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View Structure Prediction Details

Protein: hpo-PA, FBpp0304253
Organism: Drosophila melanogaster
Length: 669 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hpo-PA, FBpp0304253.

Description E-value Query
Range
Subject
Range
gi|73964109 - gi|73964109|ref|XP_868649.1| PREDICTED: similar to MAP/microtubule affinity-regulating kinase 3 (Cdc...
377.0 [0..16] [665..30]

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Predicted Domain #1
Region A:
Residues: [1-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEPEVTSVV DMKSPNISSS CSFFKLKKLS EESLLQPPEK VFDIMYKLGE GSYGSVYKAV  60
   61 HKESSSIVAI KLVPVESDLH EIIKEISIMQ QCDSPYVVRY YGSYFKQYDL WICMEYCGAG 120
  121 SVSDIMRLRK KTLTEDEIAT ILSDTLQGLV YLHLRRKIHR DIKAANILLN TEGYAKLADF 180
  181 GVAGQLTDTM AKRNTVIGTP FWMAPEVIEE IGYDCVADIW SLGITALEMA EGKPPYGEIH 240
  241 PMRAIFMIPQ KPPPSFREPD RWSTEFIDFV SKCLVKEPDD RATATELLEH EFIRNAKHRS 300
  301 ILKPMLEETC AIREQQRANR SFGGVLAASQ AKSLATQEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.69897
Match: 2j51A
Description: No description for 2j51A was found.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.03984813433232 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.410563074162143 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
pyrophosphatase activity 0.370400538296802 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.359826512663547 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.359163657047398 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
MAP kinase activity 0.08504542461349 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [340-564]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMQQHITDNA FMEDPGTLVP EKFGEYQQSS ASDATMIAHA EQGVDEGTLG PGGLRNLSKA  60
   61 AAPAAASSAA SPLDMPAVDS GTMVELESNL GTMVINSDSD DSTTAKNNDD QKPRNRYRPQ 120
  121 FLEHFDRKNA GDGRGDEKPI ATEYSPAAAE QQQQQQQQQQ QQQQDEQHLA SGANDLNNWE 180
  181 HNMEMQFQQI SAINQYGLQQ HQQQQQVLMA YPLMNEQLIA LNNQP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [565-669]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLLLSNAAPM GQQGIPAAAP AQPPPAYQNQ HMHTQSHAYV EGEFEFLKFL TFDDLNQRLC  60
   61 NIDHEMELEI EQLNKKYNAK RQPIVDAMNA KRKRQQNINN NLIKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1k04A
Description: FAT domain of focal adhesion kinase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle