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Protein Overview: NCS2

General Information:
Name(s) found: NCS2 / YNL119W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 493 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: protein modification process [IMPLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    invasive growth in response to glucose limitation [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MECQRCPASA RNPATVESRK EKFCDECFIK FVSTKQRKQM MKDEYFRNLF KVIYPFEKEG  60
   61 SVSKILLPLS HSDSGSLVML DIVHDLLLEQ TKQHNNRTGF TVDVLTVFTE ENVSVIKERM 120
  121 ESLINEKMSQ LNKISNIFNV HFIDVNEFFN NASEVSTFII DNENFEIFSK SKSVDDSNIL 180
  181 TLKEILGKYC LNNSSRSDLI SIIKTQLIKH FAYENGYNAI MWGHSMTKLS EVIISLVVKG 240
  241 KGSQIATFLD SESFDTLNNK PCKYKNLYPM KDLLSVEIES FLQIRNLAQF LINVEETNVK 300
  301 PNCLIARKSL PSLGQQKLVK NMTINEITNK YFQDIQNDYS NIISTVLRTA DKLTQPKSSM 360
  361 AKPSQCQICQ SKIYTNPSNW LNRITVTSPY PVETTEEKYL FKQWQDSKLG QSHTHYVELL 420
  421 NEIKQGASNS LDVEDGDVKL CYGCLILLNT SIKDKNLVWP KVDTMDITAN ATNKNKELSQ 480
  481 ILDQFEINSD GEE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARC1 ATG14 CAT8 CCC2 HEK2 IRC20 MCA1 MES1 MGA2 NCS2 NHA1 PET127 PHO89 PHO91 YKL050C YLR363W-A
    View Details Gavin AC, et al. (2002) ACT1 ERG13 LYS12 NCS2 RRN3 SAM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NCS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..304] ORFEUS 9.88 Argininosuccinate synthetase, N-terminal domain; Argininosuccinate synthetase, C-terminal domain
    2 View Details [305..493] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity
    		•  3.71561290487771 bayes_pls_golite062009
  • binding
    		•  1.14645408412895 bayes_pls_golite062009
  • DNA binding
    		•  0.992954560970173 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.953721017285257 bayes_pls_golite062009
  • catalytic activity
    		•  0.828867994386867 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.724532065311415 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.225978168389206 bayes_pls_golite062009
  • transferase activity
    		•  0.0776944314618701 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle