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Protein Overview: DSS1

General Information:
Name(s) found: DSS1 / YMR287C [SGD]
Description(s) found:
Found 25 descriptions.
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  • 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 969 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: RNA catabolic process [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: exoribonuclease II activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVRRKVHVL LIARSFHSYT PCFRVTTRGK RQRSKSKQQA KVELDHTREL DNDQATETVV  60
   61 DRSVGPEKDI ESINKDFLQR TKGLEPDIEL KQLPQIKQEF NQRYKDRYVK PSEDWYVNSW 120
  121 RSLTKPKIPL YKLINSDFQL ITKLKAPNPM EFQPVQLMES PLNVGDFVLL KMRPNELAMC 180
  181 VSLPSSTMDP RYTFVTIDGT MCFATKNRVL LRIPHKLPAG IHSLIQPESH HKHLPIGTVK 240
  241 NFSNQTNILP IVARQLITSR YPAQISKLAW KDLPITTKKL QLLHRSLQNY MGPWQIPFFT 300
  301 LVGLVQKLDL NKALDDKNGI NYLTSLVNNY HTVNDIPINS PTFVSTYWAI MQQQESNLWG 360
  361 EIHLNTALLS PISVTIIPLK SQHLYYAQVI EKLEANSYRE VNKFVKLVNE RKYRDISALY 420
  421 PSVIQLLKDF AAGNFHNNGI IVALISKIFR KIERYKDCDI TRDICQDLIN EITPNSIPNP 480
  481 LLLNMDLALP ASSKLVKWQQ KLYDLTNIEE LQWKKSGTDD DRYDFGDLRV FCIDSETAHE 540
  541 IDDGVSVKNY GRDGLYTLYI HIADPTSMFP ESTNVDIEGI STDILNVALK RSFTTYLPDT 600
  601 VVPMLPQSIC HLSDLGKQGQ RTKTISFSVD VKITSKCSGK SIEIMYDSFK IRKGIVSNFP 660
  661 KATYEDVDRI LGTPNSEASP VKKDLESLSM ISKLLREQRI KNSNAVIFGE GFNKGLVMLN 720
  721 ADSEGELTEV TFSDQEETLS TILVSEMMIL ANTLTGRYFA ENKIGGVFRC YKQLPLGEVA 780
  781 QQQYDSMITS TKKGIFPKLK DIVKLSSLLN SSFYTGRPFR HEMIGAKQYL TVTSPLRRFP 840
  841 DLINHLQIHR HLQKKPLCFN QTQIDSLIWP IQSRADILKR ASRNSSTYWT LNYLKKLTKL 900
  901 EPERTFDVMV TSVPQNGFTG CVFPDLSFAR GTLKLHPSSM HYPMIGDIVK NCKISKIDCL 960
  961 EGMLELEKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) DSS1 SUV3
    View Details Krogan NJ, et al. (2006) CSE2 DSS1 GAL11 GPT2 IRC11 MED1 MED11 MED2 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 ROX3 SIN4 SOH1 SRB2 SRB4 SRB5 SRB6 SRB7 SSN3 SSN8 THI72
    View Details Ho Y, et al. (2002) ADH2 APT1 ARO1 CKA1 COP1 DSS1 ECM10 MAM33 MTC5 OYE2 PRE1 PST2 PUP3 SLD2 SOD2 SRP1 STI1 TMA29 TPS1 TRL1 TSA2 YHR033W YKU80

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DSS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..434] deduced N/A No confident structure predictions are available.
    2 View Details [435..852] Pfam 115.236572 RNB-like protein No confident structure predictions are available.
    3 View Details [853..969] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • ribonuclease activity
    		•  3.55580959453362 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.8041095803798 bayes_pls_golite062009
  • DNA binding
    		•  2.12131488750007 bayes_pls_golite062009
  • binding
    		•  1.81248034004657 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.69948951519417 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.66992550564008 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  1.15063310147711 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.10289736160471 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.96886436248958 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.71554089842467 bayes_pls_golite062009
  • structural molecule activity
    		•  0.4798318776164 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.398606646713208 bayes_pls_golite062009
  • hydrolase activity
    		•  0.357828165699872 bayes_pls_golite062009
  • nuclease activity
    		•  0.192509675054684 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle