Protein Overview: hh-PB

General Information:
Name(s) found:	hh-PB / FBpp0099945 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|85725250\|ref\|NP_001034065.1\| hedgehog, isoform B [Drosophila melanogaster] [NCBI NR] gi\|84796187\|gb\|ABC66186.1\| hedgehog, isoform B [Drosophila melanogaster] [NCBI NR] gi\|7300964\|gb\|AAF56102.1\| hedgehog, isoform A [Drosophila melanogaster] [NCBI NR] pir\|\|A46400 segment polarity protein hedgehog - fruit fly (Drosophila melanogaster) [NCBI NR] gi\|24649223\|ref\|NP_524459.2\| hedgehog, isoform A [Drosophila melanogaster] [NCBI NR] gi\|157610\|gb\|AAA16458.1\| hedgehog protein [Drosophila melanogaster] [NCBI NR] Protein hedgehog OS=Drosophila melanogaster GN=hh PE=1 SV=4 [Swiss-Prot] The gene hedgehog is referred to in FlyBase by the symbol Dmel\hh (CG4637, FBgn0004644). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18953425..18967881. It has the cytological map location 94E1. There is experimental evidence that it has the molecular function</span>: cell surface binding; protein binding. There is experimental evidence for 24 unique biological process</span> terms, many of which group under: anatomical structure development; cellular component movement; organ morphogenesis; regulation of biological process; sensory organ development; reproductive process in a multicellular organism; organ development; regulation of protein transport; cell projection organization; open tracheal system development; central nervous system development. 169 alleles are reported. The phenotypes of these alleles are annotated with 190 unique terms, many of which group under: organ system; adult segment; adult mesothoracic segment; peripheral nervous system; primordium; nervous system; embryonic nervous system; late extended germ band embryo; ventral nerve cord primordium; abdominal ventral denticle belt. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG4637-PA translation from_gene[CG4637 hh FBgn0004644] seq_release:3 mol_weight=52151 cds_boundaries:(3R:18,945,119..18,957,900[-]) aa_length:471 transcript_info:[CG4637-RA seq_release:3] gene_info:[gene symbol:hh FBgn0004644 gene_boundaries:(3R:18,94 [hmr_yeast5_DM3-1_pombe.fasta] (AE003742) hh gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG4637-PA [Drosophila melanogaster]gi\|24649223\|ref\|NP_524459.2\| CG4637-PA [Drosophila melanogaster]gi\|542580\|pir\|\|A46400 segment polarity protein hedgehog - fruit fly (Drosophila melanogaster)gi\|435849\|gb\|AAB28646.1\| segment polarity gene hedgehog [Dro [nrdb_11152004_Chlamydomonas] type=protein; loc=3R:complement(18954460..18955133,18958724..18958985,18966764..18967243); ID=FBpp0083796; name=hh-PA; parent=FBgn0004644,FBtr0084404; dbxref=FlyBase_Annotation_IDs:CG4637-PA,FlyBase:FBpp0083796,GB_protein:AAF56102.1,REFSEQ:NP_524459,GB_pr [fly-100309-contam.fasta] type=protein; loc=3R:complement(18954460..18955133,18958724..18958985,18966764..18967243); ID=FBpp0099945; name=hh-PB; parent=FBgn0004644,FBtr0100506; dbxref=FlyBase_Annotation_IDs:CG4637-PB,FlyBase:FBpp0099945,GB_protein:ABC66186.1,REFSEQ:NP_001034065,GB [fly-100309-contam.fasta] CG4637-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] CG4637-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] hedgehog protein [nr-271106-contam.fasta] hedgehog CG4637-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] hedgehog CG4637-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3R:complement(18954460..18955133,18958724..18958985,18966764..18967243); ID=FBpp0083796; name=hh-PA; parent=FBgn0004644,FBtr0084404; dbxref=FlyBase_Annotation_IDs:CG4637-PA,FlyBase:FBpp0083796,GB_protein:AAF56102.1,REFSEQ:NP_524459,GB_protein:AAF56102; MD5=5c191b66187eb54dff3620f7f83f9753; length=471; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:complement(18954460..18955133,18958724..18958985,18966764..18967243); ID=FBpp0099945; name=hh-PB; parent=FBgn0004644,FBtr0100506; dbxref=FlyBase_Annotation_IDs:CG4637-PB,FlyBase:FBpp0099945,GB_protein:ABC66186.1,REFSEQ:NP_001034065,GB_protein:ABC66186; MD5=5c191b66187eb54dff3620f7f83f9753; length=471; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:complement(18954460..18955133,18958724..18958985,18966764..18967243); ID=FBpp0083796; name=hh-PA; parent=FBgn0004644,FBtr0084404; dbxref=FlyBase_Annotation_IDs:CG4637-PA,FlyBase:FBpp0083796,GB_protein:AAF56102.1,REFSEQ:NP_524459,GB_protein:AAF56102; MD5=5c191b66187eb54dff3620f7f83f9753; length=471; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3R:complement(18954460..18955133,18958724..18958985,18966764..18967243); ID=FBpp0099945; name=hh-PB; parent=FBgn0004644,FBtr0100506; dbxref=FlyBase_Annotation_IDs:CG4637-PB,FlyBase:FBpp0099945,GB_protein:ABC66186.1,REFSEQ:NP_001034065,GB_protein:ABC66186; MD5=5c191b66187eb54dff3620f7f83f9753; length=471; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3R:complement(18954460..18955133,18958724..18958985,18966764..18967243); ID=FBpp0099945; name=hh-PB; parent=FBgn0004644,FBtr0100506; dbxref=FlyBase_Annotation_IDs:CG4637-PB,FlyBase:FBpp0099945,GB_protein:ABC66186.1,REFSEQ:NP_001034065,GB_protein:ABC66186,FlyMine:FBpp0099945,modMine:FBpp0099945; MD5=5c191b66187eb54dff3620f7f83f9753; length=471; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3R:complement(join(23141042..23141521,23133002..23133263,23128738..23129411)); ID=FBpp0099945; name=hh-PB; parent=FBgn0004644,FBtr0100506; dbxref=FlyBase_Annotation_IDs:CG4637-PB,FlyBase:FBpp0099945,GB_protein:ABC66186.1,REFSEQ:NP_001034065,GB_protein:ABC66186,FlyMine:FBpp0099945,modMine:FBpp0099945; MD5=5c191b66187eb54dff3620f7f83f9753; length=471; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3R:complement(join(23141042..23141521,23133002..23133263,23128738..23129411)); ID=FBpp0099945; name=hh-PB; parent=FBgn0004644,FBtr0100506; dbxref=FlyBase_Annotation_IDs:CG4637-PB,FlyBase:FBpp0099945,GB_protein:ABC66186.1,REFSEQ:NP_001034065,GB_protein:ABC66186,FlyMine:FBpp0099945,modMine:FBpp0099945; MD5=5c191b66187eb54dff3620f7f83f9753; length=471; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0099945 type=protein; loc=3R:complement(join(23141042..23141521,23133002..23133263,23128738..23129411)); ID=FBpp0099945; name=hh-PB; parent=FBgn0004644,FBtr0100506; dbxref=FlyBase_Annotation_IDs:CG4637-PB,FlyBase:FBpp0099945,GB_protein:ABC66186.1,REFSEQ:NP_001034065,GB_protein:ABC66186,FlyMine:FBpp0099945,modMine:FBpp0099945; MD5=5c191b66187eb54dff3620f7f83f9753; length=471; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3R:complement(join(23141042..23141521,23133002..23133263,23128738..23129411)); ID=FBpp0099945; name=hh-PB; parent=FBgn0004644,FBtr0100506; dbxref=FlyBase_Annotation_IDs:CG4637-PB,FlyBase:FBpp0099945,GB_protein:ABC66186.1,REFSEQ:NP_001034065,GB_protein:ABC66186,UniProt/Swiss-Prot:Q02936,FlyMine:FBpp0099945,modMine:FBpp0099945; MD5=5c191b66187eb54dff3620f7f83f9753; length=471; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	471 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS] endocytic vesicle [IDA] cytoplasm [IDA][NAS] cytoplasmic membrane-bounded vesicle [IDA] extracellular region [NAS][TAS]
Biological Process:	anterior head segmentation [TAS] posterior head segmentation [TAS] epidermis development [TAS] mesoderm development [NAS] protein splicing [TAS] progression of morphogenetic furrow during compound eye morphogenesis [IEP][IGI][IMP][TAS] glial cell migration [IMP] compound eye morphogenesis [TAS] Bolwig's organ morphogenesis [IMP] ovarian follicle cell development [TAS] morphogenesis of larval imaginal disc epithelium [IMP] cytoneme assembly [IMP] germ cell attraction [TAS] regulation of protein import into nucleus [IMP] spiracle morphogenesis, open tracheal system [IMP] anterior/posterior axis specification, embryo [NAS] cell-cell signaling [IEA] smoothened signaling pathway [IGI][NAS][TAS] regulation of organ growth [TAS] compartment pattern formation [TAS] germ cell migration [IMP] positive regulation of hh target transcription factor activity [IGI] growth [NAS] regulation of mitotic cell cycle [IMP] open tracheal system development [TAS] compound eye photoreceptor cell differentiation [TAS] ventral midline development [IMP] anterior/posterior lineage restriction, imaginal disc [TAS] R8 cell fate specification [NAS] genital disc anterior/posterior pattern formation [IEP] wing disc proximal/distal pattern formation [TAS] germ-line stem cell division [TAS] imaginal disc-derived wing vein specification [TAS] positive regulation of transcription factor import into nucleus [IMP] ectoderm development [NAS] leg disc morphogenesis [TAS] gonadal mesoderm development [IMP] wing disc anterior/posterior pattern formation [TAS] heart development [NAS][TAS] developmental pigmentation [TAS] epithelial cell migration, open tracheal system [IMP] somatic stem cell division [TAS] labial disc development [IMP] genital disc development [IMP][TAS] pole cell migration [IGI] intein-mediated protein splicing [IEA] foregut morphogenesis [TAS] analia development [TAS] segment polarity determination [IEP][IMP][NAS][TAS] trunk segmentation [TAS] hindgut morphogenesis [IMP][TAS] imaginal disc pattern formation [NAS] regulation of cell proliferation [NAS] anterior commissure morphogenesis [IMP] regulation of transcription from RNA polymerase II promoter [TAS] imaginal disc growth [TAS] ovarian follicle cell stalk formation [TAS] eye morphogenesis [IMP] positive regulation of smoothened signaling pathway [TAS] proteolysis [IEA] protein autoprocessing [IDA][IMP][NAS][TAS]
Molecular Function:	protein binding [IPI] cysteine-type endopeptidase activity [ISS] endopeptidase activity [NAS] peptidase activity [IEA] cell surface binding [IDA] patched binding [NAS][TAS] signal transducer activity [TAS] morphogen activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNHSSVPWA SAASVTCLSL DAKCHSSSSS SSSKSAASSI SAIPQEETQT MRHIAHTQRC  60
   61 LSRLTSLVAL LLIVLPMVFS PAHSCGPGRG LGRHRARNLY PLVLKQTIPN LSEYTNSASG 120
  121 PLEGVIRRDS PKFKDLVPNY NRDILFRDEE GTGADRLMSK RCKEKLNVLA YSVMNEWPGI 180
  181 RLLVTESWDE DYHHGQESLH YEGRAVTIAT SDRDQSKYGM LARLAVEAGF DWVSYVSRRH 240
  241 IYCSVKSDSS ISSHVHGCFT PESTALLESG VRKPLGELSI GDRVLSMTAN GQAVYSEVIL 300
  301 FMDRNLEQMQ NFVQLHTDGG AVLTVTPAHL VSVWQPESQK LTFVFADRIE EKNQVLVRDV 360
  361 ETGELRPQRV VKVGSVRSKG VVAPLTREGT IVVNSVAASC YAVINSQSLA HWGLAPMRLL 420
  421 STLEAWLPAK EQLHSSPKVV SSAQQQNGIH WYANALYKVK DYVLPQSWRH D

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..80]	deduced	N/A	No confident structure predictions are available.
2	View Details	[81..255]	PSI-BLAST	61.39794	No description for 2ibgE was found.
3	View Details	[256..471]	PSI-BLAST	33.522879	17-KDA FRAGMENT OF HEDGEHOG C-TERMINAL AUTOPROCESSING DOMAIN

Protein Overview: hh-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: