Protein Overview: GRP78_RAT

General Information:
Name(s) found:	GRP78_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|38303969\|gb\|AAH62017.1\| Heat shock protein 5 [Rattus norvegicus] [NCBI NR] pir\|\|HHRTGB dnaK-type molecular chaperone precursor - rat [NCBI NR] gi\|25742763\|ref\|NP_037215.1\| heat shock protein 5 [Rattus norvegicus] [NCBI NR] gi\|203151\|gb\|AAA40817.1\| preimmunoglobulin heavy chain binding protein [NCBI NR] gi\|149038950\|gb\|EDL93170.1\| heat shock 70kDa protein 5 (glucose-regulated protein), isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149038949\|gb\|EDL93169.1\| heat shock 70kDa protein 5 (glucose-regulated protein), isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|121574\|sp\|P06761.1\|GRP78_RAT RecName: Full=78 kDa glucose-regulated protein; AltName: Full=GRP 78; AltName: Full=Heat shock 70 kDa protein 5; AltName: Full=Immunoglobulin heavy chain-binding protein; Short=BiP; AltName: Full=Steroidogenesis-activator p [NCBI NR] 78 kDa glucose-regulated protein OS=Rattus norvegicus GN=Hspa5 PE=1 SV=1 [Swiss-Prot] (P06761) 78 kDa glucose-regulated protein precursor (GRP 78) (Immunoglobulin heavy chain binding protein) (BiP) (Steroidogenesis-activator polypeptide) [Swiss-Prot] 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN... [hmr_yeast5_DM3-1_pombe.fasta] Ensembl_locations(Chr-bp):3-13808425 78 kDa glucose-regulated protein precursor [hmr_yeast5_DM3-1_pombe.fasta] owl\|P06761\| 78 KD GLUCOSE REGULATED PROTEIN PRECURSOR (GRP 78) (IMMUNOGLOBULIN... [765database.fasta] heat shock 70kD protein 5 [HMR_022704-rand.fasta] heat shock 70kD protein 5 [Rattus norvegicus]gi\|38303969\|gb\|AAH62017.1\| Heat shock 70kD protein 5 [Rattus norvegicus]gi\|121574\|sp\|P06761\|GR78_RAT 78 kDa glucose-regulated protein precursor (GRP 78) (Immunoglobulin heavy chain binding protein) (BiP) (Ste [nrdb_11152004_Chlamydomonas] Tax_Id=10116 78 kDa glucose-regulated protein precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Ensembl_locations(Chr-bp):3-13808425 78 kDa glucose-regulated protein precursor [EBI-IPI_Drosophila_na_12-13-2007_con_reversed.fasta] 78 kDa glucose-regulated protein precursor (GRP 78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) (Steroidogenesis-activator polypeptide) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Heat shock protein 5 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] heat shock protein 5 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] heat shock 70kDa protein 5 (glucose-regulated protein), isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] preimmunoglobulin heavy chain binding protein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 78 KDA GLUCOSE-REGULATED PROTEIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Heat shock 70kDa protein 5 (glucose-regulated protein) [Rattus norvegicus] [nr-271106-contam.fasta] heat shock 70kD protein 5 [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Hspa5 78 kDa glucose-regulated protein [rat-ipi-250309-contam.fasta] heat shock protein 5 precursor [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] 78 kDa glucose-regulated protein OS=Rattus norvegicus GN=Hspa5 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	654 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IEA] endoplasmic reticulum lumen [IEA] perinuclear region of cytoplasm [UNKNOWN][IEA] melanosome [IEA] integral to endoplasmic reticulum membrane [UNKNOWN][IEA] endoplasmic reticulum [UNKNOWN][TAS] ER-Golgi intermediate compartment [UNKNOWN][IEA] caspase complex [UNKNOWN][IEA] cell surface [UNKNOWN][IEA]
Biological Process:	cerebellar Purkinje cell layer development [IEA] activation of signaling protein activity involved in unfolded protein response [IEA] anti-apoptosis [UNKNOWN] negative regulation of apoptosis [UNKNOWN] negative regulation of caspase activity [UNKNOWN][IEA] positive regulation of protein ubiquitination [IEA] cerebellum structural organization [IEA] ER overload response [UNKNOWN][IEA] negative regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA] cellular response to glucose starvation [UNKNOWN][IEA]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] protein binding [UNKNOWN][IPI] ribosome binding [UNKNOWN][IEA] caspase inhibitor activity [UNKNOWN][IEA] ATP-dependent protein binding [IEA] misfolded protein binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFTVVAAAL LLLCAVRAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR  60
   61 ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV 120
  121 EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 180
  181 RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG 240
  241 VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS 300
  301 SQHQARIEIE SFFEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV 360
  361 LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC 420
  421 PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG 480
  481 TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER 540
  541 MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSPED KETMEKAVEE 600
  601 KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSGGP PPTGEEDTSE KDEL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	BIM1	No Comments	Cheeseman IM, et al. (2002)
View Run	TOR1	No Comments	Reinke A, et al. (2004)
View Run	LST8	No Comments	Reinke A, et al. (2004)
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	CLB2	No Comments	McCusker D, et al (2007)
View Run	CLB2	No Comments	McCusker D, et al (2007)
View Run	CLB2	No Comments	McCusker D, et al (2007)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	CENPA	No Comments	Foltz DR, et al (2006)
View Run	MIH1	control 1	McCusker D, et al (2007)
View Run	MIH1	control 2	McCusker D, et al (2007)
View Run	MIH1	experimental1 - mih1-1	McCusker D, et al (2007)
View Run	MIH1	experimental2 - mih1-2	McCusker D, et al (2007)
View Run	ASF1	3908: TAP-tagged, includes hir2(delta) in background	Green EM, et al (2005)
View Run	ASF1	3912: TAP-tagged, strain background includes hpc2(delta)	Green EM, et al (2005)
View Run	RLF2	identification data - first search in cascade	Green EM, et al (2005)
View Run	VAM3	Sample: HX11 - both fusion and trans-SNARE complex formation take place.	Hao Xu, et al. (2010)
View Run	VAM3	hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex	Hao Xu, et al. (2010)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: GRP78_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: