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View Structure Prediction Details

Protein: TNFA_MOUSE
Organism: Mus musculus
Length: 235 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TNFA_MOUSE.

Description E-value Query
Range		 Subject
Range
TNFA_CANLF - Tumor necrosis factor OS=Canis lupus familiaris GN=TNF PE=2 SV=1
 339.0 [0..1] [235..1]
TNF - tumor necrosis factor
gi|123996347, gi... - gi|61358334|gb|AAX41550.1| tumor necrosis factor [synthetic construct], gi|208968003|dbj|BAG73840.1|...
gi|114606345, gi... - gi|90960856|dbj|BAE92774.1| tumor necrosis factor alpha [Pan troglodytes], gi|90960853|dbj|BAE92772....
 339.0 [0..1] [235..1]
gi|60828080 - gi|60828080|gb|AAX36827.1| tumor necrosis factor [synthetic construct]
 339.0 [0..1] [235..1]
TNFA_MACMU - Tumor necrosis factor OS=Macaca mulatta GN=TNF PE=2 SV=1
 338.0 [0..1] [235..1]
gi|2570070, gi|3... - gi|395370|emb|CAA47146.1| tumor necrosis factor-alpha [Rattus norvegicus], gi|2570070|emb|CAA05290.1...
 338.0 [0..1] [235..1]
gi|3805811 - gi|3805811|emb|CAA75070.1| tumor necrosis facor [Homo sapiens]
TNFA_PANTR - Tumor necrosis factor OS=Pan troglodytes GN=TNF PE=3 SV=2
 337.0 [0..1] [235..1]
TNFA_CAVPO - Tumor necrosis factor OS=Cavia porcellus GN=TNF PE=2 SV=1
 337.0 [0..1] [235..1]
TNFA_PAPHU - Tumor necrosis factor OS=Papio hamadryas ursinus GN=TNF PE=2 SV=1
 336.0 [0..1] [235..1]

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Predicted Domain #1
Region A:
Residues: [1-235] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL LNFGVIGPQR  60
   61 DEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ VEEQLEWLSQ RANALLANGM 120
  121 DLKDNQLVVP ADGLYLVYSQ VLFKGQGCPD YVLLTHTVSR FAISYQEKVN LLSAVKSPCP 180
  181 KDTPEGAELK PWYEPIYLGG VFQLEKGDQL SAEVNLPKYL DFAESGQVYF GVIAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.39794
Match: 2tnfA
Description: Tumor necrosis factor (TNF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
tumor necrosis factor receptor binding 4.41551127334596 bayes_pls_golite062009
receptor binding 3.37824597039547 bayes_pls_golite062009
tumor necrosis factor receptor superfamily binding 3.27382150819697 bayes_pls_golite062009
extracellular matrix structural constituent 2.99764886866547 bayes_pls_golite062009
protein binding 2.25413201891408 bayes_pls_golite062009
cytokine activity 2.15273244126886 bayes_pls_golite062009
binding 1.76110862494815 bayes_pls_golite062009
CD40 receptor binding 1.32291890442774 bayes_pls_golite062009
peptidase inhibitor activity 1.28185157337226 bayes_pls_golite062009
endopeptidase inhibitor activity 1.2326564264318 bayes_pls_golite062009
cell surface binding 1.12145675554147 bayes_pls_golite062009
structural molecule activity 0.402748748247022 bayes_pls_golite062009
eukaryotic cell surface binding 0.3981620493951 bayes_pls_golite062009
hormone activity 0.0434508002092211 bayes_pls_golite062009
caspase inhibitor activity 0.0237319623798404 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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