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Protein Overview: hpo-PA, FBpp0304253

General Information:
Name(s) found: FBpp0304253 [FlyBase]
hpo-PA / FBpp0085688 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=2R:complement(15382187..15382908,15382966..15384253); ID=FBpp0304253; name=hpo-PB; parent=FBgn0261456,FBtr0331920; dbxref=FlyBase:FBpp0304253,FlyBase_Annotation_IDs:CG11228-PB,REFSEQ:NP_001261092,GB_protein:AGB93624; MD5=4450e9daeb2a8b636773c7b11142555f; length=669; release=r5.56; species=Dmel; [FlyBase]
  • The gene hippo is referred to in FlyBase by the symbol Dmel\hpo (CG11228, FBgn0261456). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15381801..15384372. It has the cytological map location 56D13. There is experimental evidence that it has the molecular function</span>: protein binding; protein serine/threonine kinase activity; kinase activity. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: regulation of biological process; regulation of apoptosis; anatomical structure development; positive regulation of programmed cell death; regulation of developmental process; sensory organ development; organ morphogenesis; organ development; negative regulation of cell death; cell proliferation; biopolymer modification; programmed cell death; response to ionizing radiation. 49 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: external compound sense organ; peripheral nervous system; adult segment; nervous system; thoracic segment; imaginal precursor; organ system; compound cell cluster organ; larval imaginal precursor; adult mesothoracic segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 669 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: cell proliferation [IMP]
    negative regulation of growth [TAS]
    negative regulation of cell proliferation [IMP]
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [IGI]
    negative regulation of organ growth [TAS]
    protein amino acid phosphorylation [IDA][NAS]
    morphogenesis of an epithelial sheet [IMP]
    regulation of cell proliferation [IMP][TAS]
    negative regulation of neuron apoptosis [IMP]
    negative regulation of transcription from RNA polymerase II promoter [NAS]
    eye development [IMP]
    induction of apoptosis [IMP]
    R8 cell fate specification [IMP]
    negative regulation of apoptosis [IMP]
    apoptosis [IMP]
    positive regulation of apoptosis [TAS]
    response to ionizing radiation [IMP]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [ISS][NAS]
    protein binding [IPI][NAS]
    protein serine/threonine kinase activity [IDA][NAS]
    kinase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEPEVTSVV DMKSPNISSS CSFFKLKKLS EESLLQPPEK VFDIMYKLGE GSYGSVYKAV  60
   61 HKESSSIVAI KLVPVESDLH EIIKEISIMQ QCDSPYVVRY YGSYFKQYDL WICMEYCGAG 120
  121 SVSDIMRLRK KTLTEDEIAT ILSDTLQGLV YLHLRRKIHR DIKAANILLN TEGYAKLADF 180
  181 GVAGQLTDTM AKRNTVIGTP FWMAPEVIEE IGYDCVADIW SLGITALEMA EGKPPYGEIH 240
  241 PMRAIFMIPQ KPPPSFREPD RWSTEFIDFV SKCLVKEPDD RATATELLEH EFIRNAKHRS 300
  301 ILKPMLEETC AIREQQRANR SFGGVLAASQ AKSLATQENG MQQHITDNAF MEDPGTLVPE 360
  361 KFGEYQQSSA SDATMIAHAE QGVDEGTLGP GGLRNLSKAA APAAASSAAS PLDMPAVDSG 420
  421 TMVELESNLG TMVINSDSDD STTAKNNDDQ KPRNRYRPQF LEHFDRKNAG DGRGDEKPIA 480
  481 TEYSPAAAEQ QQQQQQQQQQ QQQDEQHLAS GANDLNNWEH NMEMQFQQIS AINQYGLQQH 540
  541 QQQQQVLMAY PLMNEQLIAL NNQPNLLLSN AAPMGQQGIP AAAPAQPPPA YQNQHMHTQS 600
  601 HAYVEGEFEF LKFLTFDDLN QRLCNIDHEM ELEIEQLNKK YNAKRQPIVD AMNAKRKRQQ 660
  661 NINNNLIKI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..339] PSI-BLAST 68.69897 No description for 2j51A was found.
    2 View Details [340..564] deduced N/A No confident structure predictions are available.
    3 View Details [565..669] PSI-BLAST 5.0 FAT domain of focal adhesion kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.03984813433232 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.410563074162143 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.370400538296802 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.359826512663547 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.359163657047398 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle