGISLLT LAQLENMEQE KLERQAQGKQ GVGGEVQEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..324] PSI-BLAST 6.69897 structure of human UAP56 in complex with ADP
    2 View Details [325..769] FFAS03 1.01 No description for 2ocaA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.47805400577115 bayes_pls_golite062009
  • dATP binding
    		•  3.90236137621968 bayes_pls_golite062009
  • adenyl deoxyribonucleotide binding
    		•  2.90098016780049 bayes_pls_golite062009
  • purine deoxyribonucleotide binding
    		•  2.90098016780049 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.72222787956584 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  2.60873257753475 bayes_pls_golite062009
  • hydrolase activity
    		•  2.55157966585974 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • endonuclease activity
    		•  1.96689197136388 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.6537049553461 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.63960194106079 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.61735400124552 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.60404584546501 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.29640539057136 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  1.12431517057397 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.11383295816593 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.595694294246159 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.394186699348086 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.360529478474946 bayes_pls_golite062009
  • nucleotide binding
    		•  0.354857598792381 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.35235724478784 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.352298062690593 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.283577486331079 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.26252931460003 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.181509771587324 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle