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Protein Overview: MPS3

General Information:
Name(s) found: MPS3 / YJL019W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 682 amino acids

    Gene Ontology:
    Cellular Component: half bridge of spindle pole body [IDALink to PubMed article]
    integral to membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: mitotic sister chromatid cohesion [IMPLink to PubMed article]
    spindle pole body duplication in nuclear envelope [IMPLink to PubMed article]
    nuclear migration during conjugation with cellular fusion [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNSNEHRRE EAGAANEQMP YNKAVKSAYA DVLKDKMNRE QEISLRAIKK GIYTDGGETD  60
   61 NYDMDKENDS AYEMFKKNLD FPLDQHNDDD DDDPYIEDNG QETDGYSDED YTDEADKSFI 120
  121 EDSDSDSYDL ESNSDFEENL ESSGEAKKLK WRTYIFYGGL FFVFYFFGSF LMTTVKNNDL 180
  181 ESHSSGATSS PGKSFSNLQK QVNHLYSELS KRDEKHSSEL DKTVKIIVSQ FEKNIKRLLP 240
  241 SNLVNFENDI NSLTKQVETI STSMSELQRR NHKFTVENVT QWQDQLVKQL DTHLPQEIPV 300
  301 VINNSSSLLI IPELHNYLSA LISDVIESPG IGTAGSAESR WEYDLNRYVK EILSNELQYI 360
  361 DKDYFIQEMN RRLQSNKQEI WEEITNRLET QQQQQQQQVQ QDYSNVPQQY SSILMKRLIH 420
  421 QIYNSNQHQW EDDLDFATYV QGTKLLNHLT SPTWRQGSGV QPIELLTDSK QSSSTYWQCE 480
  481 NEPGCSWAIR FKTPLYLTKI SYMHGRFTNN LHIMNSAPRL ISLYVKLSQT KEIKALQTLA 540
  541 NQYGFGQHHK RDRNYIKIAK FEYRLTDSRI RQQMYLPPWF IQLKPLVRSI VFQVDENYGN 600
  601 KKFISLRKFI INGVTPQDLQ IIENNEFPVL LGDTPEYGVT QNTDEGKRKV LLSKPPYASS 660
  661 STSTKFHPAS NVPSFGQDEL DQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) CDC31 KAR1 MPS3 SFI1 SPC29 SPC42 SPC98

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ECO1 MPS3 2 Unpublished Fields Lab Data
    View Screen PHS1 MPS3 2 Unpublished Fields Lab Data
    View Screen YJL147C MPS3 2 Unpublished Fields Lab Data
    View Screen EST1 MPS3 2 Uetz P, et al. (2000)
    View Screen SST2 MPS3 2 Unpublished Fields Lab Data
    View Screen ELA1 MPS3 2 Unpublished Fields Lab Data
    View Screen YIF1 MPS3 2 Unpublished Fields Lab Data
    View Screen HTZ1 MPS3 2 Uetz P, et al. (2000)
    View Screen SPO21 MPS3 2 Unpublished Fields Lab Data
    View Screen PRM3 MPS3 2 Unpublished Fields Lab Data
    View Screen DAS1 MPS3 1 Unpublished Fields Lab Data
    View Screen TEM1 MPS3 1 Unpublished Fields Lab Data
    View Screen CTF13 MPS3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MPS3 Sundin BA, et al. (2004)
    View Data MPS3 Sundin BA, et al. (2004)
    View Data MPS3 and SPC29 Sundin BA, et al. (2004)
    View Data MPS3 and SPC29 Sundin BA, et al. (2004)
    View Data MPS3 Huh WK, et al. (2003)
    View Data MPS3 and SPC42 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..180] deduced N/A No confident structure predictions are available.
    2 View Details [181..332] deduced N/A No confident structure predictions are available.
    3 View Details [333..575] deduced N/A No confident structure predictions are available.
    4 View Details [576..682] MSA 1.004976 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.13881908809926 bayes_pls_golite062009
  • protein binding
    		•  1.02790379418228 bayes_pls_golite062009
  • receptor activity
    		•  0.850578317637287 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.718598814428587 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.081069822885576 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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