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Protein Overview: dhs-14

General Information:
Name(s) found: dhs-14 / CE23899 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00000977 locus:dhs-14 status:Confirmed UniProt:Q9N5G3 protein_id:CCD65483.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 279 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: estrogen biosynthetic process [IEALink to PubMed article]
    tetrahydrobiopterin biosynthetic process [IEALink to PubMed article]
    poly-hydroxybutyrate biosynthetic process [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    fatty acid biosynthetic process [IEALink to PubMed article]
    cellular metabolic process [IEALink to PubMed article]
    Molecular Function: estradiol 17-beta-dehydrogenase activity [IEALink to PubMed article]
    sepiapterin reductase activity [IEALink to PubMed article]
    coenzyme binding [IEALink to PubMed article]
    3-oxoacyl-[acyl-carrier-protein] reductase activity [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    NAD or NADH binding [IEALink to PubMed article]
    3-hydroxybutyrate dehydrogenase activity [IEALink to PubMed article]
    acetoacetyl-CoA reductase activity [IEALink to PubMed article]
    2-deoxy-D-gluconate 3-dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRFSGKVAL VTGSSNGIGR ATAVLLAQEG AKVTITGRNA DRLEETRQEI LKSGVPEDHV  60
   61 LSIATDLATE KGQDELVNST IQKFGRLDIL VNNAGAAFND DQGRVGVDQD VSVYDRIMQI 120
  121 NMRSVVTLTQ KAKEHLVKAK GEVVNVSSIG AGPQAQPTFM YYAMSKAALD QYTRSAAIDL 180
  181 IQYGVRVNSV SPGAVVTGFG EAMGMPADMH EKYGHFMESR KECIPCGKMG QPIDIANIIA 240
  241 FLADRKLSSY IIGQSIVADG GSTLVMGMQA HNFMDLLKQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..279] PSI-BLAST 61.69897 Crystal Structure of Short-Chain Dehydrogenase/Reductase of unknown Function from Caenorhabditis Elegans with Cofactor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • retinol dehydrogenase activity
    		•  4.1750549780559 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  3.06391460989761 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  3.02758902218302 bayes_pls_golite062009
  • ethanol binding
    		•  3.01624801418439 bayes_pls_golite062009
  • retinol binding
    		•  2.89007863838685 bayes_pls_golite062009
  • L-iditol 2-dehydrogenase activity
    		•  2.85461175493562 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  2.344389379767 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  2.03039843216597 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • L-arabinitol 2-dehydrogenase activity
    		•  1.54130379492877 bayes_pls_golite062009
  • alcohol binding
    		•  1.51091775360793 bayes_pls_golite062009
  • all-trans retinal binding
    		•  1.47861183836779 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  1.27032644348698 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  1.19042587095474 bayes_pls_golite062009
  • sorbose reductase activity
    		•  1.06293597394863 bayes_pls_golite062009
  • receptor activity
    		•  1.02559644924534 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.01627645289834 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.973650203491298 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • signal transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • transporter activity
    		•  0.793769336118517 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.729242797855749 bayes_pls_golite062009
  • 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
    		•  0.695969796208571 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  0.69372321031969 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.635891484075352 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.583772223704381 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.576163737662951 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.532187027260366 bayes_pls_golite062009
  • DNA binding
    		•  0.525227236870065 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.459537641913493 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.44922383360529 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  0.439912268968251 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.300373102236296 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.239024094835991 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.177044638410302 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.165260811069909 bayes_pls_golite062009
  • methylenetetrahydrofolate dehydrogenase activity
    		•  0.124826575912808 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  0.118312276550651 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0257250793986203 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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