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View Structure Prediction Details

Protein: Xpd-PA
Organism: Drosophila melanogaster
Length: 769 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Xpd-PA.

Description E-value Query
Range		 Subject
Range
gi|157132567, gi... - gi|157132567|ref|XP_001656074.1| DNA repair helicase rad3/xp-d [Aedes aegypti], gi|108884369|gb|EAT4...
 622.0 [0..1] [760..1]

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Predicted Domain #1
Region A:
Residues: [1-324] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSVDGLLV YFPYEYIYPE QYAYMLELKR SLDAKGHCLL EMPSGTGKTA TLLSLIVAYM  60
   61 VEHPETVRKL IYCSRTVPEI EKVIAELQNL MVYYERHCPN PPPFTGLVLS SRKNMCIHPE 120
  121 VSKEREGKAV DGKCYGLTAS YIRERHEMDT ETPICQYFEG FSLEGKESTL PVGVYSIDDL 180
  181 KEYGRSRNWC PYFLARYAIA HAHIVVYSYH YLLDPKIAQV VSKEMSRESC VVFDEAHNID 240
  241 NVCIDSMSVK INRRTVERST NALNHLTKLV QDIREEDTNR LNEEYQRMVQ GLKDASVQRD 300
  301 TDMILANPVL PNDVLTEVVP GNIR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1xtjA
Description: structure of human UAP56 in complex with ADP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.47805400577115 bayes_pls_golite062009
dATP binding 3.90236137621968 bayes_pls_golite062009
adenyl deoxyribonucleotide binding 2.90098016780049 bayes_pls_golite062009
purine deoxyribonucleotide binding 2.90098016780049 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
deoxyribonuclease activity 2.72222787956584 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
endodeoxyribonuclease activity 2.60873257753475 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
endonuclease activity 1.96689197136388 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
microtubule motor activity 1.6537049553461 bayes_pls_golite062009
RNA helicase activity 1.63960194106079 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.61735400124552 bayes_pls_golite062009
RNA-dependent ATPase activity 1.60404584546501 bayes_pls_golite062009
protein-DNA loading ATPase activity 1.29640539057136 bayes_pls_golite062009
structure-specific DNA binding 1.2539059700735 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
DNA clamp loader activity 1.12431517057397 bayes_pls_golite062009
double-stranded DNA binding 1.117585097627 bayes_pls_golite062009
transcription elongation regulator activity 1.11383295816593 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
ion transmembrane transporter activity 0.595694294246159 bayes_pls_golite062009
single-stranded DNA binding 0.568457189190858 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
cation transmembrane transporter activity 0.394186699348086 bayes_pls_golite062009
purine nucleotide binding 0.360529478474946 bayes_pls_golite062009
nucleotide binding 0.354857598792381 bayes_pls_golite062009
purine ribonucleotide binding 0.35235724478784 bayes_pls_golite062009
ribonucleotide binding 0.352298062690593 bayes_pls_golite062009
mismatched DNA binding 0.31144582840038 bayes_pls_golite062009
DNA strand annealing activity 0.283577486331079 bayes_pls_golite062009
four-way junction helicase activity 0.26252931460003 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
exodeoxyribonuclease V activity 0.185603938981231 bayes_pls_golite062009
nucleotidyltransferase activity 0.181509771587324 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [325-769] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NADHFLSFLR RFIEYIKTRL RVHHVVQESP AGFLKDISSK ICIERKPLRF CAERLSSLLR  60
   61 TLEISDLTEY GALTLITHFA TLVSTYTKGF TIIIEPFDDK TPTVSNPILH FSCLDSSIAM 120
  121 APVFSRFQTV VITSGTLSPM DMYPKILDFD PVVMSSFTMT LARPCLLPMI VSKGNDQVTI 180
  181 SSKFETREDT AVIRNYGQLL VEVAKTVPDG IVCFFTSYLY LESVVASWYD QGIVDTLLRY 240
  241 KLLFIETQDN AETSYALMNY VKACDCGRGA VLLAVARGKV SEGVDFDHHY GRAVLMFGIP 300
  301 YVYTQSRILK ARLDYLRDQF QIRENDFLTF DAMRHAAQCV GRALRGKTDY GIMIFADKRF 360
  361 SRHDKRSRLP KWIQEHLVDS FCNLSTEEAV QLARRWLRRM AQPFTREDQL GISLLTLAQL 420
  421 ENMEQEKLER QAQGKQGVGG EVQEL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.01
Match: 2ocaA
Description: No description for 2ocaA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle