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Protein Overview: ISA1

General Information:
Name(s) found: ISA1 / YLL027W [SGD]
Description(s) found:
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  • gi|6323001|ref|NP_013073.1| Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbo [NCBI NR]
  • gi|2495214|sp|Q07821.1|ISA1_YEAST RecName: Full=Iron sulfur assembly protein 1 [NCBI NR]
  • pir||S64778 hypothetical protein YLL027w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1360208|emb|CAA97476.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Iron sulfur assembly protein 1 OS=Saccharomyces cerevisiae GN=ISA1 PE=1 SV=1 [Swiss-Prot]
  • ISA1 Mitochondrial protein required for normal iron metabolism [mips]
  • Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources [SGD]
  • ISA1, Chr XII from 87402-88154 [yeast_orfs2]
  • Chr XII from 87402-88154 [yeastorf3.fasta]
  • (Q07821) Iron sulfur assembly protein 1 [4932.FASTACCERV.txt]
  • ISA1 SGDID:S0003950, Chr XII from 87402-88154, Verified ORF [yeastflysequest.fasta]
  • Isa1p [Saccharomyces cerevisiae]gi|1360208|emb|CAA97476.1| unnamed protein product [Saccharomyces cerevisiae]gi|2495214|sp|Q07821|ISA1_YEAST Iron sulfur assembly protein 1gi|2131728|pir||S64778 hypothetical protein YLL027w - yeast (Saccharomyces cerevi [nrdb_11152004_Chlamydomonas]
  • ISA1 SGDID:S000003950, Chr XII from 87402-88154, Verified ORF, "Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion re [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; Isa1p [Saccharomy [nr-271106-contam.fasta]
  • Iron sulfur assembly protein 1 [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ISA1 SGDID:S000003950, Chr XII from 87402-88154, Verified ORF, "Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Iron-sulfur assembly protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISA1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ISA1 SGDID:S000003950, Chr XII from 87403-88155, Genome Release 64-1-1, Verified ORF, "Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources" [yeast-030211-contam.fasta]
  • ISA1 SGDID:S000003950, Chr XII from 87403-88155, Genome Release 64-2-1, Verified ORF, "Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins" [20141208_orf_trans.fasta]
  • YLL027W SGDID:S000003950, Chr XII from 87403-88155, Genome Release 64-1-1, Verified ORF, "Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 250 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    Biological Process: iron ion transport [IGILink to PubMed article][ISSLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINTGRSRNS VLLAHRFLST GGFWRGGTNG TMSRTINNVN PFKLKFIPKT VPAAADSVSP  60
   61 DSQRPGKKPF KFIVSNQSKS SKASKSPKWS SYAFPSRETI KSHEEAIKKQ NKAIDEQIAA 120
  121 AVSKNDCSCT EPPKKRKRKL RPRKALITLS PKAIKHLRAL LAQPEPKLIR VSARNRGCSG 180
  181 LTYDLQYITE PGKFDEVVEQ DGVKIVIDSK ALFSIIGSEM DWIDDKLASK FVFKNPNSKG 240
  241 TCGCGESFMV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ISA1 NFU1
    View Details Ho Y, et al. (2002) CBF5 CBP2 CCM1 CDC33 CIC1 DBP7 ENP2 GBP2 HAS1 HMO1 HTB2 IMD1 IMD3 ISA1 KRE33 KRI1 MGM101 MSS116 NOC2 NOP12 NOP6 NPL3 PET127 POL5 PRP43 PUF6 PWP1 RLI1 RRP12 RRP5 TIF4631 TRA1 TSR1 URB1 URB2 UTP10 UTP20 YPP1 YRA1 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ISA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] deduced N/A No confident structure predictions are available.
    2 View Details [111..250] Pfam 50.318759 Iron-sulphur cluster biosynthesis No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle