YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: MSB3

General Information:
Name(s) found: MSB3 / YNL293W [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 633 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    cellular bud tip [IDALink to PubMed article]
    Biological Process: actin filament organization [TASLink to PubMed article]
    exocytosis [TASLink to PubMed article]
    Molecular Function: Rab GTPase activator activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNDQQRFSL QNRTVLAHPY KRLGGAFTVK SPSVPNFHDK MHSDHSSSDS ALVNGSFRAN  60
   61 DHRSVEPSCL GQASPSEHDG NLSVIDLYGD EVESQRAEGE DDDDNNGDNG NEDLEEVHSD 120
  121 DLDLVPDDDN RQRVELEGAA SATSANSNGI NNTHFDRYGF KKQNNYISEA EYDKWWVEYS 180
  181 QYCVRRKHKW QLLLEKSGLP VTDDSPSRFP SKSERLKRYV RKGIPAEWRG NAWWHFARGQ 240
  241 EKLNKNKGVY SQLLRKMKQI KKQNPNEKQV QDLDIIERDL NRTFPDNIHF QSSLHNKEGP 300
  301 PIIKSLRRVL VAFSLYNPKI GYCQSMNFLA GLLLLFLDEE RAFWMLVIIT SRYLPGVHNI 360
  361 NLEGVNIDQG VLMLCVKEYI PEVWSYIKPS IDHHQKNNKT FSPSNKKVLF NMQKNEFLYR 420
  421 LPPITLCTAS WFMSCFVGVV PIETTLRIWD CLFYEESHFL FKVSLAVLKL SEHDLSKIKP 480
  481 RNNSLNYSWG SNLNQRGGSM GQEDSDMEIF QVIQTFPKTL LNPNEIFEKI IFKRRFNLNR 540
  541 LDQDEIDRCR KFVAAQRLKF KTYGELLGNS TSEADLPIND NTDNKGIHIT SDAVNEALSS 600
  601 EVYGFKKSLA GVHWNNSIKE KVKQMRKKKD KGD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GTT3 MSB3
    View Details Qiu et al. (2008) GYP5 MSB3 SEC4 SMY1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MSB3 SPA2 2 Drees BL, et al. (2001)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSB3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] deduced N/A No confident structure predictions are available.
    2 View Details [132..363]
    [447..458]    		 PSI-BLAST 37.154902 Ypt/Rab-GAP domain of gyp1p
    3 View Details [364..446] PSI-BLAST 37.154902 Ypt/Rab-GAP domain of gyp1p
    4 View Details [459..525] deduced N/A No confident structure predictions are available.
    5 View Details [526..633] MSA 1.096996 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle