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Protein Overview: cyp-13A12

General Information:
Name(s) found: cyp-13A12 / CE15823 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00008810 locus:cyp-13A12 status:Partially_confirmed UniProt:O17807 protein_id:CAB04113.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 518 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: electron transport [IEALink to PubMed article]
    Molecular Function: iron ion binding [IEALink to PubMed article]
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [IEALink to PubMed article]
    monooxygenase activity [IEALink to PubMed article]
    heme binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIIFLAILT SIIGVLSFYL WTWSYWKRRG IAGPSGYPIL GSALEMLSSE NPPYLQLKEW  60
   61 TKQYGKVYGI TEGLSRTLVI SDPDLVQEVF VKQYDNFFGR KLNPIQGDPN KDKRVNLFSS 120
  121 QGHRWKRLRT ISSPTFSNNS LRKLKTTVEE CAVELLRHIE QHTDGGQPID LLDFYQEFTL 180
  181 DVIGRIAMGQ TDSQMFKNPL LPYVRAVFGE PRKGLFLSGS LAPWIGPILR MVMFSLPNIV 240
  241 KNPAVHVIRH TSNAVEQRVK LRMADEKAGI DPGEPQDFID LFLDAKSDDV ELENNEDFTK 300
  301 AGVKVTRQLT TEEIVGQCFV FLIAGFDTTA LSLSYSSFLL ATHPKVQKKL QEEIDRECAD 360
  361 PEVTFDQLSK LKYMECVIKE TLRMYPLGAL ANSRCCMRAT KIGNYEIDEG TNILCDTWTL 420
  421 HSDKSIWGED AEEFKPERWE SGDEHFYQKG GYIPFGLGPR QCIGMRLAYM EEKLLLSHIL 480
  481 RKYTLEVCNK TQIPLKLIGS RTTQPESVWL NLTPRDDN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..518] PSI-BLAST 91.522879 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • electron carrier activity
    		•  4.64931978461551 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  4.64322346579269 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxygen binding
    		•  3.7203678182299 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • fluorene oxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • retinoic acid binding
    		•  3.04897926497756 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  2.69642243567771 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  2.69642243567771 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  2.30416050662077 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.21042366294727 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • ecdysteroid 22-hydroxylase activity
    		•  1.58167166311061 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • protein binding
    		•  0.836411857417911 bayes_pls_golite062009
  • iron ion binding
    		•  0.834040060319729 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.780604486782617 bayes_pls_golite062009
  • cation binding
    		•  0.780350495727298 bayes_pls_golite062009
  • metal ion binding
    		•  0.780350495727298 bayes_pls_golite062009
  • ion binding
    		•  0.773102216481016 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.614118857213859 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  0.377799149936808 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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