YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: sax-PB

General Information:
Name(s) found: sax-PB / FBpp0087909 [FlyBase]
Description(s) found:
Found 21 descriptions.
SHOW ALL
  • The gene saxophone is referred to in FlyBase by the symbol Dmel\sax (CG1891, FBgn0003317). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3693983..3697575. It has the cytological map location 43E18. There is experimental evidence that it has the molecular function</span>: transforming growth factor beta receptor activity, type I. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; anatomical structure development; regulation of biological process; multicellular organism reproduction; regulation of developmental process; gamete generation; ovarian follicle cell development; organ development; regionalization; positive regulation of cellular component biogenesis; anterior/posterior axis specification; actin filament-based process. 40 alleles are reported. The phenotypes of these alleles are annotated with 34 unique terms, many of which group under: adult segment; adult mesothoracic segment; organ system; peripheral nervous system; germarium; egg; external compound sense organ; embryonic/larval tracheal system; extended germ band embryo; nervous system; imaginal precursor; cell component. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 535 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    plasma membrane [ISS]
    Biological Process: transforming growth factor beta receptor signaling pathway [ISS][NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    ovarian nurse cell to oocyte transport [TAS]
    actin filament organization [IMP]
    germ-line stem cell division [IMP]
    decapentaplegic receptor signaling pathway [IGI][IMP]
    chorion-containing eggshell formation [IGI]
    protein amino acid phosphorylation [IEA][NAS]
    anterior/posterior pattern formation, imaginal disc [IMP]
    positive regulation of synaptic growth at neuromuscular junction [IMP]
    maternal determination of anterior/posterior axis, embryo [IGI][IMP]
    dorsal/ventral pattern formation [IGI][IMP]
    negative regulation of BMP signaling pathway [IMP]
    oogenesis [IMP]
    compound eye morphogenesis [NAS]
    BMP signaling pathway [TAS]
    ovarian follicle cell development [IMP][TAS]
    germ-line stem cell maintenance [IMP]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [NAS]
    transforming growth factor beta receptor activity, type I [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELSSASSAH LNGKELPAVP QNSVQTHPRY KCYSCEPPCR DPYEFTHTCQ NAIQCWKSRT  60
   61 RDADGQVQES RGCSTSPDQL PMICSQNSLK INGPSKRNTG KFVNVVCCAG DYCNEGDFPE 120
  121 LLPFDSNDVT VITADTSSIS KMLVAVLGPF LVIALLGAVT IFFIRRSHRK RLAASRTKQD 180
  181 PEAYLVNDEL LRATSAGDST LREYLQHSVT SGSGSGLPLL VQRTLAKQVT LIECIGRGKY 240
  241 GEVWRGHWHG ESIAVKIFFS RDEESWKRET EIYSTILLRH ENILGFIGSD MTSRNSCTQL 300
  301 WLMTHYYPLG SLFDHLNRNA LSHNDMVWIC LSIANGLVHL HTEIFGKQGK PAMAHRDLKS 360
  361 KNILVTSNGS CVIADFGLAV THSHVTGQLD LGNNPKVGTK RYMAPEVLDE SIDLECFEAL 420
  421 RRTDIYAFGL VLWEVCRRTI SCGIAEEYKV PFYDVVPMDP SFEDMRKVVC IDNYRPSIPN 480
  481 RWSSDSLMTG MSKLMKECWH QNPDVRLPAL RIKKTIHKLA SADEKIRLDF DEVCV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..169] PSI-BLAST 7.522879 Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor
    2 View Details [170..535] PSI-BLAST 75.69897 Type I TGF-beta receptor R4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transmembrane receptor protein serine/threonine kinase binding
    		•  3.29432547587631 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  3.29432547587631 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  2.91714500246524 bayes_pls_golite062009
  • receptor activity
    		•  2.74055213309696 bayes_pls_golite062009
  • U-plasminogen activator receptor activity
    		•  2.67622889349209 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.63843756028069 bayes_pls_golite062009
  • signal transducer activity
    		•  2.51859905018984 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.51859905018984 bayes_pls_golite062009
  • protein binding
    		•  2.27773193148456 bayes_pls_golite062009
  • growth factor binding
    		•  2.11370016324137 bayes_pls_golite062009
  • SMAD binding
    		•  2.11166655078306 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.93573786819729 bayes_pls_golite062009
  • binding
    		•  1.78861011884769 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.72562399286061 bayes_pls_golite062009
  • cytokine binding
    		•  1.30600639196836 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  1.10571389507211 bayes_pls_golite062009
  • receptor binding
    		•  0.899783960746717 bayes_pls_golite062009
  • enzyme binding
    		•  0.61951403712284 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.227519165953748 bayes_pls_golite062009
  • pattern binding
    		•  0.21003196804615 bayes_pls_golite062009
    2
    Term Confidence Notes
  • activin receptor activity
    		•  9.43409082112081 bayes_pls_golite062009
  • activin binding
    		•  7.11944534332244 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  6.41728494915949 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  6.1393596497059 bayes_pls_golite062009
  • protein kinase activity
    		•  5.63683237027974 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.46123870227889 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • follistatin binding
    		•  3.25716461198789 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.97315540587667 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  2.57601476622612 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  2.54478169273822 bayes_pls_golite062009
  • actin binding
    		•  2.42703012169921 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.38494443043195 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • binding
    		•  2.10874590528357 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • insulin receptor activity
    		•  2.08642574110801 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  2.08248852174113 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • activin receptor activity, type II
    		•  1.93639573827674 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.90879495821405 bayes_pls_golite062009
  • MAP kinase kinase kinase kinase activity
    		•  1.70795227184717 bayes_pls_golite062009
  • actin filament binding
    		•  1.68048469859634 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  1.54033709235083 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  1.46877913443522 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.39074764291742 bayes_pls_golite062009
  • amine binding
    		•  1.3051205627964 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • PTB domain binding
    		•  1.14009984975509 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • cytokine receptor binding
    		•  1.08904623349766 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • insulin binding
    		•  1.03564126441771 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • stem cell factor receptor activity
    		•  0.877914726874139 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.620804584416924 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.620804584416924 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.58590430118616 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.527255160265651 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • DNA binding
    		•  0.392505747359251 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type II
    		•  0.365530951355731 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.34434685718027 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.33253160432275 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.312169974523858 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.294256794094724 bayes_pls_golite062009
  • inhibin binding
    		•  0.29024207998068 bayes_pls_golite062009
  • inhibin beta-B binding
    		•  0.29024207998068 bayes_pls_golite062009
  • inhibin beta-A binding
    		•  0.29024207998068 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.289778841954859 bayes_pls_golite062009
  • collagen binding
    		•  0.249197530511006 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.229808864843639 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.213371031328104 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • epidermal growth factor receptor activity
    		•  0.160217511793891 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • transcription factor activity
    		•  0.140216630442397 bayes_pls_golite062009
  • transcription activator activity
    		•  0.088753929713159 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.0123645889643007 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.96656737540424E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle