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Protein Overview: PLC1

General Information:
Name(s) found: PLC1 / YPL268W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 869 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article]
    Biological Process: signal transduction [IMPLink to PubMed article]
    regulation of phosphate metabolic process [IMPLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    vacuole fusion, non-autophagic [IMPLink to PubMed article]
    Molecular Function: phosphoinositide phospholipase C activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTESAIDDQR FNLTKELQRH SCRDQGKITQ KDDALDFISY SSFQSSFNTD QKSANNGSTV  60
   61 RRSIRSIFRR AAELPRVHMG PLTYSHGINE LVNKKLRKDC DLSTLCRVLQ RGIRMIRMTR 120
  121 RRRKFYEFKL INNNGQIIWK DGSKYLELDS VKDIRIGDTA STYQEEVDPK RLRSDSKLWI 180
  181 AIIYKVSNKL KALHVVALNE LDFNTFLSCI CGLVKLRREL MESILLPDNS QFARIHWQIT 240
  241 VSEKEEDEKK DTLSFADVKK LCDKFHIYVS TGQLLEFFQL ADINHNGLLN YFEFEKFIKI 300
  301 LKNRKEVNMI WSKFTKPPHS HLSFENFFQF LITEQHEQVD RQTAWSYFIK YREPTQLTMG 360
  361 QDGFTKFLKE QPYLVEVKEE LYSKPLNHYF IASSHNTYLL GKQIAETPSV EGYIQVLQQG 420
  421 CRCVEIDIWD GENGPVVCHG FLTSAIPLKT VIRVIKKYAF ITSPYPLIIS LEINCNKDNQ 480
  481 KLASLIMREV LAEQLYFVGT RTDKLPSPRE LKHKILLKSK KTSEATRGLS VNEPFPSSFS 540
  541 SSYESANEQE LRMKDDSTNS SSATNSSSMQ RIKRIGLKKH ADIINDVSNI SGIHGIKFRN 600
  601 FSLPESKTIA HCFSLNERKV EYMIKDKHLK LSLDKHNRRY LMRVYPHVLR YKSSNFNPIP 660
  661 FWKAGVQMVA TNWQTNDIGQ QLNLAMFQIL DHQPDGSFKS GYVLKPKKLL PVVTKAKMIP 720
  721 LIYEHFENGS DPVTVKIRIL STQLLPRLND TSPSRNNTNS FVKVEFHTDD EPTMPISIDK 780
  781 GTRISATEAS TKSSQGNGFN PIWDAEVSIT LKDTDLTFIK FMVISEETQI ASVCLKLNYL 840
  841 RMGYRHIPLF NMEGEQYIFC TLFIHTQIL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BTT1 CAF130 EGD1 EGD2 PLC1 YJR011C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] deduced N/A No confident structure predictions are available.
    2 View Details [87..224] PSI-BLAST 20.09691 Phospholipase C delta-1
    3 View Details [225..369] PSI-BLAST 1576.9897 Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
    4 View Details [370..726] PSI-BLAST 1576.9897 Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
    5 View Details [727..869] PSI-BLAST 1576.9897 Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • SH2 domain binding
    		•  3.65625799344693 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.88942227773914 bayes_pls_golite062009
  • insulin receptor binding
    		•  1.93662993549038 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.57653457217606 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.35724984140766 bayes_pls_golite062009
  • DNA binding
    		•  1.35019502849174 bayes_pls_golite062009
  • signal transducer activity
    		•  1.34134699517825 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.34134699517825 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.20299294320291 bayes_pls_golite062009
  • enzyme binding
    		•  1.17212675145623 bayes_pls_golite062009
  • actin binding
    		•  1.15845374680034 bayes_pls_golite062009
  • receptor activity
    		•  1.02045773197699 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.990048359575281 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.893216890968741 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.79883446648737 bayes_pls_golite062009
  • receptor binding
    		•  0.57115269387131 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.51731521446502 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • protein complex binding
    		•  0.22543440052247 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.189879136353541 bayes_pls_golite062009
  • Ran GTPase binding
    		•  0.0789278191015399 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0524559849408587 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0498422520006935 bayes_pls_golite062009
    3
    Term Confidence Notes
  • phosphoric diester hydrolase activity
    		•  4.7164034947025 bayes_pls_golite062009
  • glycerophosphodiester phosphodiesterase activity
    		•  4.27697417361287 bayes_pls_golite062009
  • phospholipase C activity
    		•  4.02608863873812 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphodiesterase activity
    		•  3.53845975637639 bayes_pls_golite062009
  • phosphoinositide phospholipase C activity
    		•  3.53845975637639 bayes_pls_golite062009
  • phospholipase activity
    		•  3.3535603060637 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  3.27299307330343 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.57032504567157 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55650624542181 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37465721152046 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.99763594451773 bayes_pls_golite062009
  • hydrolase activity
    		•  1.77704560318103 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.70224798223084 bayes_pls_golite062009
  • binding
    		•  1.68488937304436 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.48964499825589 bayes_pls_golite062009
  • protein binding
    		•  1.44033231686342 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33654529506691 bayes_pls_golite062009
  • DNA binding
    		•  1.3098416020159 bayes_pls_golite062009
  • lipase activity
    		•  1.30779031242608 bayes_pls_golite062009
  • catalytic activity
    		•  1.22328099675039 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.21223335767967 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.949608579595809 bayes_pls_golite062009
  • signal transducer activity
    		•  0.949608579595809 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • cation channel activity
    		•  0.802117767859521 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.717054504236607 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • motor activity
    		•  0.55768019172905 bayes_pls_golite062009
  • channel activity
    		•  0.386960491413065 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.386960491413065 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.36302486156653 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.362205423422174 bayes_pls_golite062009
  • actin binding
    		•  0.361058618811406 bayes_pls_golite062009
  • ion channel activity
    		•  0.343477643719352 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.278054748078249 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.203504070557827 bayes_pls_golite062009
  • potassium channel activity
    		•  0.200283164564768 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.199755412261029 bayes_pls_golite062009
  • gated channel activity
    		•  0.150185445887481 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.109511951498555 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0585855631213987 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle