Protein Overview: YPL247C

General Information:
Name(s) found:	YPL247C [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest [SGD]
Organism:	Saccharomyces cerevisiae
Length:	523 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPFHNGNKR SSISFGSSQR QPYNKNNYLS GTNGPSSAAQ DQGRGPSPFG MSGNTTNGGN  60
   61 SKRNSGCDLS ATYYASRSPM YSPLDFSPPV FSPNHSQLQQ ARGYAANIPV VSNLMNPSMA 120
  121 SVCEYQSHYP LFGLDWSADD YVCLGSYKED SRNKLQVLHS NDLLSWESVV DADVVYPVSK 180
  181 IQWVPSQLYP RKLATCSDSL RIWSVSPEER QFQEQINLSL CKYNRQHPAN PAAADDMKVI 240
  241 GTFPPITSFD WNTVDTNLII SSSIDTTCIV WDLQSSHYVK TQLIAHDSEV FDVRFLTKST 300
  301 QLFASCGGDG SVRVFDLRSL AHSTIIYEPP SSSVSGATAG TITPSSKGSD ALLRLEPSPY 360
  361 DPNVLATFAA DSNKIIILDM RNPESPILNL QGHGSSVNGI KWHPTKRNVL LSCGDDCQVL 420
  421 YWDLNSSFME INAAGSKSPS IHGTSLEDPD GDTEMTDGGA GSGLNEDPLS LNNNSKQVCK 480
  481 TLETPNMMYA NKTQEINNIA WRPQRGDWFG CVSGKKFQNV RVL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ALT1 HSP60 YPL247C
View Details	Ho Y, et al. (2002)		AHP1 CDC39 DCS1 DCS2 DNM1 GDB1 RAD50 TSA2 UBP15 UBR1 VPS1 YAK1 YLR241W YPL247C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YOR203W	YPL247C	2	Unpublished Fields Lab Data
View Screen	RAD6	YPL247C	1	Unpublished Fields Lab Data
View Screen	YJR023C	YPL247C	1	Hazbun TR, et al. (2003)
View Screen	RLP24	YPL247C	1	Unpublished Fields Lab Data
View Screen	PEX13	YPL247C	1	Unpublished Fields Lab Data
View Screen	YNL311C	YPL247C	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YPL247C	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..122]	PSI-BLAST	21.69897	Groucho/tle1, C-terminal domain
2	View Details	[123..523]	PSI-BLAST	63.512579	beta1-subunit of the signal-transducing G protein heterotrimer

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2