Protein Overview: IOC2

General Information:
Name(s) found:	IOC2 / YLR095C [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif [SGD]
Organism:	Saccharomyces cerevisiae
Length:	812 amino acids
Gene Ontology:
Cellular Component:	ISW1 complex [IPI]
Biological Process:	chromatin remodeling [IPI]
Molecular Function:	protein binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTKRTRGTR NVGASMPAGA ANADSEDWKE YVSEDIIAQL NKHQLPYSEI LDEKIADLAN  60
   61 HWHFQYVMAW LSNVCESYTT TTFNTDQYGG SSTKCLWKNI KFDEGVFVTD VFSKIDGKDS 120
  121 NYYNDEVDVD EGSQNLYDRI RLQLLHQLAG NKSGQLKDWN VIVNHHLQNS SAYSDLVTDL 180
  181 PFLELEIARQ FDIIYSIIKL IEMKNMIFKN YLANNLHLFT FSEVILDDDN SGGEEMKSLF 240
  241 ALPNVGVLVK KTIHRVKEGS SSQVSQTLNI PIKLQNCTIK ESDPDIPDSV ELIHLEYSHD 300
  301 IDAYLQSITI DYDVITTNWG SMLEYWSENK SSKAIDEFIT NLIPVYAEHR LYSAKLLANR 360
  361 EKERAIAELM TRRKRSSRLV AKEEENKKKD LESEWFEKLD EREQFIRHRN KLVSKEIKKI 420
  421 KDLLWNQLWQ LYDQDYRDEK LTRRNELKDR SGSGTPFFET SLGREEDNPL NEIDIGVLDH 480
  481 GPNFQSSIIP VEPPIPGTVG PLQTGDVPEL PSDFCITKEE LDELANYGIF TPQQEPDNQD 540
  541 SVFQCPGEPE LAPMIITEDT ETDLFNNRPL ICCDHCYRWQ HWECQPPKII ELISSTTKSP 600
  601 QHTLSQRDFG VIIMGNSHGN RRSSRRPQST LEPSTKSSRP TDKRKPLSEC STFICAWCIR 660
  661 DLELELRNIF VPELKIIRAK QRKQQEDRER RKKMKEEKKR LEELAKKREL TESVSPPVFN 720
  721 NAFANMSSST TPSIAAYEKT NPAINPAPNV NAAHPIITYS QQTGSKTVPQ APQAPQTSQA 780
  781 SIQPQQQQQQ QQQQQPLHPK EQNFHFQFPP TN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		IOC2 IOC4 ISW1
View Details	Krogan NJ, et al. (2006)		ESC8 IOC2 IOC3 IOC4 ISW1 YJL068C
View Details	Qiu et al. (2008)		IOC2 IOC3 IOC4 SFH1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	IOC2	MZM1	2	Unpublished Fields Lab Data
View Screen	IOC2	PUP3	2	Unpublished Fields Lab Data
View Screen	IOC2	YLR379W	2	Unpublished Fields Lab Data
View Screen	IOC2	MAM3	2	Unpublished Fields Lab Data
View Screen	IOC2	RPL31A	2	Unpublished Fields Lab Data
View Screen	IOC2	YDR445C	2	Unpublished Fields Lab Data
View Screen	NTA1	IOC2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	IOC2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..285]	deduced	N/A	No confident structure predictions are available.
2	View Details	[286..625]	ORFEUS	7.45	Microbial transglutaminase
3	View Details	[626..812]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
binding	2.43368780168847	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.87245602094334	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.66824971329829	bayes_pls_golite062009
pyrophosphatase activity	1.59870547004658	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.57961205729121	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.57748131423105	bayes_pls_golite062009
helicase activity	1.10209416926557	bayes_pls_golite062009
histone acetyltransferase activity	1.07067040711543	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.07067040711543	bayes_pls_golite062009
DNA-dependent ATPase activity	0.860727914860032	bayes_pls_golite062009
hydrolase activity	0.811278135971081	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.662855930343035	bayes_pls_golite062009
ATP-dependent helicase activity	0.662855930343035	bayes_pls_golite062009
structure-specific DNA binding	0.494751313496664	bayes_pls_golite062009
motor activity	0.465306846212764	bayes_pls_golite062009
protein binding	0.409258528033042	bayes_pls_golite062009
catalytic activity	0.400036839701206	bayes_pls_golite062009
purine nucleotide binding	0.15435325982346	bayes_pls_golite062009
nucleotide binding	0.153440379095025	bayes_pls_golite062009
purine ribonucleotide binding	0.130523976113733	bayes_pls_golite062009
ribonucleotide binding	0.130518519278213	bayes_pls_golite062009
double-stranded DNA binding	0.0935258722285486	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2