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Protein Overview: GYP5

General Information:
Name(s) found: GYP5 / YPL249C [SGD]
Description(s) found:
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  • gi|74627276|sp|Q12344.1|GYP5_YEAST RecName: Full=GTPase-activating protein GYP5 [NCBI NR]
  • gi|6325007|ref|NP_015075.1| GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; G [NCBI NR]
  • pir||S61015 hypothetical protein YPL249c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1370513|emb|CAA97970.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1061240|emb|CAA91595.1| putative protein [Saccharomyces cerevisiae] [NCBI NR]
  • GTPase-activating protein GYP5 OS=Saccharomyces cerevisiae GN=GYP5 PE=1 SV=1 [Swiss-Prot]
  • GYP5 GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking [mips]
  • GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p [SGD]
  • >Q12344 (Q12344) Chromosome XVI reading frame ORF YPL249C [4932.FASTACCERV.txt]
  • Chr XVI from 79353-76669, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XVI from 76669-79353, reverse complement [yeastorf3.fasta]
  • YPL249C, Chr XVI from 76669-79353, reverse complement [yeast_orfs2]
  • GYP5 SGDID:S0006170, Chr XVI from 79353-76669, reverse complement, Verified ORF [yeastflysequest.fasta]
  • GTPase-activating protein (GAP) for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p; involved in ER to Golgi trafficking; interacts with the yeast amphiphysins, Rvs161p and Rvs167p [Saccharomyces cerevisiae]gi|1 [nrdb_11152004_Chlamydomonas]
  • (Q12344) ORF YPL249c (Hypothetical protein) [cerv4932.FASTAC]
  • GYP5 SGDID:S000006170, Chr XVI from 79353-76669, reverse complement, Verified ORF, "GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also act [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; Gyp5p [Saccharomyces cerevisi [nr-271106-contam.fasta]
  • putative protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • GTPase-activating protein GYP5 [nr-271106-contam.fasta]
  • GYP5 SGDID:S000006170, Chr XVI from 79353-76669, reverse complement, Verified ORF, "GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • GTPase-activating protein GYP5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GYP5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GYP5 SGDID:S000006170, Chr XVI from 79353-76669, Genome Release 64-1-1, reverse complement, Verified ORF, "GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth" [yeast-030211-contam.fasta]
  • GYP5 SGDID:S000006170, Chr XVI from 79353-76669, Genome Release 64-2-1, reverse complement, Verified ORF, "GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YPL249C SGDID:S000006170, Chr XVI from 79353-76669, Genome Release 64-1-1, reverse complement, Verified ORF, "GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 894 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    cellular bud tip [IDALink to PubMed article]
    soluble fraction [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Golgi-associated vesicle [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IGILink to PubMed article][IPILink to PubMed article]
    vesicle-mediated transport [IGILink to PubMed article]
    Molecular Function: Rab GTPase activator activity [IGILink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDKSIEKN TDTIASEVHE GDNHSNNLGS MEEEIKSTPS DQYEEIAIIP TEPLHSDKEL  60
   61 NDKQQSLGHE APTNVSREEP IGISGDEDTQ ITEQNVNEQR QETREPSSEI DLNEPLDVEK 120
  121 DVTTDVQAPN GLNIEKEYDA VKENEKVYAD TKEVVSSPEN REVTGKNSGG EKSSSSKFLD 180
  181 DESGTTTAAN ANDISISSEV TPERSSENDN NQIHITNEVA AGINLNENKE QKAAIEDGPV 240
  241 TAENLSSETA RKVPPIPTQI INEKGDNSSE NEVSAIPTTS SPPLPPRQNV ATSTSPKLPP 300
  301 RGKQREQPPK TKNAVPPPLE EEMKSEKFRK NFEETKRNSY HHVPLTGSKT AQLESTAEIN 360
  361 LIASRYRKTS HHLNKEGEET RESLQEGQSF LKSTFTSFLE NLSEYNEVEN VNEEDREMFK 420
  421 IDWSFWTQVV NDYATVASNE PENLEAHVTN GIPPQIRGII WQLMANSKSR EMEDIYETLL 480
  481 DTECLHEATI RRDLRRTKFV AEDKMESLYK VIKVYSVYDP DVGYTQGMGF IAAPLLINCE 540
  541 NEAESFGLLV GLMKNYGLRE LFLPGMPGLM LMLYQFDRLL EEHSPSLYNR LIREGISSTM 600
  601 YATQWFLTFF AYKFPLEFVL RIFDIVFVEG IEVLLKFAVN LMLKNEETLV KLRFDELLDF 660
  661 LKDELFNYYL MGNQDDASVV QMGLSNGNSF KGNDDGTFSY NVDLFVHDAM TGVYITPLTL 720
  721 RRYRGEYVEI HEKEQKKEDH YESLRIQNHQ LQREAQKLEH DYSILNKENI SAANELIQNR 780
  781 LNMEMLLDEK NDLINTITDI KSQIEEEIRK QNLPNPDASL PKADLREDLE RTISRNNEVM 840
  841 RENGQLEERI TELQAEIDEL ININKEQVST ASLLERDSKA KGRKGWTGFK KVFK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GYL1 GYP5 RVS161 RVS167
    View Details Krogan NJ, et al. (2006) AIM3 BAR1 COA4 GYL1 GYP5 HNT1 KIN2 MEF2 NCP1 PCL10 PRP28 RVS161 RVS167 SAE2 SLK19 TIM21 VPS15
    View Details Ho Y, et al. (2002) DED1 ECM29 GYP5 HOM6 IDH1 ILV5 LYS12 MET18 PHO84 PRE10 RVS167 UBI4 UBP7 URA7 YLR243W
    View Details Qiu et al. (2008) GYP1 GYP5 MSB3 YOS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GYP5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..412] MSA 11.223997 View MSA. No confident structure predictions are available.
    2 View Details [413..637] PSI-BLAST 36.221849 Ypt/Rab-GAP domain of gyp1p
    3 View Details [638..813] PSI-BLAST 22.69897 Heavy meromyosin subfragment
    4 View Details [814..894] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle