YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: PLC1
Organism: Saccharomyces cerevisiae
Length: 869 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PLC1.

Description E-value Query
Range		 Subject
Range
gi|295642 - gi|295642|gb|AAA99927.1| phospholipase C [Saccharomyces cerevisiae]
 0.0 [1..869] [1..869]
gi|20379605 - gi|20379605|gb|AAH27746.1| Plcl2 protein [Mus musculus]
 0.0 [52..868] [95..881]
gi|5689521 - gi|5689521|dbj|BAA83044.1| KIAA1092 protein [Homo sapiens]
 0.0 [52..868] [121..907]
PLCD1_RAT - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Rattus norvegicus GN=Plcd1 PE=1...
gi|206220 - gi|206220|gb|AAA41886.1| phospholipase C-III
 0.0 [84..868] [1..754]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [96..867] [5..754]
gi|149018286 - gi|149018286|gb|EDL76927.1| phospholipase C, delta 1 [Rattus norvegicus]
gi|30352160 - gi|30352160|gb|AAP31521.1| phospholipase C delta [Rattus sp.]
 0.0 [84..868] [1..754]
PLCD4_PIG - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 OS=Sus scrofa GN=PLCD4 PE=2 SV=1
 0.0 [100..868] [16..763]

Back

Predicted Domain #1
Region A:
Residues: [1-86] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTESAIDDQR FNLTKELQRH SCRDQGKITQ KDDALDFISY SSFQSSFNTD QKSANNGSTV  60
   61 RRSIRSIFRR AAELPRVHMG PLTYSH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [87-224] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GINELVNKKL RKDCDLSTLC RVLQRGIRMI RMTRRRRKFY EFKLINNNGQ IIWKDGSKYL  60
   61 ELDSVKDIRI GDTASTYQEE VDPKRLRSDS KLWIAIIYKV SNKLKALHVV ALNELDFNTF 120
  121 LSCICGLVKL RRELMESI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.09691
Match: 1mai__
Description: Phospholipase C delta-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SH2 domain binding 3.65625799344693 bayes_pls_golite062009
binding 3.29080729281876 bayes_pls_golite062009
protein binding 3.17213698546013 bayes_pls_golite062009
phosphoinositide 3-kinase binding 2.88942227773914 bayes_pls_golite062009
insulin receptor binding 1.93662993549038 bayes_pls_golite062009
transcription regulator activity 1.57653457217606 bayes_pls_golite062009
nucleic acid binding 1.35724984140766 bayes_pls_golite062009
DNA binding 1.35019502849174 bayes_pls_golite062009
signal transducer activity 1.34134699517825 bayes_pls_golite062009
molecular transducer activity 1.34134699517825 bayes_pls_golite062009
transporter activity 1.28986800087234 bayes_pls_golite062009
cytoskeletal protein binding 1.20299294320291 bayes_pls_golite062009
enzyme binding 1.17212675145623 bayes_pls_golite062009
actin binding 1.15845374680034 bayes_pls_golite062009
receptor activity 1.02045773197699 bayes_pls_golite062009
transmembrane receptor activity 0.990048359575281 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.893216890968741 bayes_pls_golite062009
substrate-specific transporter activity 0.79883446648737 bayes_pls_golite062009
receptor binding 0.57115269387131 bayes_pls_golite062009
protein domain specific binding 0.51731521446502 bayes_pls_golite062009
GTPase regulator activity 0.355387992614734 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.335498703113274 bayes_pls_golite062009
protein complex binding 0.22543440052247 bayes_pls_golite062009
enzyme regulator activity 0.189879136353541 bayes_pls_golite062009
Ran GTPase binding 0.0789278191015399 bayes_pls_golite062009
pyrophosphatase activity 0.0611639610381174 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0524559849408587 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0498422520006935 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [225-369] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLPDNSQFAR IHWQITVSEK EEDEKKDTLS FADVKKLCDK FHIYVSTGQL LEFFQLADIN  60
   61 HNGLLNYFEF EKFIKILKNR KEVNMIWSKF TKPPHSHLSF ENFFQFLITE QHEQVDRQTA 120
  121 WSYFIKYREP TQLTMGQDGF TKFLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1576.9897
Match: 1djgA_
Description: Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoric diester hydrolase activity 4.7164034947025 bayes_pls_golite062009
glycerophosphodiester phosphodiesterase activity 4.27697417361287 bayes_pls_golite062009
phospholipase C activity 4.02608863873812 bayes_pls_golite062009
inositol or phosphatidylinositol phosphodiesterase activity 3.53845975637639 bayes_pls_golite062009
phosphoinositide phospholipase C activity 3.53845975637639 bayes_pls_golite062009
phospholipase activity 3.3535603060637 bayes_pls_golite062009
phosphoric ester hydrolase activity 3.27299307330343 bayes_pls_golite062009
ion transmembrane transporter activity 2.57032504567157 bayes_pls_golite062009
cation transmembrane transporter activity 2.55650624542181 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37465721152046 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.99763594451773 bayes_pls_golite062009
hydrolase activity 1.77704560318103 bayes_pls_golite062009
transcription regulator activity 1.70224798223084 bayes_pls_golite062009
binding 1.68488937304436 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.48964499825589 bayes_pls_golite062009
protein binding 1.44033231686342 bayes_pls_golite062009
nucleic acid binding 1.33654529506691 bayes_pls_golite062009
DNA binding 1.3098416020159 bayes_pls_golite062009
lipase activity 1.30779031242608 bayes_pls_golite062009
catalytic activity 1.22328099675039 bayes_pls_golite062009
cytoskeletal protein binding 1.21223335767967 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
molecular transducer activity 0.949608579595809 bayes_pls_golite062009
signal transducer activity 0.949608579595809 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
cation channel activity 0.802117767859521 bayes_pls_golite062009
amine transmembrane transporter activity 0.717054504236607 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
motor activity 0.55768019172905 bayes_pls_golite062009
channel activity 0.386960491413065 bayes_pls_golite062009
passive transmembrane transporter activity 0.386960491413065 bayes_pls_golite062009
structural constituent of muscle 0.36302486156653 bayes_pls_golite062009
substrate-specific channel activity 0.362205423422174 bayes_pls_golite062009
actin binding 0.361058618811406 bayes_pls_golite062009
ion channel activity 0.343477643719352 bayes_pls_golite062009
voltage-gated cation channel activity 0.278054748078249 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
voltage-gated channel activity 0.203504070557827 bayes_pls_golite062009
potassium channel activity 0.200283164564768 bayes_pls_golite062009
voltage-gated ion channel activity 0.199755412261029 bayes_pls_golite062009
gated channel activity 0.150185445887481 bayes_pls_golite062009
voltage-gated potassium channel activity 0.109511951498555 bayes_pls_golite062009
structural molecule activity 0.0585855631213987 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [370-726] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQPYLVEVKE ELYSKPLNHY FIASSHNTYL LGKQIAETPS VEGYIQVLQQ GCRCVEIDIW  60
   61 DGENGPVVCH GFLTSAIPLK TVIRVIKKYA FITSPYPLII SLEINCNKDN QKLASLIMRE 120
  121 VLAEQLYFVG TRTDKLPSPR ELKHKILLKS KKTSEATRGL SVNEPFPSSF SSSYESANEQ 180
  181 ELRMKDDSTN SSSATNSSSM QRIKRIGLKK HADIINDVSN ISGIHGIKFR NFSLPESKTI 240
  241 AHCFSLNERK VEYMIKDKHL KLSLDKHNRR YLMRVYPHVL RYKSSNFNPI PFWKAGVQMV 300
  301 ATNWQTNDIG QQLNLAMFQI LDHQPDGSFK SGYVLKPKKL LPVVTKAKMI PLIYEHF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1576.9897
Match: 1djgA_
Description: Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [727-869] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENGSDPVTVK IRILSTQLLP RLNDTSPSRN NTNSFVKVEF HTDDEPTMPI SIDKGTRISA  60
   61 TEASTKSSQG NGFNPIWDAE VSITLKDTDL TFIKFMVISE ETQIASVCLK LNYLRMGYRH 120
  121 IPLFNMEGEQ YIFCTLFIHT QIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1576.9897
Match: 1djgA_
Description: Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle