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View Structure Prediction Details

Protein: hh-PB
Organism: Drosophila melanogaster
Length: 471 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hh-PB.

Description E-value Query
Range
Subject
Range
gi|384220 - gi|384220|prf||1905316A hedgehog gene
590.0 [0..1] [471..1]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNHSSVPWA SAASVTCLSL DAKCHSSSSS SSSKSAASSI SAIPQEETQT MRHIAHTQRC  60
   61 LSRLTSLVAL LLIVLPMVFS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [81-255]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAHSCGPGRG LGRHRARNLY PLVLKQTIPN LSEYTNSASG PLEGVIRRDS PKFKDLVPNY  60
   61 NRDILFRDEE GTGADRLMSK RCKEKLNVLA YSVMNEWPGI RLLVTESWDE DYHHGQESLH 120
  121 YEGRAVTIAT SDRDQSKYGM LARLAVEAGF DWVSYVSRRH IYCSVKSDSS ISSHV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.39794
Match: 2ibgE
Description: No description for 2ibgE was found.

Predicted Domain #3
Region A:
Residues: [256-471]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGCFTPESTA LLESGVRKPL GELSIGDRVL SMTANGQAVY SEVILFMDRN LEQMQNFVQL  60
   61 HTDGGAVLTV TPAHLVSVWQ PESQKLTFVF ADRIEEKNQV LVRDVETGEL RPQRVVKVGS 120
  121 VRSKGVVAPL TREGTIVVNS VAASCYAVIN SQSLAHWGLA PMRLLSTLEA WLPAKEQLHS 180
  181 SPKVVSSAQQ QNGIHWYANA LYKVKDYVLP QSWRHD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.522879
Match: 1at0A
Description: 17-KDA FRAGMENT OF HEDGEHOG C-TERMINAL AUTOPROCESSING DOMAIN
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle