YRC Public Data Repository - Protein Structure Prediction

Protein:	ISA1
Organism:	Saccharomyces cerevisiae
Length:	250 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISA1.

Description	E-value	Query Range	Subject Range
ISA1 - Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S protei... ISA1_YEAST - Iron-sulfur assembly protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISA1 PE=1...	1.0E-90	[1..250]	[1..250]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-53	[39..250]	[39..261]
ISCA1_MOUSE - Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Mus musculus GN=Isca1 PE=2 SV=1 gi\|55715726 - gb\|AAH86084.1\| Unknown (protein for MGC:98458) [Xenopus laevis]	3.0E-44	[136..250]	[14..129]
gi\|158274246, gi... - gi\|16798390\|gb\|AAL29443.1\|AF428268_1 iron-sulfur cluster assembly protein IscA [Chlamydomonas reinha...	6.0E-44	[123..248]	[2..127]
ISCA1 - iron-sulfur cluster assembly 1 homolog (S. cerevisiae) gi\|117646260 - gi\|117646260\|emb\|CAL38597.1\| hypothetical protein [synthetic construct] gi\|114701127 - gi\|114701127\|ref\|XP_001136504.1\| PREDICTED: similar to GK004 isoform 2 [Pan troglodytes] HGNC:28660\|MIM:6... - cluster assembly 1 homolog (S. cerevisiae) gi\|109112034 - gi\|109112034\|ref\|XP_001082365.1\| PREDICTED: similar to HESB like domain containing 2 [Macaca mulatta... ISCA1_BOVIN - Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Bos taurus GN=ISCA1 PE=2 SV=1 ISCA1_MACFA - Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Macaca fascicularis GN=ISCA1 PE=2 SV=1	9.0E-44	[136..250]	[14..129]
gi\|11279039 - pir\|\|H81089 HesB/YadR/YfhF family protein NMB1381 [imported] - Neisseria meningitidis (strain MC58 s... gi\|15677244, gi\|... - gi\|7226622\|gb\|AAF41749.1\| HesB/YadR/YfhF family protein [Neisseria meningitidis MC58], gi\|15677244\|r...	5.0E-42	[129..250]	[2..126]
l(1)G0136-PA - The gene lethal (1) G0136 is referred to in FlyBase by the symbol Dmel\l(1)G0136 (CG8198, FBgn002666... gi\|195478946, gi... - gi\|195478946\|ref\|XP_002100707.1\| GE17212 [Drosophila yakuba], gi\|194188231\|gb\|EDX01815.1\| GE17212 [D... gi\|220958998, gi... - gi\|220960216\|gb\|ACL92644.1\| l(1)G0136-PA [synthetic construct], gi\|220958998\|gb\|ACL92042.1\| l(1)G013... gi\|194894350, gi... - gi\|194894350\|ref\|XP_001978048.1\| GG17904 [Drosophila erecta], gi\|190649697\|gb\|EDV46975.1\| GG17904 [D... gi\|194129462, gi... - gi\|195355387\|ref\|XP_002044173.1\| GM22570 [Drosophila sechellia], gi\|194129462\|gb\|EDW51505.1\| GM22570...	4.0E-41	[137..249]	[16..129]
gi\|17428034 - gi\|17428034\|emb\|CAD14723.1\| conserved hypothetical protein [Ralstonia solanacearum GMI1000] gi\|17545740 - gi\|17545740\|ref\|NP_519142.1\| hypothetical protein RSc1021 [Ralstonia solanacearum GMI1000]	1.0E-39	[146..250]	[1..106]
gi\|144978684, gi... - gi\|145629181\|ref\|ZP_01784980.1\| hypothetical protein CGSHi22121_10275 [Haemophilus influenzae 22.1-2... gi\|42631947 - gi\|42631947\|ref\|ZP_00157485.1\| COG0316: Uncharacterized conserved protein [Haemophilus influenzae R2... ERPA_HAEIN - Iron-sulfur cluster insertion protein ErpA OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 ... YADR_HAEIN, ERPA... - (P45344) Protein HI1723, Uncharacterized protein HI1723 - Haemophilus influenzae, Iron-sulfur cluste... gi\|145639124, gi... - gi\|145639124\|ref\|ZP_01794731.1\| hypothetical protein CGSHiII_03779 [Haemophilus influenzae PittII], ...	1.0E-39	[147..250]	[9..114]
Y1857_AQUAE, YI5... - (O67709) Protein AQ_1857, Protein aq_1857 OS=Aquifex aeolicus GN=aq_1857 PE=1 SV=1 Y1857_AQUAE - Protein aq_1857 OS=Aquifex aeolicus (strain VF5) GN=aq_1857 PE=1 SV=1	2.0E-39	[139..249]	[2..114]

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Predicted Domain #1

Region A:
Residues: [1-110]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINTGRSRNS VLLAHRFLST GGFWRGGTNG TMSRTINNVN PFKLKFIPKT VPAAADSVSP  60
   61 DSQRPGKKPF KFIVSNQSKS SKASKSPKWS SYAFPSRETI KSHEEAIKKQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [111-250]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKAIDEQIAA AVSKNDCSCT EPPKKRKRKL RPRKALITLS PKAIKHLRAL LAQPEPKLIR  60
   61 VSARNRGCSG LTYDLQYITE PGKFDEVVEQ DGVKIVIDSK ALFSIIGSEM DWIDDKLASK 120
  121 FVFKNPNSKG TCGCGESFMV

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	50.318759
Match:	PF01521
Description:	Iron-sulphur cluster biosynthesis

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits