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Protein Overview: CkIalpha-PB, FBp...

General Information:
Name(s) found: FBpp0311373 [FlyBase]
FBpp0311372 [FlyBase]
FBpp0309354 [FlyBase]
CkIalpha-PD / FBpp0289609 [FlyBase]
CkIalpha-PA / FBpp0073515 [FlyBase]
CkIalpha-PB / FBpp0073513 [FlyBase]
Description(s) found:
Found 74 descriptions.
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  • type=protein; loc=X:join(12549271..12549349,12549411..12550185,12550367..12550526); ID=FBpp0311373; name=CkIalpha-PG; parent=FBgn0015024,FBtr0345163; dbxref=FlyBase:FBpp0311373,FlyBase_Annotation_IDs:CG2028-PG; MD5=813ec1f06c30bf507c63b29c590893e9; length=337; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:join(12549271..12549349,12549411..12550185,12550367..12550526); ID=FBpp0311372; name=CkIalpha-PF; parent=FBgn0015024,FBtr0345162; dbxref=FlyBase:FBpp0311372,FlyBase_Annotation_IDs:CG2028-PF; MD5=813ec1f06c30bf507c63b29c590893e9; length=337; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:join(12549271..12549349,12549411..12550185,12550367..12550526); ID=FBpp0309354; name=CkIalpha-PE; parent=FBgn0015024,FBtr0340408; dbxref=FlyBase:FBpp0309354,FlyBase_Annotation_IDs:CG2028-PE; MD5=813ec1f06c30bf507c63b29c590893e9; length=337; release=r5.56; species=Dmel; [FlyBase]
  • The gene Casein kinase IÃ?&#142;Ã?± is referred to in FlyBase by the symbol Dmel\CkIÃ?&#142;Ã?± (CG2028, FBgn0015024). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12547816..12551354. It has the cytological map location 11B7. There is experimental evidence that it has the molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: inter-male aggressive behavior; regulation of Wnt receptor signaling pathway; DNA repair; protein amino acid phosphorylation; negative regulation of smoothened signaling pathway; phagocytosis, engulfment. 25 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; ventral nerve cord commissure; eye; embryonic epidermis; longitudinal connective. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Casein kinase IÃ?&#142;Ã?± is referred to in FlyBase by the symbol Dmel\CkIÃ?&#142;Ã?± (CG2028, FBgn0015024). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12547816..12551354. It has the cytological map location 11B7. There is experimental evidence that it has the molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: inter-male aggressive behavior; regulation of Wnt receptor signaling pathway; DNA repair; protein amino acid phosphorylation; negative regulation of smoothened signaling pathway; phagocytosis, engulfment. 25 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; ventral nerve cord commissure; eye; embryonic epidermis; longitudinal connective. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Casein kinase IÃ?&#142;Ã?± is referred to in FlyBase by the symbol Dmel\CkIÃ?&#142;Ã?± (CG2028, FBgn0015024). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12547816..12551354. It has the cytological map location 11B7. There is experimental evidence that it has the molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: inter-male aggressive behavior; regulation of Wnt receptor signaling pathway; DNA repair; protein amino acid phosphorylation; negative regulation of smoothened signaling pathway; phagocytosis, engulfment. 25 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; ventral nerve cord commissure; eye; embryonic epidermis; longitudinal connective. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 337 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA][NAS]
    Biological Process: DNA repair [IDA]
    phagocytosis, engulfment [IMP]
    protein catabolic process [NAS]
    regulation of proteolysis [TAS]
    smoothened signaling pathway [TAS]
    Wnt receptor signaling pathway [TAS]
    regulation of Wnt receptor signaling pathway [IMP]
    protein amino acid phosphorylation [IDA][NAS]
    inter-male aggressive behavior [IMP]
    negative regulation of smoothened signaling pathway [IMP]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [IDA]
    protein serine/threonine kinase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKMRILKES RPEIIVGGKY RVIRKIGSGS FGDIYLGMSI QSGEEVAIKM ESAHARHPQL  60
   61 LYEAKLYRIL SGGVGFPRIR HHGKEKNFNT LVMDLLGPSL EDLFNFCTRH FTIKTVLMLV 120
  121 DQMIGRLEYI HLKCFIHRDI KPDNFLMGIG RHCNKLFLID FGLAKKFRDP HTRHHIVYRE 180
  181 DKNLTGTARY ASINAHLGIE QSRRDDMESL GYVMMYFNRG VLPWQGMKAN TKQQKYEKIS 240
  241 EKKMSTPIEV LCKGSPAEFS MYLNYCRSLR FEEQPDYMYL RQLFRILFRT LNHQYDYIYD 300
  301 WTMLKQKTHQ GQPNPAILLE QLDKDKEKQN GKPLIAD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..337] PSI-BLAST 62.30103 Casein kinase-1, CK1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.913893847407112 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.821371946077904 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.794058505655489 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.775404673285876 bayes_pls_golite062009
  • receptor activity
    		•  0.775180603313375 bayes_pls_golite062009
  • DNA binding
    		•  0.714163549867672 bayes_pls_golite062009
  • transcription factor activity
    		•  0.563262875317016 bayes_pls_golite062009
  • peptidase activity
    		•  0.540289770145252 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.461392047923247 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.265003282584135 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.26024936404169 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.0795689006739899 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle