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Protein Overview: TNFA_RAT

General Information:
Name(s) found: TNFA_RAT [Swiss-Prot]
Description(s) found:
Found 36 descriptions.
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  • Tumor necrosis factor OS=Rattus norvegicus GN=Tnf PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 235 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [UNKNOWN][IEA]
    extracellular space [UNKNOWN][IDA][TAS]
    membrane raft [UNKNOWN][IEA]
    integral to membrane [IDA]
    extracellular region [IEA]
    plasma membrane [UNKNOWN][IEA]
    cell surface [UNKNOWN]
    Biological Process: JNK cascade [UNKNOWN]
    positive regulation of mitosis [IMP]
    glucose metabolic process [UNKNOWN][IEA]
    induction of apoptosis via death domain receptors [UNKNOWN][IEA]
    positive regulation of transcription factor activity [UNKNOWN]
    induction of apoptosis by extracellular signals [UNKNOWN]
    positive regulation of NF-kappaB transcription factor activity [UNKNOWN][IEA]
    negative regulation of L-glutamate transport [IDA]
    activation of MAPK activity [UNKNOWN][IEA]
    regulation of insulin secretion [UNKNOWN][IEA]
    inflammatory response [UNKNOWN][TAS]
    positive regulation of chronic inflammatory response to antigenic stimulus [UNKNOWN]
    positive regulation of gene-specific transcription [UNKNOWN][IEA]
    anti-apoptosis [UNKNOWN][IEA]
    positive regulation of membrane protein ectodomain proteolysis [UNKNOWN][IEA]
    induction of apoptosis [UNKNOWN][IDA]
    chronic inflammatory response to antigenic stimulus [UNKNOWN][IEA]
    protein import into nucleus, translocation [UNKNOWN][IEA]
    apoptosis [IDA]
    humoral immune response [UNKNOWN][IEA]
    positive regulation of interferon-gamma production [UNKNOWN]
    positive regulation of cytokine secretion [UNKNOWN][IEA]
    activation of caspase activity [UNKNOWN][IEA]
    calcium-mediated signaling [IDA]
    positive regulation of chemokine production [UNKNOWN][IEA]
    receptor biosynthetic process [UNKNOWN][IEA]
    defense response to Gram-positive bacterium [UNKNOWN]
    negative regulation of lipid catabolic process [UNKNOWN][IEA]
    negative regulation of branching involved in lung morphogenesis [UNKNOWN]
    positive regulation of inflammatory response [IMP]
    positive regulation of synaptic transmission [IMP]
    positive regulation of calcidiol 1-monooxygenase activity [UNKNOWN][IEA]
    positive regulation of NF-kappaB import into nucleus [UNKNOWN][IEA]
    defense response to bacterium [UNKNOWN][IEA]
    induction of necroptosis by extracellular signals [UNKNOWN][IEA]
    organ morphogenesis [UNKNOWN][IEA]
    positive regulation of vitamin D biosynthetic process [UNKNOWN][IEA]
    negative regulation of interleukin-6 production [UNKNOWN][IEA]
    tumor necrosis factor-mediated signaling pathway [UNKNOWN][IEA]
    transformed cell apoptosis [UNKNOWN][IEA]
    negative regulation of growth of symbiont in host [UNKNOWN]
    negative regulation of transcription [UNKNOWN][IEA]
    positive regulation of humoral immune response mediated by circulating immunoglobulin [UNKNOWN]
    sequestering of triglyceride [UNKNOWN][IEA]
    positive regulation of interleukin-6 production [UNKNOWN][IEA]
    positive regulation of nitric oxide biosynthetic process [UNKNOWN][IEA]
    multicellular organismal development [UNKNOWN][IEA]
    negative regulation of cell proliferation [IDA]
    positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN][IGI]
    regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN]
    positive regulation of transcription [UNKNOWN][IEA]
    response to virus [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    epithelial cell proliferation involved in salivary gland morphogenesis [UNKNOWN][IEA]
    positive regulation of neuron apoptosis [IMP]
    negative regulation of cytokine secretion during immune response [UNKNOWN][IEA]
    response to mechanical stimulus [IEP]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    positive regulation of smooth muscle cell proliferation [UNKNOWN][IEA]
    positive regulation of protein transport [IDA]
    necrotic cell death [UNKNOWN]
    regulation of immunoglobulin secretion [UNKNOWN][IEA]
    regulation of osteoclast differentiation [UNKNOWN][IEA]
    response to glucocorticoid stimulus [UNKNOWN][IEA]
    positive regulation of interleukin-18 production [IMP]
    negative regulation of viral genome replication [UNKNOWN][IEA]
    regulation of branching involved in salivary gland morphogenesis [UNKNOWN][IEA]
    negative regulation of gene-specific transcription [UNKNOWN]
    signal transduction [IDA]
    negative regulation of glucose import [UNKNOWN][IDA]
    positive regulation of translational initiation by iron [UNKNOWN][IEA]
    defense response [UNKNOWN]
    regulation of cell proliferation [UNKNOWN]
    osteoclast differentiation [UNKNOWN]
    cell activation [IDA]
    regulation of protein amino acid phosphorylation [UNKNOWN]
    cellular extravasation [UNKNOWN]
    response to drug [IEP]
    negative regulation of apoptosis [UNKNOWN]
    positive regulation of JNK cascade [UNKNOWN][IEA]
    positive regulation of protein amino acid phosphorylation [UNKNOWN][IEA]
    positive regulation of apoptosis [IMP]
    extracellular matrix organization [UNKNOWN][IEA]
    positive regulation of heterotypic cell-cell adhesion [UNKNOWN][IEA]
    leukocyte migration [UNKNOWN]
    leukocyte tethering or rolling [UNKNOWN][IEA]
    positive regulation of cytokine production [UNKNOWN]
    positive regulation of chemokine biosynthetic process [UNKNOWN][IEA]
    Molecular Function: identical protein binding [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    tumor necrosis factor receptor binding [UNKNOWN][IDA][TAS]
    promoter binding [UNKNOWN]
    transcription activator activity [UNKNOWN]
    cytokine activity [UNKNOWN][TAS]
    transcription repressor activity [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTESMIRDV ELAEEALPKK MGGLQNSRRC LCLSLFSFLL VAGATTLFCL LNFGVIGPNK  60
   61 EEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ AEEQLEWLSQ RANALLANGM 120
  121 DLKDNQLVVP ADGLYLIYSQ VLFKGQGCPD YVLLTHTVSR FAISYQEKVS LLSAIKSPCP 180
  181 KDTPEGAELK PWYEPMYLGG VFQLEKGDLL SAEVNLPKYL DITESGQVYF GVIAL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle