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Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor. Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. The process whereby a protein/peptide signal causes activation of a receptor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: tumor necrosis factor-mediated signaling pathway
Acc: GO:0033209
Aspect: Biological Process
Desc: A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
Synonyms:
  • tumor necrosis factor alpha-mediated signaling pathway
  • adipocytokine signaling pathway
  • TNF-alpha-mediated signaling pathway
  • tumor necrosis factor-mediated signalling pathway
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0033209 - tumor necrosis factor-mediated signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle