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Protein Overview: cdc7

General Information:
Name(s) found: cdc7 / SPBC21.06c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • serine/threonine protein kinase Cdc7 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1062 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    Biological Process: protein amino acid phosphorylation [IMPLink to PubMed article]
    septation initiation signaling [IGILink to PubMed article]
    Molecular Function: magnesium ion binding [IEA]
    ATP binding [IEA]
    protein binding [IPILink to PubMed article]
    protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHNIQASSIT LGDCLGKGAF GAVYRGLNIK NGETVAVKKV KLSKMLKSDL SVIKMEIDLL  60
   61 KNLDHPNIVK YRGSYQTNDS LCIILEYCEN GSLRSICKNF GKIPENLVAL YTFQVLQGLL 120
  121 YLHNQGVIHR DIKGANILTT KDGTIKLADF GVATKINALE DHSVVGSPYW MAPEVIELVG 180
  181 ATTASDIWSV GCTVIELLDG NPPYYDLDPT SALFRMVKDE HPPLPSNISS AAKSFLMQCF 240
  241 QKDPNLRIKT RKLLKHPWVI MNQTSSKFSD AIDEVQKYNE RVKESTLTAI IEPTSNRINP 300
  301 TLHSGRQSSY HMPESPKTPI AESPDHDNWD NEFQGTLKIS DDVLKKSEHF MDFCSNFKGK 360
  361 NNSSSITSSP SKSRHAFNSD QISESNNFNA SPLSTPLKAQ FDPSKPALNR SIDHQKTPQH 420
  421 KRYLSTEFKE NIPDGIEKFV ETPRDSEFTD IFPTSSIKVQ GLRKETGLGT LVLNKCYGSW 480
  481 NNEENEDGEE SDIFDSIETN LENLDIENNI ALDKRTHLAS LLSSLLGSLR DKNIGSKDTT 540
  541 VSQIASILSE DLSLKREIIQ AHGILPLLET LREIKTPDVQ LLLLKLINTV AFDDHTTLQK 600
  601 VCFAGGLPLM LSFSNREHSF EFRYESAIFI QQMYRTSALT LQMFLSSNGL NSLLLFIKED 660
  661 YGTNRDFVFV GVEGIWKLLR QQDYIPKNDI CTMVVNDSLE PLTKAMLKAL ATDDDSSRMS 720
  721 LTRICEILLA LSQADNYVKE SLLCESALRR ILRILLYLPH SDMAITLQFF KQLSMVPSSL 780
  781 SLLRKVHIIP LLTHILGDSK IEKGRKEIRS EALAALFNVC KLDKKSQEEA VISGAIPLLQ 840
  841 EVIIKDRLFK EFALPILLAL PQAGPVSRIY LWQNKCLDFF LSLLSDLNWQ SAVFDTIASW 900
  901 LQFELREVQR VLAEKRNVQL VLKVFCISQS ASSNRMLDTL GRVCQISPRL AASYGQPIIF 960
  961 QKFKEKLTHK GTKPIVVLNI FQIMKSMCEA SSQSVAYIAH CGLPDVVANL NQTSDSVLVK1020
 1021 ELAKDLLKYL KVPQGPINEH KSPISKPHMP PPRWQPKQPL TQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..386] PSI-BLAST 79.522879 Pkb kinase
    2 View Details [387..1062] FFAS03 5.01 Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.79505438761262 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.93176092222748 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.90354666768303 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.71452519680794 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.28428643482914 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.27184436658773 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.22442673174261 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.22172815474021 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • insulin binding
    		•  0.614254468447749 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • tubulin binding
    		•  0.525721160726465 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • actin binding
    		•  0.456340967230669 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • telethonin binding
    		•  0.386946764759301 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.267404531445803 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • cation channel activity
    		•  0.245400615103891 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • microtubule binding
    		•  0.191960933574742 bayes_pls_golite062009
  • protein complex binding
    		•  0.132247221889251 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.96084803796407 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.69616509670156 bayes_pls_golite062009
  • protein transporter activity
    		•  2.6734690782599 bayes_pls_golite062009
  • protein binding
    		•  2.66176697577398 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.31364900991203 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.19067997822967 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.04102668570108 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.01138880938179 bayes_pls_golite062009
  • DNA binding
    		•  1.96172460362671 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.89164579147193 bayes_pls_golite062009
  • transporter activity
    		•  1.85346023606579 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.67265990792668 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.63680776259613 bayes_pls_golite062009
  • kinase activity
    		•  1.62528599136223 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.55513633605739 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.52026598954455 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.51565516399356 bayes_pls_golite062009
  • transcription activator activity
    		•  1.47146260606784 bayes_pls_golite062009
  • protein kinase activity
    		•  1.40981221970766 bayes_pls_golite062009
  • transferase activity
    		•  1.27106937966316 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.23631920875036 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21493607378314 bayes_pls_golite062009
  • actin binding
    		•  0.864076688656138 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.824035252349223 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.710528717985301 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.647706371567682 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.632985761187158 bayes_pls_golite062009
  • protein phosphatase type 2A regulator activity
    		•  0.500648596452028 bayes_pls_golite062009
  • structural molecule activity
    		•  0.439909304123455 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.333600669648793 bayes_pls_golite062009
  • RNA binding
    		•  0.243875756041061 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.109435859778099 bayes_pls_golite062009
  • clathrin binding
    		•  0.0923079381755934 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.0831993958662147 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0728493557966827 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0641324729536009 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0615190129942244 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.0342115143082778 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.0272200107208467 bayes_pls_golite062009
  • transcription factor binding
    		•  8.79739237675814E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle