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View Structure Prediction Details

Protein: MSB3
Organism: Saccharomyces cerevisiae
Length: 633 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSB3.

Description E-value Query
Range
Subject
Range
gi|190409261 - gi|190409261|gb|EDV12526.1| GTPase activating protein for Ypt6 [Saccharomyces cerevisiae RM11-1a]
MSB3 - GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its acti...
gi|151944254 - gi|151944254|gb|EDN62533.1| GTPase-activating protein [Saccharomyces cerevisiae YJM789]
gi|207341956 - gi|207341956|gb|EDZ69870.1| YNL293Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GYP3_YEAST - GTPase-activating protein GYP3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSB3 PE=1...
0.0 [1..633] [1..633]
TBCD1_BOVIN, TBC... - TBC1 domain family member 1 (Fragment) OS=Bos taurus GN=TBC1D1 PE=2 SV=1, (O97790) TBC1 domain famil...
6.0E-91 [36..628] [5..537]
gi|14041976 - gi|14041976|dbj|BAB55057.1| unnamed protein product [Homo sapiens]
1.0E-90 [24..628] [113..655]
gi|9790251, gi|9... - gi|988221|gb|AAA85223.1| Tbc1, gi|9790251|ref|NP_062610.1| TBC1 domain family, member 1 [Mus musculu...
1.0E-83 [24..615] [565..1094]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNDQQRFSL QNRTVLAHPY KRLGGAFTVK SPSVPNFHDK MHSDHSSSDS ALVNGSFRAN  60
   61 DHRSVEPSCL GQASPSEHDG NLSVIDLYGD EVESQRAEGE DDDDNNGDNG NEDLEEVHSD 120
  121 DLDLVPDDDN R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [132-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRVELEGAAS ATSANSNGIN NTHFDRYGFK KQNNYISEAE YDKWWVEYSQ YCVRRKHKWQ  60
   61 LLLEKSGLPV TDDSPSRFPS KSERLKRYVR KGIPAEWRGN AWWHFARGQE KLNKNKGVYS 120
  121 QLLRKMKQIK KQNPNEKQVQ DLDIIERDLN RTFPDNIHFQ SSLHNKEGPP IIKSLRRVLV 180
  181 AFSLYNPKIG YCQSMNFLAG LLLLFLDEER AFWMLVIITS RYLPGVHNIN LE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [447-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIWDCLFYEE SH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.154902
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [364-446]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVNIDQGVLM LCVKEYIPEV WSYIKPSIDH HQKNNKTFSP SNKKVLFNMQ KNEFLYRLPP  60
   61 ITLCTASWFM SCFVGVVPIE TTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.154902
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [459-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLFKVSLAVL KLSEHDLSKI KPRNNSLNYS WGSNLNQRGG SMGQEDSDME IFQVIQTFPK  60
   61 TLLNPNE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [526-633]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFEKIIFKRR FNLNRLDQDE IDRCRKFVAA QRLKFKTYGE LLGNSTSEAD LPINDNTDNK  60
   61 GIHITSDAVN EALSSEVYGF KKSLAGVHWN NSIKEKVKQM RKKKDKGD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle