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Protein Overview: WTM2

General Information:
Name(s) found: WTM2 / YOR229W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 467 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: regulation of meiosis [IGILink to PubMed article]
    Molecular Function: transcription corepressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKSKSSQGA SGARRKPAPS LYQHISSFKP QFSTRVDDVL HFSKTLTWRS EIIPDKSKGT  60
   61 LTTSLLYSQG SDIYEIDTTL PLKTFYDDDD DDDNDDDDEE GNGKTKSAAT PNPEYGDAFQ 120
  121 DVEGKPLRPK WIYQGETVAK MQYLESSDDS TAIAMSKNGS LAWFRDEIKV PVHIVQEMMG 180
  181 PATRYSSIHS LTRPGSLAVS DFDVSTNMDT VVKSQSNGYE EDSILKIIDN SDRPGDILRT 240
  241 VHVPGTNVAH SVRFFNNHLF ASCSDDNILR FWDTRTADKP LWTLSEPKNG RLTSFDSSQV 300
  301 TENLFVTGFS TGVIKLWDAR AVQLATTDLT HRQNGEEPIQ NEIAKLFHSG GDSVVDILFS 360
  361 QTSATEFVTV GGTGNVYHWD MEYSFSRNDD DNEDEVRVAA PEELQGQCLK FFHTGGTRRS 420
  421 SNQFGKRNTV ALHPVINDFV GTVDSDSLVT AYKPFLASDF IGRGYDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CCT2 CCT3 CCT6 CIC1 CKA1 CKA2 CKB1 CKB2 DBP10 ENP2 GDE1 HHF1, HHF2 HOT1 KRI1 MRPL1 NOC3 NOP12 NOP2 NOP7 PDI1 POB3 POL2 PUF6 PWP1 RNR2 RRP14 RRP5 RVB1 SFP1 SPT16 SSF1 TCP1 TIF4631 TRL1 UTP22 VMR1 VPS73 WTM1 WTM2 YOR283W YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen APC2 WTM2 2 Unpublished Fields Lab Data
    View Screen TEM1 WTM2 2 Uetz P, et al. (2000)
    View Screen NUP1 WTM2 2 Unpublished Fields Lab Data
    View Screen LOS1 WTM2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data WTM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] deduced N/A No confident structure predictions are available.
    2 View Details [113..467] PSI-BLAST 44.522879 beta1-subunit of the signal-transducing G protein heterotrimer


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle