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Protein Overview: MECP2_RAT

General Information:
Name(s) found: MECP2_RAT [Swiss-Prot]
Description(s) found:
Found 16 descriptions.
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  • Methyl-CpG-binding protein 2 OS=Rattus norvegicus GN=Mecp2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: heterochromatin [UNKNOWN][IEA]
    nucleus [UNKNOWN][IDA][IEA]
    nuclear chromatin [IDA]
    cytoplasm [UNKNOWN][IEA]
    cytosol [UNKNOWN][IDA]
    protein complex [IDA]
    Biological Process: embryonic development [UNKNOWN][IEA]
    post-embryonic development [UNKNOWN][IEA]
    protein localization [UNKNOWN][IEA]
    adult locomotory behavior [UNKNOWN][IEA]
    visual learning [UNKNOWN][IEA]
    regulation of respiratory gaseous exchange by neurological system process [UNKNOWN][IEA]
    mitochondrial electron transport, ubiquinol to cytochrome c [UNKNOWN][IEA]
    learning [UNKNOWN]
    regulation of transcription [UNKNOWN][IEA]
    memory [UNKNOWN]
    response to hypoxia [UNKNOWN][IEA]
    catecholamine secretion [UNKNOWN][IEA]
    negative regulation of transcription, DNA-dependent [UNKNOWN][IDA]
    positive regulation of transcription, DNA-dependent [UNKNOWN][IEA]
    regulation of synaptic plasticity [UNKNOWN]
    histone methylation [UNKNOWN]
    cardiolipin metabolic process [UNKNOWN][IEA]
    histone acetylation [UNKNOWN]
    long-term synaptic potentiation [UNKNOWN][IEA]
    positive regulation of synaptogenesis [UNKNOWN][IEA]
    regulation of excitatory postsynaptic membrane potential [UNKNOWN][IEA]
    cerebellum development [UNKNOWN][IEA]
    neuron differentiation [UNKNOWN][IEA]
    synaptic transmission [UNKNOWN][IEA]
    brain development [UNKNOWN]
    respiratory gaseous exchange [UNKNOWN][IEA]
    pathogenesis [UNKNOWN][IEA]
    cellular biogenic amine metabolic process [UNKNOWN][IEA]
    long-term memory [UNKNOWN][IEA]
    ventricular system development [UNKNOWN][IEA]
    neuromuscular process controlling posture [UNKNOWN]
    synapse assembly [UNKNOWN]
    phosphatidylcholine metabolic process [UNKNOWN][IEA]
    proprioception [UNKNOWN][IEA]
    negative regulation of transcription [UNKNOWN]
    sensory perception of pain [UNKNOWN][IEA]
    negative regulation of histone methylation [UNKNOWN][IEA]
    negative regulation of histone acetylation [UNKNOWN][IEA]
    inositol metabolic process [UNKNOWN][IEA]
    positive regulation of cell proliferation [UNKNOWN][IEA]
    glutamine metabolic process [UNKNOWN][IEA]
    neuron maturation [UNKNOWN][IEA]
    chromatin silencing [UNKNOWN][IEA]
    negative regulation of neuron apoptosis [UNKNOWN][IEA]
    negative regulation of transcription from RNA polymerase II promoter [IDA]
    startle response [UNKNOWN][IEA]
    dendrite development [UNKNOWN][IEA]
    social behavior [UNKNOWN][IEA]
    neuron projection development [UNKNOWN]
    neuromuscular process [UNKNOWN]
    glucocorticoid metabolic process [UNKNOWN][IEA]
    response to stress [UNKNOWN]
    regulation of gene expression, epigenetic [UNKNOWN]
    behavioral fear response [UNKNOWN][IEA]
    regulation of gene expression by genetic imprinting [UNKNOWN][IEA]
    neurological system process involved in regulation of systemic arterial blood pressure [UNKNOWN][IEA]
    Molecular Function: chromatin DNA binding [IDA]
    double-stranded methylated DNA binding [UNKNOWN][IDA]
    protein domain specific binding [UNKNOWN]
    siRNA binding [UNKNOWN][IEA]
    unmethylated CpG binding [IDA]
    transcription factor binding [UNKNOWN][IEA]
    four-way junction DNA binding [IDA]
    methyl-CpG binding [UNKNOWN][IDA]
    DNA binding [UNKNOWN][IEA]
    transcription factor activity [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    protein N-terminus binding [UNKNOWN]
    mRNA binding [UNKNOWN][IEA]
    transcription repressor activity [UNKNOWN][IDA]
    enzyme binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAGMLGLRK EKSEDQDLQG LKEKPLKFKK VKKDKKEDKE GKHEPLQPSA HHSAEPAEAG  60
   61 KAETSESSGS APAVPEASAS PKQRRSIIRD RGPMYDDPTL PEGWTRKLKQ RKSGRSAGKY 120
  121 DVYLINPQGK AFRSKVELIA YFEKVGDTSL DPNDFDFTVT GRGSPSRREQ KPPKKPKSPK 180
  181 APGTGRGRGR PKGSGTGRPK AAASEGVQVK RVLEKSPGKL LVKMPFQASP GGKGEGGGAT 240
  241 TSAQVMVIKR PGRKRKAEAD PQAIPKKRGR KPGSVVAAAA AEAKKKAVKE SSIRSVQETV 300
  301 LPIKKRKTRE TVSIEVKEVV KPLLVSTLGE KSGKGLKTCK SPGRKSKESS PKGRSSSASS 360
  361 PPKKEHHHHH HHAESPKAPM PLLPPPPPPE PQSSEDPISP PEPQDLSSSI CKEEKMPRAG 420
  421 SLESDGCPKE PAKTQPMVAA AATTTTTTTT TVAEKYKHRG EGERKDIVSS SMPRPNREEP 480
  481 VDSRTPVTER VS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle