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The process of apoptosis in transformed cells, cells that have undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm. A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. Cell death resulting from activation of endogenous cellular processes.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: transformed cell apoptosis
Acc: GO:0006927
Aspect: Biological Process
Desc: The process of apoptosis in transformed cells, cells that have undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm.
Synonyms:
  • killing transformed cells
  • apoptosis of transformed cells
  • programmed cell death of transformed cells by apoptosis
  • programmed cell death, transformed cells
  • transformed cell programmed cell death by apoptosis
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006927 - transformed cell apoptosis (interactive image map)
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Created and Maintained by: Michael Riffle