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Protein Overview: VMA13

General Information:
Name(s) found: VMA13 / YPR036W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 478 amino acids

    Gene Ontology:
    Cellular Component: vacuolar proton-transporting V-type ATPase, V1 domain [TASLink to PubMed articleLink to PubMed article]
    fungal-type vacuole membrane [TASLink to PubMed article]
    Biological Process: vacuolar acidification [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: proton-transporting ATPase activity, rotational mechanism [TASLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGATKILMDS THFNEIRSII RSRSVAWDAL ARSEELSEID ASTAKALESI LVKKNIGDGL  60
   61 SSSNNAHSGF KVNGKTLIPL IHLLSTSDNE DCKKSVQNLI AELLSSDKYG DDTVKFFQED 120
  121 PKQLEQLFDV SLKGDFQTVL ISGFNVVSLL VQNGLHNVKL VEKLLKNNNL INILQNIEQM 180
  181 DTCYVCIRLL QELAVIPEYR DVIWLHEKKF MPTLFKILQR ATDSQLATRI VATNSNHLGI 240
  241 QLQYHSLLLI WLLTFNPVFA NELVQKYLSD FLDLLKLVKI TIKEKVSRLC ISIILQCCST 300
  301 RVKQHKKVIK QLLLLGNALP TVQSLSERKY SDEELRQDIS NLKEILENEY QELTSFDEYV 360
  361 AELDSKLLCW SPPHVDNGFW SDNIDEFKKD NYKIFRQLIE LLQAKVRNGD VNAKQEKIII 420
  421 QVALNDITHV VELLPESIDV LDKTGGKADI MELLNHSDSR VKYEALKATQ AIIGYTFK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TFP1 VMA10 VMA13 VMA2 VMA4 VMA7 VMA8
    View Details (MIPS) Mewes HW, et al. (2004) CUP5 PPA1 STV1 TFP1 TFP3 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VPH1
    View Details Krogan NJ, et al. (2006) CLG1 CUE1 GTR1 HAM1 HRT1 LAP3 TFP1 VMA10 VMA13 VMA2 VMA7 VMA8 XDJ1 YIG1
    View Details Gavin AC, et al. (2006) VMA13 VMA4 VMA5 VMA7 VMA8
    View Details Gavin AC, et al. (2002) ARB1 ARX1 FUN12 RAV1 TFP1 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VPH1
    View Details Qiu et al. (2008) PMC1 PPA1 TFP1 TFP3 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VMA9 VPH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CTF3 VMA13 1 Unpublished Fields Lab Data
    View Screen SPT21 VMA13 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VMA13 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] PSI-BLAST 10142.0 Regulatory subunit H of the V-type ATPase
    2 View Details [159..239] PSI-BLAST 10142.0 Regulatory subunit H of the V-type ATPase
    3 View Details [240..353] PSI-BLAST 10142.0 Regulatory subunit H of the V-type ATPase
    4 View Details [354..478] PSI-BLAST 10142.0 Regulatory subunit H of the V-type ATPase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrogen ion transmembrane transporter activity
    		•  4.95682565184071 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.85364536397482 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  4.07598420103891 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.97002944013769 bayes_pls_golite062009
  • binding
    		•  2.4389817190572 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.67825644894471 bayes_pls_golite062009
  • protein binding
    		•  1.63705839411934 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  1.42177298480378 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.878543655311892 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.488813981504368 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.409276623620829 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.221901941018475 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle