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Protein Overview: pkc-3

General Information:
Name(s) found: pkc-3 / CE02604 [WormBase]
Description(s) found:
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  • WBGene00004034 locus:pkc-3 Protein kinase C-like 3 status:Confirmed UniProt:Q19266 protein_id:CCD68754.1 [WormBase]
  • pir||T16006 protein kinase C3 - Caenorhabditis elegans [NCBI NR]
  • gi|51701751|sp|Q19266.1|KPC3_CAEEL RecName: Full=Protein kinase C-like 3; AltName: Full=Atypical protein kinase C-3; Short=aPKC3 [NCBI NR]
  • gi|2688946|gb|AAB88885.1| protein kinase C3 [Caenorhabditis elegans] [NCBI NR]
  • gi|17533011|ref|NP_495011.1| Protein Kinase C family member (pkc-3) [Caenorhabditis elegans] [NCBI NR]
  • gi|157201191|dbj|BAF80143.1| atypical protein kinase C [Caenorhabditis elegans] [NCBI NR]
  • gi|1019950|gb|AAA79341.1| Protein kinase c protein 3 [Caenorhabditis elegans] [NCBI NR]
  • (Q19266) Protein kinase C-like 3 (EC 2.7.1.37) (Atypical protein kinase C-3) (aPKC3) [Swiss-Prot]
  • Protein kinase C-like 3 OS=Caenorhabditis elegans GN=pkc-3 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE02604 WBGene00004034 locus:pkc-3 Protein kinase C status:Confirmed SW:Q19266 protein_id:AAA79341.1 [wormpep150.fasta]
  • 02604 WBGene00004034 locus:pkc-3 Protein kinase C status:Confirmed TR:Q19266 protein_id:AAA79341.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • protein kinase C, iota/lambda/zeta type, component of a PDZ-mediated protein complex PAR-6/PAR-3/PKC-3 required for establishing embryonic polarity (68.0 kD) (pkc-3) [Caenorhabditis elegans]gi|1019950|gb|AAA79341.1| Protein kinase c protein 3 [Caenorhabd [nrdb_11152004_Chlamydomonas]
  • 02604 WBGene00004034 locus:pkc-3 Protein kinase C status:Confirmed SW:Q19266 protein_id:AAA79341.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:pkc-3 Protein kinase C status:Confirmed TR:Q19266 protein_id:AAA79341.1 [wormpep115.fasta.reversed]
  • CE02604 Protein kinase C status:Confirmed TR:Q19266 protein_id:AAA79341.1 [wormpep80.hongbin]
  • CE02604 WBGene00004034 locus:pkc-3 Protein kinase C status:Confirmed UniProt:Q19266 protein_id:AAA79341.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE02604 WBGene00004034 locus:pkc-3 Protein kinase C status:Confirmed UniProt:Q19266 protein_id:AAA79341.1| [wormORF-contam.fasta]
  • Protein kinase C-like 3 (Atypical protein kinase C-3) (aPKC3) [nr-271106-contam.fasta]
  • protein kinase C3 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Protein Kinase C family member (pkc-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Protein kinase c protein 3 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE02604 WBGene00004034 locus:pkc-3 Protein kinase C status:Confirmed UniProt:Q19266 protein_id:CCD68754.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE02604 WBGene00004034 locus:pkc-3 status:Confirmed UniProt:Q19266 protein_id:CCD68754.1 Protein kinase C-like 3 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 597 amino acids

    Gene Ontology:
    Cellular Component: cell cortex [IDALink to PubMed article]
    Biological Process: negative regulation of vulval development [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPTSLEED GDIKLKTRFQ GQVVVLYARP PLILDDFFAL LKDACKQHKK QDITVKWIDE  60
   61 DGDPISIDSQ MELDEAVRCL NSSQEAELNI HVFVGKPELP GLPCQGEDKT VYRRGARRWK 120
  121 KIYLYNGHRF QAKRLNRRIQ CFICHDYIWG IGRQGFRCVD CRLCVHKKCH RHVRTHCGQA 180
  181 LQGPNIIPMA PASGSLKGAR SNTSSSTTRS GGGIDNGAFH EHEIESPGST SHDASRAMNG 240
  241 NGSSKWAVSL NDFRLLTVIG RGSYAKVVQA EHVSTRQIYA IKIIKKEMFN EDEDIDWVQT 300
  301 EKSVFEAASN YPFLVGLHSC FQTESRLFFV IEFVPGGDLM FHMQQQRKLP EEHARFYSGE 360
  361 IILALHFLHS RGIIYRDLKL DNVLIDAEGH IKLTDYGMCK ENIKDGDLTS TFCGTPNYIA 420
  421 PEILRGDEYG FSVDWWALGV LMFEMMAGRS PFDIVGMQNS EENTEDYLFQ IILERQIRIP 480
  481 RSLSVRASGI LKGFLNKDPT ERLGCKLDIN EGLRDMKEHQ FFRGFIDWEA LEQKAVAPPY 540
  541 HPAVESDRDL THFDHQFTDE LPQLSPDNPD VIARIDQSEF DGFEYVNPLQ MSREDSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..95] PSI-BLAST 22.522879 Solution Structure of the PB1 domain of PKCiota
    2 View Details [96..524] PSI-BLAST 48.30103 Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
    3 View Details [525..597] PSI-BLAST 92.30103 Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.40869571527615 bayes_pls_golite062009
  • protein kinase activity
    		•  2.33375027480966 bayes_pls_golite062009
  • kinase activity
    		•  2.3070634049589 bayes_pls_golite062009
  • binding
    		•  2.24212855645397 bayes_pls_golite062009
  • protein binding
    		•  2.09596244214119 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.07643991042071 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.93849072962936 bayes_pls_golite062009
  • signal transducer activity
    		•  1.66142358332016 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.66142358332016 bayes_pls_golite062009
  • transferase activity
    		•  1.56694652741645 bayes_pls_golite062009
  • phospholipase binding
    		•  0.746850275604721 bayes_pls_golite062009
  • kinase binding
    		•  0.452988418922855 bayes_pls_golite062009
  • protein kinase binding
    		•  0.438176837693626 bayes_pls_golite062009
  • catalytic activity
    		•  0.178906437366734 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.14527324856472 bayes_pls_golite062009
  • SH2 domain binding
    		•  3.03401803018883 bayes_pls_golite062009
  • receptor activity
    		•  2.92302133496371 bayes_pls_golite062009
  • actin binding
    		•  2.91722352767433 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.82134497010588 bayes_pls_golite062009
  • signal transducer activity
    		•  2.82134497010588 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • vinculin binding
    		•  2.81520439694489 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  2.11611043663195 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  2.11611043663195 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • insulin binding
    		•  2.0719180171079 bayes_pls_golite062009
  • tau-protein kinase activity
    		•  2.00481226596005 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  1.92111648893005 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.88428037554272 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • actin filament binding
    		•  1.75933904320288 bayes_pls_golite062009
  • MAP kinase kinase kinase kinase activity
    		•  1.70795227184717 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.32196787649813 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.24312972088703 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • activin binding
    		•  1.17357465780187 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.11664317075762 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • PTB domain binding
    		•  1.09159018564123 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  1.03150090191995 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.950774777422509 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.828948654336299 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.767275562047313 bayes_pls_golite062009
  • activin receptor activity
    		•  0.759766561351959 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.657156113273289 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.568332175782799 bayes_pls_golite062009
  • peptide binding
    		•  0.532669337315477 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • myosin binding
    		•  0.259936573810332 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  0.0667996033448706 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle