Protein Overview: Fps85D-PA

General Information:
Name(s) found:	Fps85D-PA / FBpp0081530 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|45549219\|ref\|NP_524288.3\| Fps oncogene analog, isoform A [Drosophila melanogaster] [NCBI NR] gi\|45446433\|gb\|AAF54367.3\| Fps oncogene analog, isoform A [Drosophila melanogaster] [NCBI NR] gi\|44888970\|sp\|P18106.3\|FPS_DROME RecName: Full=Tyrosine-protein kinase Fps85D; AltName: Full=dFer [NCBI NR] gi\|28316885\|gb\|AAO39465.1\| RH14840p [Drosophila melanogaster] [NCBI NR] Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 [Swiss-Prot] Tyrosine-protein kinase Fer OS=Drosophila melanogaster GN=FER PE=1 SV=3 [Swiss-Prot] The gene Fps oncogene analog is referred to in FlyBase by the symbol Dmel\Fps85D (CG8874, FBgn0000723). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5193321..5220265. It has the cytological map location 85D13-85D15. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: dorsal closure, elongation of leading edge cells; dorsal closure; actin filament bundle formation; axon guidance; photoreceptor cell morphogenesis; dorsal closure, amnioserosa morphology change. 18 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; amnioserosa; ventral midline. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.1.112) (dFer) [DrosMelano7227.FASTAC.txt] CG8874-PA, isoform A [Drosophila melanogaster]gi\|28316885\|gb\|AAO39465.1\| RH14840p [Drosophila melanogaster]gi\|45549219\|ref\|NP_524288.3\| CG8874-PA [Drosophila melanogaster]gi\|44888970\|sp\|P18106\|FPS_DROME Tyrosine-protein kinase Fps85D (dFer) [nrdb_11152004_Chlamydomonas] type=protein; loc=3R:complement(5193963..5194114,5194178..5194360,5194421..5194549,5194619..5194705,5194777..5194990,5195058..5195432,5196737..5198299,5198478..5198655,5198712..5198990,5199053..5199389,5199501..5199597,5216608..5216795,5218463..5218658); [fly-100309-contam.fasta] RH14840p [Drosophila melanogaster] [nr-271106-contam.fasta] Tyrosine-protein kinase Fps85D (dFer) [nr-271106-contam.fasta] CG8874-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] Fps oncogene analog CG8874-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3R:complement(5193963..5194114,5194178..5194360,5194421..5194549,5194619..5194705,5194777..5194990,5195058..5195432,5196737..5198299,5198478..5198655,5198712..5198990,5199053..5199389,5199501..5199597,5216608..5216795,5218463..5218658); ID=FBpp0081530; name=Fps85D-PA; parent=FBgn0000723,FBtr0082052; dbxref=GB_protein:AAF54367.2,FlyBase:FBpp0081530,FlyBase_Annotation_IDs:CG8874-PA,GB_protein:AAF54367.3,REFSEQ:NP_524288,GB_protein:AAF54367; MD5=6a9bba944a22b42dc6ab2af95af741c5; length=1325; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:complement(5193963..5194114,5194178..5194360,5194421..5194549,5194619..5194705,5194777..5194990,5195058..5195432,5196737..5198299,5198478..5198655,5198712..5198990,5199053..5199389,5199501..5199597,5216608..5216795,5218463..5218658); ID=FBpp0081530; name=Fps85D-PA; parent=FBgn0000723,FBtr0082052; dbxref=GB_protein:AAF54367.2,FlyBase:FBpp0081530,FlyBase_Annotation_IDs:CG8874-PA,GB_protein:AAF54367.3,REFSEQ:NP_524288,GB_protein:AAF54367; MD5=6a9bba944a22b42dc6ab2af95af741c5; length=1325; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3R:complement(5193963..5194114,5194178..5194360,5194421..5194549,5194619..5194705,5194777..5194990,5195058..5195432,5196737..5198299,5198478..5198655,5198712..5198990,5199053..5199389,5199501..5199597,5216608..5216795,5218463..5218658); ID=FBpp0081530; name=Fps85D-PA; parent=FBgn0000723,FBtr0082052; dbxref=GB_protein:AAF54367.2,FlyBase:FBpp0081530,FlyBase_Annotation_IDs:CG8874-PA,GB_protein:AAF54367.3,REFSEQ:NP_524288,GB_protein:AAF54367,FlyMine:FBpp0081530,modMine:FBpp0081530; MD5=6a9bba944a22b42dc6ab2af95af741c5; length=1325; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3R:complement(join(9392741..9392936,9390886..9391073,9373779..9373875,9373331..9373667,9372990..9373268,9372756..9372933,9371015..9372577,9369336..9369710,9369055..9369268,9368897..9368983,9368699..9368827,9368456..9368638,9368241..9368392)); ID=FBpp0081530; name=FER-PA; parent=FBgn0000723,FBtr0082052; dbxref=GB_protein:AAF54367.2,FlyBase:FBpp0081530,FlyBase_Annotation_IDs:CG8874-PA,GB_protein:AAF54367.3,REFSEQ:NP_524288,GB_protein:AAF54367,FlyMine:FBpp0081530,modMine:FBpp0081530; MD5=6a9bba944a22b42dc6ab2af95af741c5; length=1325; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3R:complement(join(9392741..9392936,9390886..9391073,9373779..9373875,9373331..9373667,9372990..9373268,9372756..9372933,9371015..9372577,9369336..9369710,9369055..9369268,9368897..9368983,9368699..9368827,9368456..9368638,9368241..9368392)); ID=FBpp0081530; name=FER-PA; parent=FBgn0000723,FBtr0082052; dbxref=GB_protein:AAF54367.2,FlyBase:FBpp0081530,FlyBase_Annotation_IDs:CG8874-PA,GB_protein:AAF54367.3,REFSEQ:NP_524288,GB_protein:AAF54367,FlyMine:FBpp0081530,modMine:FBpp0081530; MD5=6a9bba944a22b42dc6ab2af95af741c5; length=1325; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0081530 type=protein; loc=3R:complement(join(9392741..9392936,9390886..9391073,9373779..9373875,9373331..9373667,9372990..9373268,9372756..9372933,9371015..9372577,9369336..9369710,9369055..9369268,9368897..9368983,9368699..9368827,9368456..9368638,9368241..9368392)); ID=FBpp0081530; name=FER-PA; parent=FBgn0000723,FBtr0082052; dbxref=GB_protein:AAF54367.2,FlyBase:FBpp0081530,FlyBase_Annotation_IDs:CG8874-PA,GB_protein:AAF54367.3,REFSEQ:NP_524288,GB_protein:AAF54367,FlyMine:FBpp0081530,modMine:FBpp0081530; MD5=6a9bba944a22b42dc6ab2af95af741c5; length=1325; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3R:complement(join(9392741..9392936,9390886..9391073,9373779..9373875,9373331..9373667,9372990..9373268,9372756..9372933,9371015..9372577,9369336..9369710,9369055..9369268,9368897..9368983,9368699..9368827,9368456..9368638,9368241..9368392)); ID=FBpp0081530; name=FER-PA; parent=FBgn0000723,FBtr0082052; dbxref=GB_protein:AAF54367.2,FlyBase:FBpp0081530,FlyBase_Annotation_IDs:CG8874-PA,GB_protein:AAF54367.3,REFSEQ:NP_524288,GB_protein:AAF54367,UniProt/Swiss-Prot:P18106,FlyMine:FBpp0081530,modMine:FBpp0081530; MD5=6a9bba944a22b42dc6ab2af95af741c5; length=1325; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1325 amino acids
Gene Ontology:
Cellular Component:	adherens junction [IDA] cytoplasm [NAS] membrane [NAS] plasma membrane [IDA]
Biological Process:	dorsal closure [IGI] photoreceptor cell morphogenesis [IMP] dorsal closure, elongation of leading edge cells [IMP] axon guidance [IMP] dorsal closure, amnioserosa morphology change [IMP] protein amino acid phosphorylation [IEA][NAS] actin filament bundle assembly [IMP]
Molecular Function:	ATP binding [IEA] protein tyrosine kinase activity [ISS][NAS] protein binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFSSALQSR AAHEALIVRQ DAELRLMETM KRSIQMKAKC DKEYAISLTA VAQQGLKIDR  60
   61 ADEMQGSLIS KSWRSYMDEL DHQAKQFKFN AEQLEVVCDK LTHLSQDKRK ARKAYQEEHA 120
  121 KIAARLNHLT DEVVRKKSEY QKHLEGYKAL RTRFEENYIK APSRSGRKLD DVRDKYQKAC 180
  181 RKLHLTHNEY VLSITEAIEV EKDFRNVLLP GLLEHQQSVQ ESFILLWRNI LQEAAQYGDL 240
  241 TADKYKEIQK RIDTVIGSIN PTEEYGEFTE KYKTSPTTPL LFQFDETLIQ DIPGKLQSST 300
  301 LTVDNLTVDW LRNRLQELEG AVRDCQEKQM KMIEHVNGGS PVANGSIISN GSNTSNGIQS 360
  361 NKDSLCRQSK DLNALRCQEK QKQKLVDMIK CALNEVGCEE LPSGCDDDLT LEQNFIENGY 420
  421 NNEQQRSNST SSPGLGIMNE LMRRGGVLTL LRGRGRHFKR KSTPQPATPM TRSRQGRFNK 480
  481 LQPRSQSLGS LSVIRDGNGP SPARYEPITN HRLRQAASVH YLGEEIATSS TNPPDLTRLR 540
  541 RTQCSMLCLG EDEEPVVLAS PAPLTQLTAA VLTNTNNNHI YADLELDKKK DTSPSPECKG 600
  601 EQIQPKKEQI RIEINQTAPQ NSIDAHLDRI DELNRVLDDR LKRTLQPSDD VNAIESAEEN 660
  661 HIQTRKLAKD PDSQTKRSSS SSSECRSSKD TSHSKKRSLS FSQKSISNIF SNLKEFSKSP 720
  721 LVRMGKNHIL NEEQDAKRTQ PSQHHHSSGS DCPTNSSSSS SNNNNNNKNT SSNSNHSASQ 780
  781 STIITSTITT TITTTTTTTP SKENSRLKFK VPKIQKKSKA IRNTFRSKLL NFQLKRSKPC 840
  841 KQCTKRRRIH PSKSVFDFAK EFEVEQPAGS AADEQFCNCP PAGQKPVKPS VQISGHKDHP 900
  901 FESSSGELDE NSDRDIDNDE EEEDSASDDV LSMKDHCYCV PSLAASISLS TNRPLYEEEW 960
  961 FHGVLPREEV VRLLNNDGDF LVRETIRNEE SQIVLSVCWN GHKHFIVQTT GEGNFRFEGP1020
 1021 PFASIQELIM HQYHSELPVT VKSGAILRRP VCRERWELSN DDVVLLERIG RGNFGDVYKA1080
 1081 KLKSTKLDVA VKTCRMTLPD EQKRKFLQEG RILKQYDHPN IVKLIGICVQ KQPIMIVMEL1140
 1141 VLGGSLLTYL RKNSNGLTTR QQMGMCRDAA AGMRYLESKN CIHRDLAARN CLVDLEHSVK1200
 1201 ISDFGMSREE EEYIVSDGMK QIPVKWTAPE ALNFGKYTSL CDVWSYGILM WEIFSKGDTP1260
 1261 YSGMTNSRAR ERIDTGYRMP TPKSTPEEMY RLMLQCWAAD AESRPHFDEI YNVVDALILR1320
 1321 LDNSH

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..292]	PSI-BLAST	26.69897	No description for 2eflA was found.
2	View Details	[293..436]	PSI-BLAST	5.0	Tropomyosin
3	View Details	[437..537]	FFAS03	2.49	Solution structure of the human FES SH2 domain
4	View Details	[538..738]	MSA	1.321994	View MSA. No confident structure predictions are available.
5	View Details	[739..799]	deduced	N/A	No confident structure predictions are available.
6	View Details	[800..1325]	PSI-BLAST	121.0	No description for 2h8hA was found.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
phosphoinositide 3-kinase binding	3.43994026029707	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	3.41480681854114	bayes_pls_golite062009
transmembrane receptor protein kinase activity	3.40140621607334	bayes_pls_golite062009
CD8 receptor binding	3.34636716492159	bayes_pls_golite062009
epidermal growth factor receptor binding	2.9751846707539	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
ion transmembrane transporter activity	2.52531786618214	bayes_pls_golite062009
cation transmembrane transporter activity	2.46424348876434	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.37122853419919	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
SH2 domain binding	2.08937039830657	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.9016235206634	bayes_pls_golite062009
actin binding	1.87817875565699	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity	1.66669268613198	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
vinculin binding	1.63216315345235	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
PTB domain binding	1.56656184134104	bayes_pls_golite062009
growth factor binding	1.53863828216563	bayes_pls_golite062009
MAP kinase kinase activity	1.42275431028856	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
tubulin binding	1.13686658158825	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	1.10045286406485	bayes_pls_golite062009
transforming growth factor beta receptor activity	1.10045286406485	bayes_pls_golite062009
cation channel activity	1.04999722123563	bayes_pls_golite062009
insulin receptor substrate binding	0.98689034826741	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
JUN kinase kinase kinase kinase activity	0.886904175966993	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
actin filament binding	0.794152600084	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.75189004129952	bayes_pls_golite062009
microtubule binding	0.734274677384472	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
insulin binding	0.546269851452869	bayes_pls_golite062009
activin binding	0.510364757301021	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
3-phosphoinositide-dependent protein kinase binding	0.372842462336059	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
channel activity	0.287189255116606	bayes_pls_golite062009
passive transmembrane transporter activity	0.287189255116606	bayes_pls_golite062009
kinase binding	0.26752427107238	bayes_pls_golite062009
substrate-specific channel activity	0.261869836686301	bayes_pls_golite062009
ion channel activity	0.241519346930618	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
insulin receptor activity	0.188254408239569	bayes_pls_golite062009
cell adhesion molecule binding	0.150740450460731	bayes_pls_golite062009
JUN kinase kinase kinase activity	0.0613131034808199	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
cation binding	0.046173055856133	bayes_pls_golite062009
metal ion binding	0.046173055856133	bayes_pls_golite062009
ion binding	0.0389662058697694	bayes_pls_golite062009
protein kinase binding	0.00674998152095019	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: Fps85D-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: