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Protein Overview: CalpC-PA

General Information:
Name(s) found: CalpC-PA / FBpp0074005 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Calpain C is referred to in FlyBase by the symbol Dmel\CalpC (CG3692, FBgn0260450). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16219802..16222560. It has the cytological map location 14B13. It is reported to have molecular function</span>: calcium-dependent cysteine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 681 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    intracellular [IEA]
    Biological Process: proteolysis [IEA][NAS]
    Molecular Function: calcium ion binding [IEA]
    [NOT]calcium-dependent cysteine-type endopeptidase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASKYERILS DCRSKNVLWE DPDFPAVQSS VFYYQTPPFT FQWKRIMDLA DSGSGAVAAN  60
   61 SSAAPVFLNE SAEFDVVPGK MGDRWLVSCL GLLSSLRNLF YRVVPADQTL ASAHGVFRFR 120
  121 LWWCGEWVEV LVDDRLPTIN GRLAFMQPQA SNCFWAALLE KAIAKLHGSY EALKYGTRSD 180
  181 GLTDLLGGVV RQMPILSDNI RPQTLKELLT TTCIVTCLAD KSATVAKKNL AERMPNGILV 240
  241 NVNYRLSSLD KVKTLMGDSV QLVCLKDTFS SKPFGEKTHF LGDWSPMSKT WERVSQVERA 300
  301 RLIRQLGPGE FWLSFCDFVE IFSTMEVVYL DTETSNDEEM LKSRPLHWKM KMHQGQWKRG 360
  361 VTAGGCRNHE SFHINPQLLI SVQDEQDLVI ALNQHTAVEP KVIGFTMYTW DGEYMLSECL 420
  421 QKDFFKNHVS YLNSDYGNTR HVSYHTHLEA GHYVLIPTTY EPAEEAHFTV RILGTGSFRL 480
  481 SCLETQTMIL LDPFPALKST DAERCGGPKV KSVCQYEPVY MQLADENKTI NCFELHELLE 540
  541 ACLPNDYIKG CANIDICRQV IALQDRSGSG RITFQQFKTF MVNLKSWQGV FKMYTKEKAG 600
  601 ILRAERLRDA LCDIGFQLST DIMNCLIQRY IRKDGTLRLS DFVSAVIHLT TAFNQFHLKN 660
  661 YGQVNVIEVH LHDWIKSILS C

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..681] PSI-BLAST 165.0 Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural constituent of muscle
    		•  6.34041234021534 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  4.20811099622311 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.95815414384 bayes_pls_golite062009
  • peptidase activity
    		•  3.19059336788201 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.91734319991078 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43328552376748 bayes_pls_golite062009
  • troponin T binding
    		•  2.39237700612893 bayes_pls_golite062009
  • myosin II heavy chain binding
    		•  2.30950552746179 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.29802198409541 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.28098452079347 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.16689842778043 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • protein binding
    		•  1.92445772322782 bayes_pls_golite062009
  • binding
    		•  1.92046698500094 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.74951443813569 bayes_pls_golite062009
  • transporter activity
    		•  1.21845572420504 bayes_pls_golite062009
  • actin binding
    		•  1.1967948958876 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19670958990587 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11706264292297 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11706264292297 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.07520173658976 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.00091316610003 bayes_pls_golite062009
  • nitric-oxide synthase binding
    		•  0.965098383344279 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.952536088972875 bayes_pls_golite062009
  • cation channel activity
    		•  0.856991182112951 bayes_pls_golite062009
  • calcium ion binding
    		•  0.687204894708051 bayes_pls_golite062009
  • motor activity
    		•  0.68020805045422 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.654911807161532 bayes_pls_golite062009
  • DNA binding
    		•  0.561772300480686 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.515693296786409 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.495368836247989 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.484449686814032 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.366129174039334 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.341357838238159 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.308919475701377 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.304496519713588 bayes_pls_golite062009
  • potassium channel activity
    		•  0.260530997378698 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.193338880082314 bayes_pls_golite062009
  • gated channel activity
    		•  0.175191914660841 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  0.170792976663713 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.157059988605635 bayes_pls_golite062009
  • tubulin binding
    		•  0.11107511867058 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.0711800677928949 bayes_pls_golite062009
  • channel activity
    		•  0.0711800677928949 bayes_pls_golite062009
  • protein complex binding
    		•  0.0676093357928913 bayes_pls_golite062009
  • ion channel activity
    		•  0.0166394982861724 bayes_pls_golite062009
  • transcription factor activity
    		•  0.00805573746748856 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle