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View Structure Prediction Details

Protein: IOC2
Organism: Saccharomyces cerevisiae
Length: 812 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IOC2.

Description E-value Query
Range
Subject
Range
IOC2_YEAST - ISWI one complex protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IOC2 PE=1 SV=...
IOC2 - Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity...
0.0 [1..812] [1..812]

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Predicted Domain #1
Region A:
Residues: [1-285]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTKRTRGTR NVGASMPAGA ANADSEDWKE YVSEDIIAQL NKHQLPYSEI LDEKIADLAN  60
   61 HWHFQYVMAW LSNVCESYTT TTFNTDQYGG SSTKCLWKNI KFDEGVFVTD VFSKIDGKDS 120
  121 NYYNDEVDVD EGSQNLYDRI RLQLLHQLAG NKSGQLKDWN VIVNHHLQNS SAYSDLVTDL 180
  181 PFLELEIARQ FDIIYSIIKL IEMKNMIFKN YLANNLHLFT FSEVILDDDN SGGEEMKSLF 240
  241 ALPNVGVLVK KTIHRVKEGS SSQVSQTLNI PIKLQNCTIK ESDPD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.43368780168847 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.87245602094334 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.66824971329829 bayes_pls_golite062009
pyrophosphatase activity 1.59870547004658 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.57961205729121 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.57748131423105 bayes_pls_golite062009
helicase activity 1.10209416926557 bayes_pls_golite062009
histone acetyltransferase activity 1.07067040711543 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.07067040711543 bayes_pls_golite062009
DNA-dependent ATPase activity 0.860727914860032 bayes_pls_golite062009
hydrolase activity 0.811278135971081 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.662855930343035 bayes_pls_golite062009
ATP-dependent helicase activity 0.662855930343035 bayes_pls_golite062009
structure-specific DNA binding 0.494751313496664 bayes_pls_golite062009
motor activity 0.465306846212764 bayes_pls_golite062009
protein binding 0.409258528033042 bayes_pls_golite062009
catalytic activity 0.400036839701206 bayes_pls_golite062009
purine nucleotide binding 0.15435325982346 bayes_pls_golite062009
nucleotide binding 0.153440379095025 bayes_pls_golite062009
purine ribonucleotide binding 0.130523976113733 bayes_pls_golite062009
ribonucleotide binding 0.130518519278213 bayes_pls_golite062009
double-stranded DNA binding 0.0935258722285486 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [286-625]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPDSVELIHL EYSHDIDAYL QSITIDYDVI TTNWGSMLEY WSENKSSKAI DEFITNLIPV  60
   61 YAEHRLYSAK LLANREKERA IAELMTRRKR SSRLVAKEEE NKKKDLESEW FEKLDEREQF 120
  121 IRHRNKLVSK EIKKIKDLLW NQLWQLYDQD YRDEKLTRRN ELKDRSGSGT PFFETSLGRE 180
  181 EDNPLNEIDI GVLDHGPNFQ SSIIPVEPPI PGTVGPLQTG DVPELPSDFC ITKEELDELA 240
  241 NYGIFTPQQE PDNQDSVFQC PGEPELAPMI ITEDTETDLF NNRPLICCDH CYRWQHWECQ 300
  301 PPKIIELISS TTKSPQHTLS QRDFGVIIMG NSHGNRRSSR 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.45
Match: 1iu4A
Description: Microbial transglutaminase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [626-812]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPQSTLEPST KSSRPTDKRK PLSECSTFIC AWCIRDLELE LRNIFVPELK IIRAKQRKQQ  60
   61 EDRERRKKMK EEKKRLEELA KKRELTESVS PPVFNNAFAN MSSSTTPSIA AYEKTNPAIN 120
  121 PAPNVNAAHP IITYSQQTGS KTVPQAPQAP QTSQASIQPQ QQQQQQQQQQ PLHPKEQNFH 180
  181 FQFPPTN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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