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Protein Overview: TNFA_MOUSE

General Information:
Name(s) found: TNFA_MOUSE [Swiss-Prot]
Description(s) found:
Found 45 descriptions.
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  • Tumor necrosis factor OS=Mus musculus GN=Tnf PE=1 SV=2 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 235 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [TAS]
    extracellular space [UNKNOWN][IDA]
    secretory granule [TAS]
    membrane [IEA]
    membrane raft [IDA]
    integral to membrane [UNKNOWN]
    external side of plasma membrane [IDA]
    recycling endosome [IDA]
    extracellular region [IEA]
    phagocytic cup [IDA]
    plasma membrane [IDA]
    Biological Process: JNK cascade [IGI]
    positive regulation of mitosis [UNKNOWN]
    glucose metabolic process [IDA]
    induction of apoptosis via death domain receptors [IGI]
    induction of apoptosis by extracellular signals [IDA]
    positive regulation of NF-kappaB transcription factor activity [UNKNOWN]
    negative regulation of L-glutamate transport [UNKNOWN]
    inflammatory response [TAS]
    immune response [IEA]
    positive regulation of chronic inflammatory response to antigenic stimulus [IGI]
    induction of apoptosis [UNKNOWN][IDA]
    humoral immune response [IMP]
    apoptosis [UNKNOWN]
    positive regulation of interferon-gamma production [IGI]
    calcium-mediated signaling [UNKNOWN]
    defense response to Gram-positive bacterium [IGI]
    positive regulation of synaptic transmission [UNKNOWN]
    defense response to bacterium [IDA]
    organ morphogenesis [IMP]
    tumor necrosis factor-mediated signaling pathway [IDA]
    transformed cell apoptosis [TAS]
    negative regulation of growth of symbiont in host [IGI]
    positive regulation of humoral immune response mediated by circulating immunoglobulin [IGI]
    positive regulation of interleukin-6 production [IDA]
    cell proliferation [TAS]
    multicellular organismal development [IMP]
    negative regulation of cell proliferation [UNKNOWN]
    positive regulation of cell proliferation [TAS]
    positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN][IDA][IGI]
    positive regulation of transcription [IDA]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    epithelial cell proliferation involved in salivary gland morphogenesis [IDA]
    positive regulation of neuron apoptosis [UNKNOWN]
    negative regulation of transcription from RNA polymerase II promoter [IDA]
    positive regulation of protein transport [UNKNOWN]
    regulation of immunoglobulin secretion [IDA]
    regulation of osteoclast differentiation [IDA]
    regulation of branching involved in salivary gland morphogenesis [IDA][IMP]
    signal transduction [UNKNOWN]
    negative regulation of glucose import [UNKNOWN][IDA]
    positive regulation of translational initiation by iron [IDA]
    defense response [IMP]
    regulation of cell proliferation [IDA]
    osteoclast differentiation [IGI]
    cell activation [UNKNOWN]
    cellular extravasation [IDA]
    regulation of protein amino acid phosphorylation [IDA]
    positive regulation of JNK cascade [IDA][IGI]
    extracellular matrix organization [IDA]
    leukocyte migration [IDA]
    positive regulation of hair follicle development [IMP]
    Molecular Function: protein binding [IPI]
    tumor necrosis factor receptor binding [UNKNOWN][IDA][IPI][TAS]
    cytokine activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL LNFGVIGPQR  60
   61 DEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ VEEQLEWLSQ RANALLANGM 120
  121 DLKDNQLVVP ADGLYLVYSQ VLFKGQGCPD YVLLTHTVSR FAISYQEKVN LLSAVKSPCP 180
  181 KDTPEGAELK PWYEPIYLGG VFQLEKGDQL SAEVNLPKYL DFAESGQVYF GVIAL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..235] PSI-BLAST 58.39794 Tumor necrosis factor (TNF)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • tumor necrosis factor receptor binding
    		•  4.41551127334596 bayes_pls_golite062009
  • receptor binding
    		•  3.37824597039547 bayes_pls_golite062009
  • tumor necrosis factor receptor superfamily binding
    		•  3.27382150819697 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  2.99764886866547 bayes_pls_golite062009
  • protein binding
    		•  2.25413201891408 bayes_pls_golite062009
  • cytokine activity
    		•  2.15273244126886 bayes_pls_golite062009
  • binding
    		•  1.76110862494815 bayes_pls_golite062009
  • CD40 receptor binding
    		•  1.32291890442774 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  1.28185157337226 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  1.2326564264318 bayes_pls_golite062009
  • cell surface binding
    		•  1.12145675554147 bayes_pls_golite062009
  • structural molecule activity
    		•  0.402748748247022 bayes_pls_golite062009
  • eukaryotic cell surface binding
    		•  0.3981620493951 bayes_pls_golite062009
  • hormone activity
    		•  0.0434508002092211 bayes_pls_golite062009
  • caspase inhibitor activity
    		•  0.0237319623798404 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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