YRC Public Data Repository - Protein Structure Prediction

Protein:	pkc-3
Organism:	Caenorhabditis elegans
Length:	597 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pkc-3.

Description	E-value	Query Range	Subject Range
gi\|33303765, gi\|... - gi\|60652873\|gb\|AAX29131.1\| protein kinase C zeta [synthetic construct], gi\|33303765\|gb\|AAQ02396.1\| p...	502.0	[0..2]	[597..5]

Back

Predicted Domain #1

Region A:
Residues: [1-95]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPTSLEED GDIKLKTRFQ GQVVVLYARP PLILDDFFAL LKDACKQHKK QDITVKWIDE  60
   61 DGDPISIDSQ MELDEAVRCL NSSQEAELNI HVFVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.522879
Match:	1vd2A
Description:	Solution Structure of the PB1 domain of PKCiota
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	2.40869571527615	bayes_pls_golite062009
protein kinase activity	2.33375027480966	bayes_pls_golite062009
kinase activity	2.3070634049589	bayes_pls_golite062009
binding	2.24212855645397	bayes_pls_golite062009
protein binding	2.09596244214119	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.07643991042071	bayes_pls_golite062009
protein serine/threonine kinase activity	1.93849072962936	bayes_pls_golite062009
signal transducer activity	1.66142358332016	bayes_pls_golite062009
molecular transducer activity	1.66142358332016	bayes_pls_golite062009
transferase activity	1.56694652741645	bayes_pls_golite062009
phospholipase binding	0.746850275604721	bayes_pls_golite062009
kinase binding	0.452988418922855	bayes_pls_golite062009
protein kinase binding	0.438176837693626	bayes_pls_golite062009
catalytic activity	0.178906437366734	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [96-524]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPELPGLPCQ GEDKTVYRRG ARRWKKIYLY NGHRFQAKRL NRRIQCFICH DYIWGIGRQG  60
   61 FRCVDCRLCV HKKCHRHVRT HCGQALQGPN IIPMAPASGS LKGARSNTSS STTRSGGGID 120
  121 NGAFHEHEIE SPGSTSHDAS RAMNGNGSSK WAVSLNDFRL LTVIGRGSYA KVVQAEHVST 180
  181 RQIYAIKIIK KEMFNEDEDI DWVQTEKSVF EAASNYPFLV GLHSCFQTES RLFFVIEFVP 240
  241 GGDLMFHMQQ QRKLPEEHAR FYSGEIILAL HFLHSRGIIY RDLKLDNVLI DAEGHIKLTD 300
  301 YGMCKENIKD GDLTSTFCGT PNYIAPEILR GDEYGFSVDW WALGVLMFEM MAGRSPFDIV 360
  361 GMQNSEENTE DYLFQIILER QIRIPRSLSV RASGILKGFL NKDPTERLGC KLDINEGLRD 420
  421 MKEHQFFRG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.30103
Match:	1opkA
Description:	Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity	4.97855712164511	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cAMP-dependent protein kinase activity	4.66277812893755	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
phosphoinositide 3-kinase binding	3.43994026029707	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	3.41480681854114	bayes_pls_golite062009
transmembrane receptor protein kinase activity	3.40140621607334	bayes_pls_golite062009
transmembrane receptor activity	3.14527324856472	bayes_pls_golite062009
SH2 domain binding	3.03401803018883	bayes_pls_golite062009
receptor activity	2.92302133496371	bayes_pls_golite062009
actin binding	2.91722352767433	bayes_pls_golite062009
molecular transducer activity	2.82134497010588	bayes_pls_golite062009
signal transducer activity	2.82134497010588	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
vinculin binding	2.81520439694489	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
transforming growth factor beta receptor activity	2.11611043663195	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	2.11611043663195	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
insulin binding	2.0719180171079	bayes_pls_golite062009
tau-protein kinase activity	2.00481226596005	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
JUN kinase kinase kinase kinase activity	1.92111648893005	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
actin-dependent ATPase activity	1.88428037554272	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
acetylcholine receptor activator activity	1.83545227594542	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
actin filament binding	1.75933904320288	bayes_pls_golite062009
MAP kinase kinase kinase kinase activity	1.70795227184717	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
growth factor binding	1.53863828216563	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
insulin receptor activity	1.32196787649813	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
ErbB-3 class receptor binding	1.25765701903393	bayes_pls_golite062009
epidermal growth factor receptor binding	1.24312972088703	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
activin binding	1.17357465780187	bayes_pls_golite062009
nucleic acid binding	1.16049201286103	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity	1.11664317075762	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
PTB domain binding	1.09159018564123	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity	1.03150090191995	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.950774777422509	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.872782211382796	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.828948654336299	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
structural constituent of muscle	0.767275562047313	bayes_pls_golite062009
activin receptor activity	0.759766561351959	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.75189004129952	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
ErbB-2 class receptor binding	0.657156113273289	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
transcription repressor activity	0.568332175782799	bayes_pls_golite062009
peptide binding	0.532669337315477	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
3-phosphoinositide-dependent protein kinase binding	0.372842462336059	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
myosin binding	0.259936573810332	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
activin receptor activity, type I	0.0667996033448706	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [525-597]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIDWEALEQK AVAPPYHPAV ESDRDLTHFD HQFTDELPQL SPDNPDVIAR IDQSEFDGFE  60
   61 YVNPLQMSRE DSV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.30103
Match:	1zrzA
Description:	Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: