| Protein: | PLC1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 869 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PLC1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..869] | [1..869] |
|
|
0.0 | [52..868] | [95..881] |
|
|
0.0 | [52..868] | [121..907] |
|
|
0.0 | [84..868] | [1..754] |
|
|
0.0 | [96..867] | [5..754] |
|
|
0.0 | [84..868] | [1..754] |
|
|
0.0 | [100..868] | [16..763] |
|
Region A: Residues: [1-86] |
1 11 21 31 41 51
| | | | | |
1 MTESAIDDQR FNLTKELQRH SCRDQGKITQ KDDALDFISY SSFQSSFNTD QKSANNGSTV 60
61 RRSIRSIFRR AAELPRVHMG PLTYSH
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.541 | a.54.1 | Domain of early E2A DNA-binding protein, ADDBP |
| View | Download | 0.521 | a.54.1 | Domain of early E2A DNA-binding protein, ADDBP |
| View | Download | 0.521 | a.54.1 | Domain of early E2A DNA-binding protein, ADDBP |
| View | Download | 0.472 | a.64.1 | Saposin |
| View | Download | 0.472 | a.64.1 | Saposin |
| View | Download | 0.462 | a.39.1 | EF-hand |
| View | Download | 0.462 | a.39.1 | EF-hand |
| View | Download | 0.430 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.430 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.414 | a.39.1 | EF-hand |
| View | Download | 0.414 | a.4.9 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
| View | Download | 0.401 | a.112.1 | Description not found. |
| View | Download | 0.379 | a.47.2 | t-snare proteins |
| View | Download | 0.369 | d.43.1 | Elongation factor Ts (EF-Ts), dimerisation domain |
| View | Download | 0.364 | a.144.1 | PABC (PABP) domain |
| View | Download | 0.351 | a.39.1 | EF-hand |
| View | Download | 0.308 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.307 | a.12.1 | Kix domain of CBP (creb binding protein) |
| View | Download | 0.292 | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.283 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.271 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.265 | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.261 | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.254 | d.203.1 | DsrC, the gamma subunit of dissimilatory sulfite reductase |
| View | Download | 0.253 | a.3.1 | Cytochrome c |
| View | Download | 0.250 | a.74.1 | Cyclin-like |
| View | Download | 0.250 | a.57.1 | Protein HNS-dependent expression A; HdeA |
| View | Download | 0.248 | a.74.1 | Cyclin-like |
| View | Download | 0.245 | g.53.1 | TAZ domain |
| View | Download | 0.237 | d.134.1 | Sulfite reductase hemoprotein (SiRHP), domains 2 and 4 |
| View | Download | 0.236 | a.8.2 | Plasmid maintenance system epsilon/zeta, antidote epsilon subunit |
| View | Download | 0.233 | a.39.1 | EF-hand |
| View | Download | 0.221 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.220 | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.217 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.216 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.214 | a.121.1 | Tetracyclin repressor-like, C-terminal domain |
| View | Download | 0.214 | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.214 | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.209 | a.74.1 | Cyclin-like |
| View | Download | 0.207 | a.4.5 | "Winged helix" DNA-binding domain |
|
Region A: Residues: [87-224] |
1 11 21 31 41 51
| | | | | |
1 GINELVNKKL RKDCDLSTLC RVLQRGIRMI RMTRRRRKFY EFKLINNNGQ IIWKDGSKYL 60
61 ELDSVKDIRI GDTASTYQEE VDPKRLRSDS KLWIAIIYKV SNKLKALHVV ALNELDFNTF 120
121 LSCICGLVKL RRELMESI
|
| Detection Method: | |
| Confidence: | 20.09691 |
| Match: | 1mai__ |
| Description: | Phospholipase C delta-1 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| SH2 domain binding | 3.65625799344693 | bayes_pls_golite062009 |
| binding | 3.29080729281876 | bayes_pls_golite062009 |
| protein binding | 3.17213698546013 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.88942227773914 | bayes_pls_golite062009 |
| insulin receptor binding | 1.93662993549038 | bayes_pls_golite062009 |
| transcription regulator activity | 1.57653457217606 | bayes_pls_golite062009 |
| nucleic acid binding | 1.35724984140766 | bayes_pls_golite062009 |
| DNA binding | 1.35019502849174 | bayes_pls_golite062009 |
| signal transducer activity | 1.34134699517825 | bayes_pls_golite062009 |
| molecular transducer activity | 1.34134699517825 | bayes_pls_golite062009 |
| transporter activity | 1.28986800087234 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.20299294320291 | bayes_pls_golite062009 |
| enzyme binding | 1.17212675145623 | bayes_pls_golite062009 |
| actin binding | 1.15845374680034 | bayes_pls_golite062009 |
| receptor activity | 1.02045773197699 | bayes_pls_golite062009 |
| transmembrane receptor activity | 0.990048359575281 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.893216890968741 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.79883446648737 | bayes_pls_golite062009 |
| receptor binding | 0.57115269387131 | bayes_pls_golite062009 |
| protein domain specific binding | 0.51731521446502 | bayes_pls_golite062009 |
| GTPase regulator activity | 0.355387992614734 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 0.335498703113274 | bayes_pls_golite062009 |
| protein complex binding | 0.22543440052247 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.189879136353541 | bayes_pls_golite062009 |
| Ran GTPase binding | 0.0789278191015399 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.0611639610381174 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.0524559849408587 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.0498422520006935 | bayes_pls_golite062009 |
|
Region A: Residues: [225-369] |
1 11 21 31 41 51
| | | | | |
1 LLPDNSQFAR IHWQITVSEK EEDEKKDTLS FADVKKLCDK FHIYVSTGQL LEFFQLADIN 60
61 HNGLLNYFEF EKFIKILKNR KEVNMIWSKF TKPPHSHLSF ENFFQFLITE QHEQVDRQTA 120
121 WSYFIKYREP TQLTMGQDGF TKFLK
|
| Detection Method: | |
| Confidence: | 1576.9897 |
| Match: | 1djgA_ |
| Description: | Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| phosphoric diester hydrolase activity | 4.7164034947025 | bayes_pls_golite062009 |
| glycerophosphodiester phosphodiesterase activity | 4.27697417361287 | bayes_pls_golite062009 |
| phospholipase C activity | 4.02608863873812 | bayes_pls_golite062009 |
| inositol or phosphatidylinositol phosphodiesterase activity | 3.53845975637639 | bayes_pls_golite062009 |
| phosphoinositide phospholipase C activity | 3.53845975637639 | bayes_pls_golite062009 |
| phospholipase activity | 3.3535603060637 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 3.27299307330343 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.57032504567157 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.55650624542181 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.37465721152046 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 1.99763594451773 | bayes_pls_golite062009 |
| hydrolase activity | 1.77704560318103 | bayes_pls_golite062009 |
| transcription regulator activity | 1.70224798223084 | bayes_pls_golite062009 |
| binding | 1.68488937304436 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 1.48964499825589 | bayes_pls_golite062009 |
| protein binding | 1.44033231686342 | bayes_pls_golite062009 |
| nucleic acid binding | 1.33654529506691 | bayes_pls_golite062009 |
| DNA binding | 1.3098416020159 | bayes_pls_golite062009 |
| lipase activity | 1.30779031242608 | bayes_pls_golite062009 |
| catalytic activity | 1.22328099675039 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.21223335767967 | bayes_pls_golite062009 |
| transporter activity | 1.15928534291452 | bayes_pls_golite062009 |
| molecular transducer activity | 0.949608579595809 | bayes_pls_golite062009 |
| signal transducer activity | 0.949608579595809 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.945691505472547 | bayes_pls_golite062009 |
| cation channel activity | 0.802117767859521 | bayes_pls_golite062009 |
| amine transmembrane transporter activity | 0.717054504236607 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.693724160233023 | bayes_pls_golite062009 |
| motor activity | 0.55768019172905 | bayes_pls_golite062009 |
| channel activity | 0.386960491413065 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 0.386960491413065 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.36302486156653 | bayes_pls_golite062009 |
| substrate-specific channel activity | 0.362205423422174 | bayes_pls_golite062009 |
| actin binding | 0.361058618811406 | bayes_pls_golite062009 |
| ion channel activity | 0.343477643719352 | bayes_pls_golite062009 |
| voltage-gated cation channel activity | 0.278054748078249 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.246383459363256 | bayes_pls_golite062009 |
| voltage-gated channel activity | 0.203504070557827 | bayes_pls_golite062009 |
| potassium channel activity | 0.200283164564768 | bayes_pls_golite062009 |
| voltage-gated ion channel activity | 0.199755412261029 | bayes_pls_golite062009 |
| gated channel activity | 0.150185445887481 | bayes_pls_golite062009 |
| voltage-gated potassium channel activity | 0.109511951498555 | bayes_pls_golite062009 |
| structural molecule activity | 0.0585855631213987 | bayes_pls_golite062009 |
|
Region A: Residues: [370-726] |
1 11 21 31 41 51
| | | | | |
1 EQPYLVEVKE ELYSKPLNHY FIASSHNTYL LGKQIAETPS VEGYIQVLQQ GCRCVEIDIW 60
61 DGENGPVVCH GFLTSAIPLK TVIRVIKKYA FITSPYPLII SLEINCNKDN QKLASLIMRE 120
121 VLAEQLYFVG TRTDKLPSPR ELKHKILLKS KKTSEATRGL SVNEPFPSSF SSSYESANEQ 180
181 ELRMKDDSTN SSSATNSSSM QRIKRIGLKK HADIINDVSN ISGIHGIKFR NFSLPESKTI 240
241 AHCFSLNERK VEYMIKDKHL KLSLDKHNRR YLMRVYPHVL RYKSSNFNPI PFWKAGVQMV 300
301 ATNWQTNDIG QQLNLAMFQI LDHQPDGSFK SGYVLKPKKL LPVVTKAKMI PLIYEHF
|
| Detection Method: | |
| Confidence: | 1576.9897 |
| Match: | 1djgA_ |
| Description: | Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1) |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [727-869] |
1 11 21 31 41 51
| | | | | |
1 ENGSDPVTVK IRILSTQLLP RLNDTSPSRN NTNSFVKVEF HTDDEPTMPI SIDKGTRISA 60
61 TEASTKSSQG NGFNPIWDAE VSITLKDTDL TFIKFMVISE ETQIASVCLK LNYLRMGYRH 120
121 IPLFNMEGEQ YIFCTLFIHT QIL
|
| Detection Method: | |
| Confidence: | 1576.9897 |
| Match: | 1djgA_ |
| Description: | Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1) |
| Matching Structure (courtesy of the PDB): |
|
