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Protein Overview: spn-E-PA

General Information:
Name(s) found: spn-E-PA / FBpp0082637 [FlyBase]
Description(s) found:
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  • gi|7300065|gb|AAF55235.1| spindle E [Drosophila melanogaster] [NCBI NR]
  • gi|17136508|ref|NP_476741.1| spindle E [Drosophila melanogaster] [NCBI NR]
  • Probable ATP-dependent RNA helicase spindle-E OS=Drosophila melanogaster GN=spn-E PE=2 SV=1 [Swiss-Prot]
  • The gene spindle E is referred to in FlyBase by the symbol Dmel\spn-E (CG3158, FBgn0003483). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11663159..11670138. It has the cytological map location 89A5. Based on sequence similarity, it is predicted to have molecular function</span>: helicase activity; ATP-dependent RNA helicase activity. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; anatomical structure development; anterior/posterior axis specification; regulation of metabolic process; cellular macromolecular complex subunit organization; regulation of developmental process; dorsal/ventral axis specification; negative regulation of gene expression, epigenetic; multicellular organism reproduction; negative regulation of cellular biosynthetic process; karyosome formation; regulation of cell morphogenesis; polarity specification of dorsal/ventral axis. 29 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; oocyte; karyosome; nuage; spermatocyte; egg chamber; microtubule; dorsal appendage; synaptonemal complex. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG3158-PA translation from_gene[CG3158 spn-E FBgn0003483] seq_release:3 mol_weight=164512 cds_boundaries:(3R:11,663,223..11,669,843[+]) aa_length:1434 transcript_info:[CG3158-RA seq_release:3] gene_info:[gene symbol:spn-E FBgn0003483 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VF26) SPN-E protein [DrosMelano7227.FASTAC.txt]
  • (AE003710) spn-E gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG3158-PA [Drosophila melanogaster]gi|17136508|ref|NP_476741.1| CG3158-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(11663205..11663402,11663460..11663702,11665421..11666154,11666252..11666904,11666994..11667127,11667179..11667768,11667825..11667972,11668040..11669176,11669237..11669358,11669420..11669632,11669696..11669828); ID=FBpp0082637; na [fly-100309-contam.fasta]
  • CG3158-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • spindle E CG3158-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(11663205..11663402,11663460..11663702,11665421..11666154,11666252..11666904,11666994..11667127,11667179..11667768,11667825..11667972,11668040..11669176,11669237..11669358,11669420..11669632,11669696..11669828); ID=FBpp0082637; name=spn-E-PA; parent=FBgn0003483,FBtr0083183; dbxref=FlyBase:FBpp0082637,FlyBase_Annotation_IDs:CG3158-PA,GB_protein:AAF55235.1,REFSEQ:NP_476741,GB_protein:AAF55235; MD5=aec738c5f73d2854b3a1b777cdaaa967; length=1434; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(11663205..11663402,11663460..11663702,11665421..11666154,11666252..11666904,11666994..11667127,11667179..11667768,11667825..11667972,11668040..11669176,11669237..11669358,11669420..11669632,11669696..11669828); ID=FBpp0082637; name=spn-E-PA; parent=FBgn0003483,FBtr0083183; dbxref=FlyBase:FBpp0082637,FlyBase_Annotation_IDs:CG3158-PA,GB_protein:AAF55235.1,REFSEQ:NP_476741,GB_protein:AAF55235; MD5=aec738c5f73d2854b3a1b777cdaaa967; length=1434; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(11663205..11663402,11663460..11663702,11665421..11666154,11666252..11666904,11666994..11667127,11667179..11667768,11667825..11667972,11668040..11669176,11669237..11669358,11669420..11669632,11669696..11669828); ID=FBpp0082637; name=spn-E-PA; parent=FBgn0003483,FBtr0083183; dbxref=FlyBase:FBpp0082637,FlyBase_Annotation_IDs:CG3158-PA,GB_protein:AAF55235.1,REFSEQ:NP_476741,GB_protein:AAF55235,FlyMine:FBpp0082637,modMine:FBpp0082637; MD5=aec738c5f73d2854b3a1b777cdaaa967; length=1434; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(15837483..15837680,15837738..15837980,15839699..15840432,15840530..15841182,15841272..15841405,15841457..15842046,15842103..15842250,15842318..15843454,15843515..15843636,15843698..15843910,15843974..15844106); ID=FBpp0082637; name=spn-E-PA; parent=FBgn0003483,FBtr0083183; dbxref=FlyBase:FBpp0082637,FlyBase_Annotation_IDs:CG3158-PA,GB_protein:AAF55235.1,REFSEQ:NP_476741,GB_protein:AAF55235,FlyMine:FBpp0082637,modMine:FBpp0082637; MD5=aec738c5f73d2854b3a1b777cdaaa967; length=1434; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(15837483..15837680,15837738..15837980,15839699..15840432,15840530..15841182,15841272..15841405,15841457..15842046,15842103..15842250,15842318..15843454,15843515..15843636,15843698..15843910,15843974..15844106); ID=FBpp0082637; name=spn-E-PA; parent=FBgn0003483,FBtr0083183; dbxref=FlyBase:FBpp0082637,FlyBase_Annotation_IDs:CG3158-PA,GB_protein:AAF55235.1,REFSEQ:NP_476741,GB_protein:AAF55235,FlyMine:FBpp0082637,modMine:FBpp0082637; MD5=aec738c5f73d2854b3a1b777cdaaa967; length=1434; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0082637 type=protein; loc=3R:join(15837483..15837680,15837738..15837980,15839699..15840432,15840530..15841182,15841272..15841405,15841457..15842046,15842103..15842250,15842318..15843454,15843515..15843636,15843698..15843910,15843974..15844106); ID=FBpp0082637; name=spn-E-PA; parent=FBgn0003483,FBtr0083183; dbxref=FlyBase:FBpp0082637,FlyBase_Annotation_IDs:CG3158-PA,GB_protein:AAF55235.1,REFSEQ:NP_476741,GB_protein:AAF55235,FlyMine:FBpp0082637,modMine:FBpp0082637; MD5=aec738c5f73d2854b3a1b777cdaaa967; length=1434; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(15837483..15837680,15837738..15837980,15839699..15840432,15840530..15841182,15841272..15841405,15841457..15842046,15842103..15842250,15842318..15843454,15843515..15843636,15843698..15843910,15843974..15844106); ID=FBpp0082637; name=spn-E-PA; parent=FBgn0003483,FBtr0083183; dbxref=FlyBase:FBpp0082637,FlyBase_Annotation_IDs:CG3158-PA,GB_protein:AAF55235.1,REFSEQ:NP_476741,GB_protein:AAF55235,UniProt/Swiss-Prot:Q9VF26,FlyMine:FBpp0082637,modMine:FBpp0082637; MD5=aec738c5f73d2854b3a1b777cdaaa967; length=1434; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1434 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA][NAS]
    Biological Process: intracellular mRNA localization [IMP][TAS]
    germarium-derived oocyte fate determination [IGI]
    polarity specification of dorsal/ventral axis [IMP]
    dorsal appendage formation [IMP]
    oocyte differentiation [NAS]
    chromatin silencing [IMP]
    pole plasm assembly [NAS]
    RNA localization [TAS]
    polarity specification of anterior/posterior axis [IMP]
    regulation of pole plasm oskar mRNA localization [IMP]
    oocyte maturation [IMP]
    oogenesis [IGI][TAS]
    karyosome formation [IMP]
    pole plasm oskar mRNA localization [IMP]
    RNA interference [TAS]
    oocyte localization during germarium-derived egg chamber formation [IMP]
    targeting of mRNA for destruction involved in RNA interference [IMP]
    Molecular Function: nucleic acid binding [IEA]
    ATP binding [IEA]
    zinc ion binding [IEA]
    RNA helicase activity [TAS]
    RNA-dependent ATPase activity [TAS]
    helicase activity [ISS]
    ATP-dependent RNA helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQEVMDFFD FSKELKRVAA APQGYISSDP RLMATKFKSS EVPNRELIGT DYVSKIVAKE  60
   61 KCLLNGTLLN EQPQGKRIRT LDDLDTDDEG EETEIRRDDE YYKKFRFNLN RDKNLSIYAK 120
  121 REEILAAINA HPVVIIKGET GCGKTTQVPQ YILDEAYKSG KYCNIVVTQP RRIAAISIAN 180
  181 RVCQEREWQQ NTVCSFQVGL HRPNSLEDTR LLYCTTGVLL NNLINNKTLT HYTHIVLDEV 240
  241 HERDQNMDFL LIVVRRLLAT NSRHVKIILM SATIDAKELS DYFTTTNSIP PVITTNHRRK 300
  301 HSIEKFYRDQ LGSIIWNEED VGHQQVPEIN KHGYRAAVKI IVIIDNMERK AAIQSRQSYD 360
  361 EALRYGAVLI FLPGIYEIDT MAENLTCMLE NDPNIKVSIV RCFSLMTPEN QRDVFNPPPP 420
  421 GFRKIILTTN IAESSITVPD VSYVIDFCLA KVKVTDTASS FSSLRLTWAS KANCRQRAGR 480
  481 VGRLRSGRVY RMVNKHFYQR EMPEFGIPEM LRLPLQNSVL KAKVLNMGSP VEILALALSP 540
  541 PNLSDIHNTI LLLKEVGALY LTVDGIYDPL DGDLTYWGTI MSRLPLDTRQ SRLIILGYIF 600
  601 NMLEEAIIIA AGLSTPGLFA HEGGRSQLGD SFWMHYIFSD GSGSDLVAIW RVYLTYLNIV 660
  661 ENGHDQESAI RWAKRFHVSL RSLKEIHLLV QELRVRCTHL GLIPFPVNPN QMMDDREKAI 720
  721 MLKVIIAGAF YPNYFTRSKE SCADTDRNIY QTISGHDPCR TVYFTNFKPA YMGELYTRRI 780
  781 KELFQEVRIP PENMDVTFQE GSQKVFVTFK QDDWIEGSSK YVPVSGRVQS EVYKAVMMRQ 840
  841 NRVERPIHIM NPSAFMSYVQ QRGIGDVIEG RWIPPTKPLN VELLALPSVF DKTISGSITC 900
  901 IVNCGKFFFQ PQSFEECIRN MSEIFNAPQQ LRNYVTNASA IAKGMMVLAK RDSYFQRATV 960
  961 IRPENQSNRQ PMFYVRFIDY GNCTLLPMQL MRLMPRELTE QYGDLPPRVF ECRLAMVQPS1020
 1021 SVVSGNNRWS TAANDMLKTV AQCGLIDIEV YSLFNNVAAV LIHMRDGIIN DKLVELMLCR1080
 1081 RSDEDYMSRK DHDFRLRRQE SARNLSTAQR QQINEEYLRS CQLPQDHDLP PPPLEKCKTV1140
 1141 VMLKGPNSPL ECTMRSITRV GLSKRVNIDH LSVNALLLDA DPQDHHDHLI VAHEIAESRN1200
 1201 GQTLTARGTT LMPNVQGFGA LMVMLFSPTM QLKCNKEGTS YVSVLGGLGC DPDTNEPYFA1260
 1261 EHDVLINLDV NILEDDVILI NQIRYYIDSV FFNFKEENNP AVSVNERVSI YTQLRSLINR1320
 1321 LLCKDRRYIE RNMSNADFEW ETNPELPLPN EPFGKRAIFP MHSLTELQEE DTGRLVQLRE1380
 1381 NCSMLHKWRN FEGTLPHMTC KLCNQLLESV PQLRLHLLTI LHRDREKQID YCNQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..524] PSI-BLAST 62.39794 No description for 2hyiC was found.
    2 View Details [525..568] PSI-BLAST 7.0 Nucleotide excision repair enzyme UvrB
    3 View Details [569..699] FFAS03 1.13 No description for 2v8oA was found.
    4 View Details [700..881] MSA 1.54999 View MSA. No confident structure predictions are available.
    5 View Details [882..1146] PSI-BLAST 28.39794 No description for 2hqeA was found.
    6 View Details [1147..1353] deduced N/A No confident structure predictions are available.
    7 View Details [1354..1434] FFAS03 1.29 Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 4.704140727858 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.59795224939987 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.53105050016344 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.51138588650702 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.50855799768914 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • ATPase activity
    		•  1.98450701262305 bayes_pls_golite062009
  • transporter activity
    		•  1.96221407589423 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.80814406142572 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.77868357168224 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.68112322593144 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • hydrolase activity
    		•  1.22195710211319 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.862685397469217 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.77342981918307 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • motor activity
    		•  0.70874549510465 bayes_pls_golite062009
  • structural molecule activity
    		•  0.70126232242991 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • snRNA binding
    		•  0.418985924846052 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.397504938442906 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.312659433116074 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • translation release factor activity
    		•  0.178286731022211 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • translation termination factor activity
    		•  0.151456842619444 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • signal sequence binding
    		•  6.53725193420218E-4 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  3.34067645460735 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.21000367413295 bayes_pls_golite062009
  • binding
    		•  3.03932294945523 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.39870293911569 bayes_pls_golite062009
  • DNA binding
    		•  2.38812251097879 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.18526516649831 bayes_pls_golite062009
  • histone binding
    		•  2.01213085278409 bayes_pls_golite062009
  • protein binding
    		•  1.76914488602752 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.69262589010127 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.69262589010127 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.69262589010127 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.65392797012899 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  1.61102752615076 bayes_pls_golite062009
  • transcription factor binding
    		•  1.49481919243505 bayes_pls_golite062009
  • transcription factor activity
    		•  1.41108699101741 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.36802409360413 bayes_pls_golite062009
  • DNA (cytosine-5-)-methyltransferase activity
    		•  1.34644198396495 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.3138976673316 bayes_pls_golite062009
  • methylated histone residue binding
    		•  0.89251037476759 bayes_pls_golite062009
  • chromatin binding
    		•  0.8915883636553 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  0.56323697625529 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.53946303154276 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  0.52209845652926 bayes_pls_golite062009
  • transcription activator activity
    		•  0.262486595331603 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  0.223495463070134 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.141502107934206 bayes_pls_golite062009
    6 No functions predicted.
    7
    Term Confidence Notes
  • transcription regulator activity
    		•  4.47951889934838 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35187767955595 bayes_pls_golite062009
  • DNA binding
    		•  4.31051339571017 bayes_pls_golite062009
  • transcription factor activity
    		•  3.28758716579796 bayes_pls_golite062009
  • RNA binding
    		•  3.11293528368816 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.07956158665183 bayes_pls_golite062009
  • binding
    		•  2.99742524370422 bayes_pls_golite062009
  • snRNA binding
    		•  2.38635340504238 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.10135521534215 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.05542379535543 bayes_pls_golite062009
  • transcription activator activity
    		•  1.97757778483124 bayes_pls_golite062009
  • mRNA binding
    		•  1.28525296322454 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.26862497534835 bayes_pls_golite062009
  • chromatin binding
    		•  1.26688155139311 bayes_pls_golite062009
  • transcription factor binding
    		•  1.23738346570539 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.16887811832337 bayes_pls_golite062009
  • protein binding
    		•  0.952480850696098 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.776754909146767 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.627794176881836 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
  • histone binding
    		•  0.088089875173164 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0855506955761403 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle